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Hypolipidemic effect of an Exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus.
- Source :
-
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2003 Jun; Vol. 67 (6), pp. 1292-8. - Publication Year :
- 2003
-
Abstract
- The hypolipidemic effect of an exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus was investigated in dietary-induced hyperlipidemic rats. Hypolipidemic effects were proportionally increased with the increasing concentration of the exo-biopolymer for oral administration. The exo-biopolymer, at the dose of 200 mg/kg body weight, substantially reduced the plasma total cholesterol (32.9%), LDL cholesterol (45.4%), triglyceride (34.3%), phospholipid (18.9%), atherogenic index (58.7%), and hepatic HMG-CoA reductase activity (20.2%). It increased the plasma HDL cholesterol level (31.1%) as compared to the control group. The molecular mass of this exo-biopolymer measured by HPLC was under 40 kDa. Total sugar and protein contents were 91.2 and 8.8%, respectively. The sugar and amino acid compositions of the exo-biopolymer were analyzed in detail.
- Subjects :
- Amino Acids analysis
Animals
Biopolymers administration & dosage
Biopolymers chemistry
Biopolymers isolation & purification
Carbohydrates analysis
Dose-Response Relationship, Drug
Hydroxymethylglutaryl CoA Reductases metabolism
Hyperlipidemias drug therapy
Hypolipidemic Agents administration & dosage
Hypolipidemic Agents isolation & purification
Lipids blood
Male
Molecular Weight
Mycelium
Rats
Rats, Sprague-Dawley
Agaricales chemistry
Agaricales growth & development
Biopolymers pharmacology
Hypolipidemic Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0916-8451
- Volume :
- 67
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Bioscience, biotechnology, and biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 12843656
- Full Text :
- https://doi.org/10.1271/bbb.67.1292