1. A conscious rethink: Why is brain tissue commonly preserved in the archaeological record? Commentary on: Petrone P, Pucci P, Niola M, et al. Heat-induced brain vitrification from the Vesuvius eruption in C.E. 79. N Engl J Med 2020;382:383-4. DOI: 10.1056/NEJMc1909867
- Author
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Tim Thompson, Stephen Buckley, Jane Thomas-Oates, Axel Petzold, Alexandra L. Morton-Hayward, Sonia O'Connor, Abigail Ramsøe, Matthew J. Collins, Neurology, APH - Methodology, APH - Mental Health, Amsterdam Neuroscience - Neuroinfection & -inflammation, Ophthalmology, Morton-Hayward, AL [0000-0002-0711-8381], Thompson, T [0000-0003-3265-524X], Thomas-Oates, JE [0000-0001-8105-9423], Buckley, S [0000-0002-1026-6975], Petzold, A [0000-0002-0344-9749], Ramsøe, A [0000-0001-5132-007X], O’Connor, S [0000-0003-4317-8645], Collins, MJ [0000-0003-4226-5501], and Apollo - University of Cambridge Repository
- Subjects
Archeology ,Heat induced ,Future studies ,business.industry ,Archaeological record ,Brain tissue ,030204 cardiovascular system & hematology ,soft tissue preservation ,Archaeology ,vitrification ,proteins ,palaeoproteomics ,lipids ,03 medical and health sciences ,0302 clinical medicine ,lcsh:Archaeology ,Medicine ,Vitrification ,lcsh:CC1-960 ,030212 general & internal medicine ,business - Abstract
Brain tissue is ubiquitous in the archaeological record. Multiple, independent studies report the finding of black, resinous or shiny brain tissue, and Petrone et al. [2020 “Heat-induced Brain Vitrification from the Vesuvius Eruption in C.E. 79.” N Engl J Med. 382: 383–384; doi:10.1056/NEJMc1909867] raise the intriguing prospect of a role for vitrification in the preservation of ancient biomolecules. However, Petrone et al. (2020) have not made their raw data available, and no detailed laboratory or analytical methodology is offered. Issues of contamination and misinterpretation hampered a decade of research in biomolecular archaeology, such that addressing these sources of bias and facilitating validation of specious findings has become both routine and of paramount importance in the discipline. We argue that the evidence they present does not support their conclusion of heat-induced vitrification of human brain tissue, and that future studies should share palaeoproteomic data in an open access repository to facilitate comparative analysis of the recovery of ancient proteins and patterns of their degradation.
- Published
- 2022
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