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Inflammatory myofibroblastic tumor (IMT) is a rare tumor with an indolent course. It is less often reported as a second tumor that occurs after treatment of malignant tumors in pediatric patients. Here, we report a case of IMT following Wilms tumor (WT), and conduct a literature review concerning IMTs and WT to evaluate the diagnostic possibility of IMT as a second tumor. The coexistence of the 2 tumors may cause confusion as to whether they share genetic links or that IMTs may appear as late effects of the treatment of WT.

Background To analyze the relationship between tumor viability in specimens retrieved at second-look procedures (SLPs) and clinical outcomes in patients with bladder/prostate rhabdomyosarcoma (BP RMS). Methods We retrospectively analyzed patients` characteristics, times between diagnoses and SLPs, types of SLPs, the pathological findings, and clinical outcomes between January 2003 and May 2014. Results A total of 29 patients underwent at least one SLP before completing chemotherapy, including 24 boys and 5 girls. The mean age was 36 months. No patients with clinical/radiographic complete responses (CRs) had viable tumor cells and 7/18 patients (38.9%) without CR had no viable tumor cells. Seven patients experienced tumor relapse, progression, and metastasis, and three of these survived. Five-year event-free survival (EFS) rates were 88.5% in 18 patients without viable tumor at SLPs and 54.5% in 11 patients with viable tumor (Cox proportional hazards adjusted P=0.045). The respective five-year overall survival (OS) rates were 94.1% and 72.7% (Cox proportional hazards adjusted P=0.175). Conclusions EFS was increased in patients with BP RMS having no viable tumor cells; however, OS was comparable in patients with and without viable tumor cells. Patients who achieved CR during the treatment generally had no viable tumor cells.

Purpose To present the clinicopathological characteristics and outcome of children with bladder and ureteral inflammatory myofibroblastic tumors (IMTs) in our center. Methods We reviewed the medical records of patients with bladder and ureteral IMTs from 2010 to 2018. We recorded patients’ demographic data, presentation, hemoglobin level, presence of hydronephrosis, tumor size, treatment, and outcomes. Results Eight patients with bladder IMTs and 3 with ureteral IMTs were treated at our center during this period. The mean age was 7.1 years. Four patients presented with anemia at diagnosis with the mean hemoglobin level 84.5 g/L. Among patients with bladder IMTs, 5 were male and 3 were female. The most common symptom was lower urinary symptoms in 6 patients, followed by hematuria in 4 patients. 2 patients had complications of hydronephrosis and hydroureter. Among patients with ureteral IMTs, 2 were male and one was female. The most common symptom was abdominal pain, and 3 patients presented with upper urinary tract dilation. All patients underwent surgery. A total of 81.8% were positive for anaplastic lymphoma kinase. Cytokeratin (CK) expression was present in all patients with bladder IMTs, while it was negative in 2 patients with ureteral IMTs. During mean follow-up of 43.4 months, all patients survived event-free. Conclusion The presence of hydronephrosis and hydroureter is rare in patients with bladder IMTs. Anemia caused by hematuria should be raised the index of suspicion for IMTs. Children with bladder and ureteral IMTs had excellent prognosis. The expression pattern of CK varied between bladder and ureteral IMTs.

Objectives The present work evaluated preventive effect of curcumin on cisplatin-induced bladder cystopathy. Methods Fifteen female rats were divided into (i) Control group administered with physiological saline solution for 5 days; (ii) Cis-P group injected with cisplatin (6 mg/kg); and (iii) Cis-Cur group given cisplatin (6 mg/kg) with curcumin for 5 consecutive days. The function of bladder was measured by means of urodynamic analysis. Furthermore, hematoxylin-eosin staining and Masson trichrome staining were performed for morphological analysis. The cell apoptosis was evaluated through terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) assay and flow cytometry. The expression of nerve growth factor (NGF), NF-E2-related factor 2, and hemeoxygenase-1 (HO-1) levels were measured through Western blotting. Results Urodynamic assay and histopathological manifestations revealed that curcumin ameliorated the bladder dysfunction induced by cisplatin. The level of cisplatin-induced apoptosis in the bladder decreased following curcumin treatment. Also, the increased protein expression of NGF indicated that the curcumin could offer neuroprotection for bladder against cisplatin. Curcumin also activated NRF2, and elevated the expression of HO-1, but curcumin could not rescue cisplatin-induced apoptosis in the cell lines with knockdown of NRF2. Conclusions Taken together, the results of this paper showed that curcumin could ameliorate cisplatin-induced cystopathy and inhibit the apoptosis of bladder cell in cisplatin-treated rats. This may be attributed to curcumin's broad biological functions, particularly antioxidant effect, and to its ability to activate the NRF2 protein.

