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Hypoglycemic effect of a Lentinus edodes exo-polymer produced from a submerged mycelial culture.
- Source :
-
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2002 May; Vol. 66 (5), pp. 937-42. - Publication Year :
- 2002
-
Abstract
- The hypoglycemic effect of an exo-polymer produced from a submerged mycelial culture of Lentinus edodes was investigated in streptozotocin-induced diabetic rats. The administration of the exo-polymer (200 mg/kg BW) reduced the plasma glucose level by as much as 21.5%, and increased plasma insulin by 22.1% as compared to the control group. It also lowered the plasma total cholesterol and triglyceride levels by 25.1 and 44.5%, respectively. Gel chromatography of the exo-polymer revealed a single peak which is likely to have been a glycoprotein with a molecular weight of 52 kDa and was found to contain 83.5% carbohydrate and 16.5% protein. The Sugar and amino acid compositions of the exo-polymer were analyzed in detail.
- Subjects :
- Administration, Oral
Alanine Transaminase blood
Animals
Aspartate Aminotransferases blood
Biopolymers chemistry
Biopolymers isolation & purification
Biopolymers pharmacology
Blood Glucose analysis
Body Weight drug effects
Chromatography, Gel
Diabetes Mellitus, Experimental drug therapy
Feeding Behavior drug effects
Hypoglycemic Agents chemistry
Hypoglycemic Agents isolation & purification
Hypoglycemic Agents pharmacology
Male
Rats
Rats, Sprague-Dawley
Streptozocin
Biopolymers therapeutic use
Hypoglycemic Agents therapeutic use
Shiitake Mushrooms chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0916-8451
- Volume :
- 66
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Bioscience, biotechnology, and biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 12092843
- Full Text :
- https://doi.org/10.1271/bbb.66.937