1. WNT-Regulated Transcriptional Enhancers and Stem Cell Plasticity
- Author
-
Yaser Atlasi and Fatemeh Mirzadeh Azad
- Subjects
0303 health sciences ,Stem Cells ,Cell Plasticity ,Wnt signaling pathway ,Cancer ,Cell Differentiation ,Cell Biology ,Biology ,medicine.disease_cause ,medicine.disease ,Cell biology ,03 medical and health sciences ,0302 clinical medicine ,Enhancer Elements, Genetic ,medicine ,Stem cell ,Enhancer ,Carcinogenesis ,Reprogramming ,Wnt Signaling Pathway ,030217 neurology & neurosurgery ,030304 developmental biology - Abstract
Enhancer reprogramming lies at the heart of dynamic cellular processes such as differentiation and tumorigenesis. WNT signaling is an evolutionary conserved pathway that exploits transcriptional enhancers to control the state-specific transcriptional program. Recent evidences suggest several mechanisms that govern this state-specific enhancer regulation in stem cells and cancer.
- Published
- 2021