Taiji-1 satellite was successfully launched on 31 August 2019, and it has been operating normally in orbit until now. A series of in-orbit experiments were carried out with the inertial sensor, which included the micro-thrust test, drag-free control test and laser interferometer test. Comprehensive performance simulations and tests of the inertial sensor were also carried out prior to the launch of Taiji-1, including the calibration and drop-tower tests. These tests were one of the preconditions for the success of these experiments. The calibration experiments were conducted in a cave-lab using the gravity-inclination method and the scale factors of the inertial sensor along Y- and Z-axis were measured. In addition, 20 drop-tower tests were carried out in the National Microgravity Laboratory of China (NMLC) drop tower and the control stability of all the axes was tested and optimized. A simulation model was used before each test, and the results showed that an accurate simulation prior to each experiment had an important role in ensuring the efficiency and accuracy of the experiment. The circuit-gain switch was realized for the first time during the drop-tower tests. The test results indicated that the microgravity level of the NMLC drop tower could reach about 13 [Formula: see text]g0 along the horizontal axes, offering an important reference for researchers planning to conduct microgravity experiments in the NMLC drop tower.

It has been previously suggested that cytokeratins (CKs) are important diagnostic and prognostic biomarkers for urothelial lesions. Hence it is imperative to understand the expression pattern of cytokeratins during formation of papillary bladder cancer, which was the objective of the current study. Expression pattern of CK14 and CK18 were examined using immunohistochemical staining in a mice model of papillary bladder cancer. Twenty female mice were divided into two groups—group 1 (NT) and group 2, which received N-butyl- N-(4-hydroxybutyl) nitrosamine (BBN) for 20 weeks plus one week without treatment. Following histological classification of bladder lesions, CK14 and CK18 immunostaining was assessed according to its distribution and intensity. In NT animals, both basal cells and umbrella cells showed sporadic positive staining for CK14 and CK18, respectively. In BBN group, hyperplastic lesions showed significantly more CK14 and significantly less CK18 staining ( P Impact statement Studies have shown that expression of cytokeratins (CKs) or their altered distribution affects the bladder cancer pathogenesis and disease outcome, while the underlying mechanisms are not clear. The present study aims to explore the expression pattern of CK14 and CK18 during formation of papillary bladder cancer. The results showed that hyperplastic lesions showed significantly more CK14 and significantly less CK18 staining and invasive carcinomas showed increased CK14 immunostaining in all epithelial layers in N-butyl- N-(4-hydroxybutyl)nitrosamine (BBN)-induced mouse model. The results indicate that altered CK14 (high) and CK18 (low) expression is perhaps an early event in bladder cancer tumorigenesis and is characteristic of both urothelial superficial pre-neoplastic and neoplastic lesions, which may provide the early diagnosis index.

Background Concerns regarding the use of selected bone marrow stem cells (BMSCs) in the field of cardiac repair after acute ischemic events have been raised. The current meta-analysis aimed to assess the efficacy and safety of selected BMSC transplantation in patients with acute myocardial infarction (AMI) based on published randomized controlled trials (RCTs). Methods A systematic literature search of PubMed, Ovid LWW, BIOSIS Previews, and the Cochrane library from 1990 to 2014 was conducted. Results from RCTs involving subjects with AMI receiving selected BMSC therapy and followed up for at least 6months were pooled. Results Eight trials with a total of 262 participants were included. Data were analyzed using a random effects model. Overall, selected BMSC therapy improved left ventricular ejection fraction (LVEF) by 3.17% (95% confidence interval [CI] 0.57–5.76, P=0.02), compared with the controls. There were trends toward reduced left ventricular end-systolic volume (LVESV) and fewer major adverse cardiac events (MACEs). Subgroup analysis revealed a significant difference in LVEF in favor of selected BMSC therapy with bone marrow mesenchymal stem cells (BMMSCs) as the cell type. Conclusions Transplantation of selected BMSCs for patients with AMI is safe and induces a significant increase in LVEF with a limited impact on left ventricular remodeling.

