1. Gut microbiota and bone metabolism
- Author
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Xiaoxuan Chen, Lingyun Lu, Yi Liu, and Xijie Yu
- Subjects
0301 basic medicine ,Osteoporosis ,Disease ,Biology ,Gut flora ,Bioinformatics ,Biochemistry ,Bone health ,Bone and Bones ,Bone remodeling ,03 medical and health sciences ,0302 clinical medicine ,Genetics ,medicine ,Animals ,Homeostasis ,Humans ,Molecular Biology ,Pathogen-associated molecular pattern ,biology.organism_classification ,medicine.disease ,Gastrointestinal Microbiome ,Crosstalk (biology) ,030104 developmental biology ,Bone Remodeling ,030217 neurology & neurosurgery ,Biotechnology - Abstract
Osteoporosis is the most common metabolic skeletal disease. It is characterized by the deterioration of the skeletal microarchitecture and bone loss, leading to ostealgia, and even bone fractures. Accumulating evidence has indicated that there is an inextricable relationship between the gut microbiota (GM) and bone homeostasis involving host-microbiota crosstalk. Any perturbation of the GM can play an initiating and reinforcing role in disrupting the bone remodeling balance during the development of osteoporosis. Although the GM is known to influence bone metabolism, the mechanisms associated with these effects remain unclear. Herein, we review the current knowledge of how the GM affects bone metabolism in health and disease, summarize the correlation between pathogen-associated molecular patterns of GM structural components and bone metabolism, and discuss the potential mechanisms underlying how GM metabolites regulate bone turnover. Deciphering the complicated relationship between the GM and bone health will provide new insights into the prevention and treatment of osteoporosis.
- Published
- 2021