1. Hypoglycemic effects of Ganoderma applanatum and Collybia confluens exo-polymers in streptozotocin-induced diabetic rats.
- Author
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Yang BK, Jung YS, and Song CH
- Subjects
- Animals, Biopolymers analysis, Biopolymers pharmacology, Diabetes Mellitus, Experimental pathology, Eating drug effects, Hypoglycemic Agents analysis, Hypoglycemic Agents pharmacology, Male, Medicine, East Asian Traditional, Organ Size drug effects, Rats, Rats, Sprague-Dawley, Weight Gain drug effects, Agaricales chemistry, Biopolymers therapeutic use, Diabetes Mellitus, Experimental drug therapy, Ganoderma chemistry, Hypoglycemic Agents therapeutic use
- Abstract
The hypoglycemic effects of Ganoderma applanatum exo-polymer (GAE) and Collybia confluens exo-polymer (CCE) produced by submerged mycelial cultures in streptozotocin (STZ)-induced diabetic rats were investigated. Hypoglycemic effects were achieved in both the GAE- and CCE-treated groups by administration at a level of 100 mg/kg body weight (BW) daily for 3 weeks. The administration of GAE and CCE substantially reduced the plasma glucose levels by as much as 22.0% and 25.9%, respectively, when compared with the control group. The GAE and CCE also lowered the plasma total cholesterol and triglyceride levels by 20.3% and 22.5%, and by 22.7% and 25.5%, respectively. Furthermore, the activity of alanine transaminase (ALT) and aspartate transaminase (AST) was decreased by 23.2% and 20.7% in the GAE-treated group, and it was also reduced by 28.7% and 23.6% in the CCE-treated group. The results strongly demonstrate the potential of GAE and CCE in combating diabetes in experimental animals., (Copyright (c) 2007 John Wiley & Sons, Ltd.)
- Published
- 2007
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