For the engine maintenance enterprises, the test of aeroengine test can detect the performance of the product more accurately, but the engine testing work is a weak link. Conventional piston aircraft engine test system is the simulation instrument, according to the observed by human eyes, manual way to complete data collection work, this test system is inefficient. The engine bench test automatic measurement and control and monitoring system based on computer control is the inevitable trend of its development. Data acquisition module transmits the real-time data from the engine sensor installed on the different parts to the PC through CAN bus and display on the PC. The engine test bed control system and data acquisition system simplifies the system structure and obviously improves the test level and efficiency of the system.

A spectrum-folded Hadamard Transform spectrometer in near-infrared band has been proposed and designed to widen the spectral range of measurement as well as to improve the spectral resolution. The full spectral region of 800 nm to 2000 nm is divided into two bands of 800 nm to 1400 nm and 1400 nm to 2000 nm and dispersed by two sub-gratings. The optimal incident angles of 12.6 degrees and 6.7 degrees respectively for two sub-gratings are chosen to achieve the highest diffraction efficiency. The results show that the spectral resolution of the system is better than 6 nm. The stray light from sub-gratings and DMD are suppressed to minimize the effect on the measurement results. (C) 2014 Elsevier B.V. All rights reserved.

According to the dynamic compaction project of Beijing Garden EXPO Park, an experiment is designed to monitor the deformation and vibration range impact by dynamic compaction.The vibration velocity, vibration acceleration, settlement and deep horizontal displacement of the foundationare obtained through the continuous real-time monitoring during the experiment.In this paper, the expression of vibration velocity and acceleration decreased by distance is established according to the experimental data, besides, the relation ofsingle settlement and total settlementof tamp pit changed with hit numbers is also achieved.The study shows that,under the 3000kJ compact energy,the settlement range is about a circle with radius12.7m; the deep horizontal displacement changes only in range of radius 7.7m; the safety distance of vibration is 47.7m, and to fulfilling the requirement of consolidation 7 hits is appropriate. The study provides a reference to dynamic compacting processof this project.

Designed a monitoring system for Electric Vehicle battery controller to calibrate the parameters and detect the faults. The Monitoring System consists of host monitoring software and USB (Universal Serial Bus) 2.0 interface module. Programmed by C#, host monitoring software provides a UI (User Interface) to display the status of the battery controller and send the command to it. USB 2.0 interface module uses the chip Cy7C68013A to transfer data between the host monitoring software and battery controller. Tests showed that the monitoring system supported hot Plug and Play, high speed mode and easy portability. This system greatly reduces the user operating difficult, and improves the battery efficiency.

Based on the rigid-flexible coupling virtual prototyping technology, the entities model of wheel loaders structural system was established by using Pro/E, then it was imported into the ADAMS environment and constraints were added to create a rigid model, and the corresponding rigid body was replaced by the model neutral file generated by ANSYS, thereby the rigid-flexible coupling virtual prototype was established. The speed and acceleration curve of bucket in a work cycle, the dynamic stress of link and the rear frame was achieved, and the dynamic characteristics of the bucket was analyzed. This paper can provide a reference for similar models of rigid-flexible coupling dynamics simulation.

To South-to-north water transfer project as the background, and based on the Peck formula, this paper educes the formula of settlement and internal force which caused by disturbance of the tunnel of the buried pipeline. Considering the different depths of the buried pipelines, the different diameter of the tunnel, the spacing interval between different tunnels and the depth of different tunnels and so on, this paper analyzes the effect of the twin-parallel-tunnels passing through construction on buried oil & gas pipeline. The research shows that the tunnel diameter has no effect on the width of surface subsider and the deflection of buried oil & gas pipelines, but it has great influence on pipeline internal forces. The spacing interval of tunnel has almost no influence on pipe deflection but has effect on the maximum internal force. Different depths of the tunnel contributes much to the rule of pipeline settlement and the distribution of internal forces, and it has greater influence on the internal force than on the pipe deflection . The relationship between the effect and the depth of the tunnels is non-linear. With the tunnel depth increasing, the hazardous conditions of the pipelines show significant improvement.

Based on the previous experiments and theoretical analyses, finite element analyses (FEA) and parametric study on seismic behavior of Cover Plate Strengthen-Beam Flange Weaken Beam-to-Column (CPSBFW) connection are executed by using ABAQUS. Suggestions on design conceptions and details of the cover plate strengthen-beam flange weaken beam-to-column connection are presented in this paper, and that provide valuable reference for design of beam-to-column connections in steel structures.

