1. Implications of specific gene expression patterns in enamel knot in tooth development
- Author
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Wern-Joo Sohn, Sanjiv Neupane, Seo-Young An, Tae-Young Kim, Jung-Hong Ha, KimJi-Youn, Chang-Hyeon An, Seo Jo-Young, Kim, Jae Young, Eui-Seon Lee, Yam Prasad Aryal, and Lee Youngkyun
- Subjects
0301 basic medicine ,Molar ,Embryogenesis ,Organogenesis ,030206 dentistry ,Biology ,Epithelium ,Enamel knot ,Cell biology ,stomatognathic diseases ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,stomatognathic system ,Gene expression ,medicine ,Epithelial tissue ,Gene - Abstract
Enamel knot (EK)—a signaling center—refers to a transient morphological structure comprising epithelial tissue. EK is believed to regulate tooth development in early organogenesis without its own cellular alterations, including proliferation and differentiation. EKs show a very simple but conserved structure and share functions with teeth of recently evolved vertebrates, suggesting conserved signaling in certain organs, such as functional teeth, through the course of evolution. In this study, we examined the expression patterns of key EK-specific genes including Dusp26 , Fat4, Meis2, Sln , and Zpld1 during mice embryogenesis. Expression patterns of these genes may reveal putative differentiation mechanisms underlying tooth morphogenesis.
- Published
- 2020