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The interplay of epigenetic marks during stem cell differentiation and development
- Source :
- Nature Reviews. Genetics, 18, pp. 643-659, Nature Reviews. Genetics, 18, 643-659
- Publication Year :
- 2017
-
Abstract
- Chromatin, the template for epigenetic regulation, is a highly dynamic entity that is constantly reshaped during early development and differentiation. Epigenetic modification of chromatin provides the necessary plasticity for cells to respond to environmental and positional cues, and enables the maintenance of acquired information without changing the DNA sequence. The mechanisms involve, among others, chemical modifications of chromatin, changes in chromatin constituents and reconfiguration of chromatin interactions and 3D structure. New advances in genome-wide technologies have paved the way towards an integrative view of epigenome dynamics during cell state transitions, and recent findings in embryonic stem cells highlight how the interplay between different epigenetic layers reshapes the transcriptional landscape.
- Subjects :
- 0301 basic medicine
Cellular differentiation
Human Embryonic Stem Cells
Cell Differentiation
Cell state
Epigenome
Biology
Chromatin Assembly and Disassembly
Embryonic stem cell
Chromatin
Epigenesis, Genetic
03 medical and health sciences
030104 developmental biology
Genetics
Animals
Humans
Epigenetics
Neuroscience
Molecular Biology
Genetics (clinical)
Genome-Wide Association Study
Epigenesis
Subjects
Details
- ISSN :
- 14710056
- Database :
- OpenAIRE
- Journal :
- Nature Reviews. Genetics, 18, pp. 643-659, Nature Reviews. Genetics, 18, 643-659
- Accession number :
- edsair.doi.dedup.....a1421a99822381bdbf1c93dd8d7236df