The stability study is one of the hot spots of the urban transport design for the subway through the existing structure. The maximum settlement of the structure is regarded as the index of underneath the subway construction and design in this article, the mechanical parameters for pipe shed reinforcement layer on a subway station passing through the existing structure is back analyzed by utilizing the orthogonal experiment design methods, and the mechanical integration properties parameters which is close to engineering practice including elastic modulus, Poisson ratio, cohesion and internal friction angle for the material in the pipe shed reinforcement area are got. The steel pipe reasonable spacing range of advanced pipe shed support is got mainly on the basis of flexural rigidity. The stability analysis and evaluation for the construction of the new subway through the existing subway structure are carried out by utilizing the obtained optimum parameters.

Construction process simulation analysis for high-rise steel frame concrete core-wall structure is conducted by using ABAQUS .The influences of construction process on axial force of bottom column and vertical differential deformation are discussed , some useful conclusions are obtained and reasonable references are provided for the structure design and construction .

A novel Hadamard transform spectrometer collimated by a freeform lens has been designed, which doubles the working spectral range while the spectral resolution is maintained. The freeform lens is designed to redistribute the broadband spectra of the source from 800 nm to 2400 nm into two collimated beams with different wavelengths and different tilting angles, to achieve the folding of spectra on the digital micro-mirror devices (DMD). It is constructed by solving two partial differential equations. The grating diffraction efficiency of the two split beams are more uniform and higher compared with the traditional method. The simulation results show that the bandwidth of the spectrometer is doubled and the spectral resolution is better than 10 nm. The optical system becomes more compact, and the energy efficiency is improved by 11.98% by folding the spectra with one freeform lens and one grating.

Based on different surrounding rock classifications, the numerical simulation of visco-elasto-plastic surrounding rock was studied for three roadway tunnels with small spacing, especially analyzing the visco-elasto-plastic effect in the process of rock mass excavation by the step. By the numerical imitation and comparing analysis, the damage characteristic and the deformation law of surrounding rock were given under the same construction method for different surrounding rock classifications of three driveway tunnels, and the deformation law of interval wall and the relationship between the surrounding rock classification and the interval were obtained under the particular construction method for tunnels with small spacing. The minimum interval was selected for engineering design reference under the same excavation way, and a set of reasonable value ranges was given. The reference data and the theoretical basis were provided for the development and construction design of roadway tunnels with small spacing.

Application of π-multilayer technology is extended to high extinction coefficient materials, which is introduced into metal-dielectric filter design. Metal materials often have high extinction coefficients in far ultraviolet (FUV) region, so optical thickness of metal materials should be smaller than that of the dielectric material. A broadband FUV filter of 9-layer non-periodic Al/MgF2 multilayer was successfully designed and fabricated and it shows high reflectance in 140–180 nm, suppressed reflectance in 120–137 nm and 181–220 nm.

Applications of Mo/Si multilayer mirrors for the moon-based extreme ultraviolet Camera (EUVC) require not only the minimal residual stress, but also little stress changes in the temperature environment on lunar surface. Hence, we deposit the 16.5 nm period Mo/Si multilayer mirror with a low as-deposited residual stress of-36 Mpa (compressive). The in-situ and real time stress tests are measured in the temperature cycling range from 20 C to 130 C. The results indicate that the stress gradually increases to the maximum of-100 MPa when heating up to 105 C, then it gradually relaxes to 10 Mpa after thermal cycling to 130 C. Such stress change has little influence on the performance of the Mo/Si multilayer mirror. 2014 SPIE.

the worldwide application of IT, typically represented by computer technology, has laid a solid foundation for the hotel Informatization. At present, most of guest serving and receiving business are processed with IT. But still, there is some inadequacy in the controlling system of distribution channels. To solve these problems and to meet needs, more and more newly invented technologies are applied in IT-based hotel management. Like internet of Things technology, distribution technology, cloud computing. Presently, in Chinas market numbers of entrepreneurs are committed to try to take advantage of these new technologies in hotel operation and management. But the most important things are to fully consider the applicability of the information technology and to realize of unified and unimpeded information flow. Following are the steps to be adopted: Information standardization and reservation procedure standardization, Hotel networking, Hotel service creation, Application of socialized media, Prompt service and customized service.

To automatic test the function and performance of an airborne radar, changeable test adapter is adopted to implement the hardware and software design of the automatic test set of the antenna, transceiver and indicator of the radar based on AT89C52. Problems such as t the different types of interfaces, the various kinds of signals and the test of microwave signal are solved successfully and the objectives of resource sharing and automatic test are realized. The test software is designed by modular structure, and with the help of automatic test set hardware, the required test items of the radar system are experimented and the test process control succeeded. Experiment results show that the automatic test set performs steadily and the results meet the requirements of the airborne radar. The set has the advantages of intelligent, manageable and reducing artificial errors. It provides effective guarantees for radars maintenance, fault diagnosis and fault detection, and has a wide application prospect with low cost.

Most password-authenticated key agreement protocols have focused on authenticated key agreement using shared password between a client and a server. With the emergence of a variety of communication environments such as EPC global network, it is necessary to construct a secure channel between clients. Cross-realm client-to-client password-authenticated key agreement (C2C-PAKA) protocol can provide secure authenticated key agreement for two clients of different realms, who only share their passwords with their own servers. In 2009, Liu proposed a verifier-based key exchange protocol in cross-realm setting. However, the protocol is susceptible to server compromise attack. In this paper, we propose an improved verifier-based cross-realm C2C-PAKA protocol based on EC2C-PAKA protocol. While holding all the claiming security characteristics of the original protocol, the new protocol can resist server compromise attack. We have proved the improved protocol is secure under the Diffie-Hellman assumption and discrete logarithm assumption. In addition, the improved protocol only requires 12 modular exponentiation, which is more efficient and thus of greater practicality than previous solutions.

Based on the engineering construction of new subway across existing metro tunnel, the settlement law of the existing metro concrete structures was researched due to construction perturbation under existing metro tunnel. According to the in-situ monitoring information and engineering geological conditions, the foundation model, structure analysis model and settlement curve model which are suitable for the main structure deformation have been respectively established, and the internal force and the stress law of the main structure were obtained through deformation analysis. The structure limit analysis model the maximum settlement, the maximum settlement difference value and the distributive characteristics of deformation and the internal force were determined in the whole construction period. The safety stability of the main structure and the normal operation of existing metro tunnel were evaluated, and the warning value was provided for the in-situ construction control.

The construction of highway tunnel entrance is always difficult, the good and bad entrance ways of tunnel directly influence the construction schedule and exterior environment quality. Based on Keshutu tunnel entrance engineering, the half-open and half-hidden entrance way of half hollow-out form was simulated by considering topography, geology and environmental conditions in the paper. The results have shown that the half-open and half-hidden entrance way of half hollow-out form is security and effective for the Keshutu tunnel, and the retaining wall structure has obvious effect on the support of half-open and half-hidden entrance, which can not only protect natural environment but also make the construction security and stabile. Under unsymmetrical pressure loads, the deformation values are bigger at the tunnel vault, the floor midpoint and the central part of the arch wall than at other points. But the deformation values are in security and stabile states. The rock bolts at the vault and the side wall are in tensile state, and the maximum axial tensile stress is 162.9kPa. The tensile stress appears in the vault of the lining structure, and the maximum value is 96.89kPa. The maximum tensile stress values of the anchor and the lining structure during the construction are both far below their tensile strength. The conclusions obtained have certain reference value for similar projects.

In order to study the safety stability of shallow tunnels under unsymmetrical pressure and traversing existing roads, a 3D numerical model of considering real surface elevation changes was established for a different construction scheme in a different range according to the Changshao neighborhood tunnel engineering on the Xi-kang Expressway. The construction process of traversing the S102 road was simulated in the entrances’ range. The deformation law, the stress distribution, the deformation characteristics of middle wall and lining supporting structure, and the settlement law of existing highway surface were obtained for range of the shallow covering excavation and shallow hiding excavation. The safety evaluations on the engineering construction of traversing the existing highway were made. The analyzed results had positive effects on the successful construction of the Changshao neighborhood tunnel.

A Mott-Davis-Paracrystalline model was proposed to interpret thickness effect of the band gap for amorphous germanium (a-Ge). We believe that a-Ge has a semiconductor-alloy-like structure, it may contain medium-range order (MRO) and continuous random network (CRN) simultaneously and there is a dependence of MRO/CRN ratio on film thickness and preparation methods/parameters. For MRO is dominant, thickness effect can be described by one-dimensional quantum confinement (ODQC) effect of nanocrystals and strain-induced shrinkage of the band gap; For CRN is dominant, thickness dependence can be interpreted by changes in the quality of a CRN and ODQC effect of nanoamorphous phase.