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Resveratrol enhances bone formation by modulating inflammation in the mouse periodontitis model
- Source :
- Journal of periodontal researchREFERENCES. 56(4)
- Publication Year :
- 2021
-
Abstract
- Objective To evaluate the effect of resveratrol on periodontal bone regeneration after local delivery and to determine its effect on inflammatory mediators. Background Resveratrol is considered an anti-inflammatory polyphenolic stilbene involved in the modulation of inflammation. Materials and methods Periodontitis was induced in mouse molars using a 5-day ligature model followed by the left second molar extraction and 50 µM resveratrol treatment for 1 and 2 weeks. We then examined specimens treated for 1 week histologically and with immunostaining. Microfocus-computed tomography (micro-CT) was used to examine the bone volume formation. Results After 1 week of treatment, proinflammatory cytokine levels (TNF-alpha and IL6), cells exhibiting neutrophil and macrophage marker (MPO), cell proliferation marker (Ki67), and preosteoblastic marker (RUNX2) reactivity decreased in the resveratrol-treated specimens compared to the control group. In contrast, we observed a higher number of CD31-, F4/80-, and osteocalcin- (OCN-) positive cells in the resveratrol-treated specimens. After 2 weeks, micro-CT confirmed an increased bone mass in the region of the extraction socket in the resveratrol-treated group. Conclusion After 1 week, the resveratrol-treated specimens revealed evidence of inflammation modulation compared to the control group. These data suggest that resveratrol not only affects inflammation control but also is useful for treating periodontitis-related tissue defects and bone regeneration.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
medicine.medical_treatment
Alveolar Bone Loss
Inflammation
Resveratrol
Proinflammatory cytokine
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
Osteogenesis
Internal medicine
medicine
Animals
Bone regeneration
Periodontitis
biology
Chemistry
030206 dentistry
medicine.disease
Disease Models, Animal
030104 developmental biology
Endocrinology
Cytokine
Osteocalcin
biology.protein
Periodontics
medicine.symptom
Immunostaining
Subjects
Details
- ISSN :
- 16000765
- Volume :
- 56
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of periodontal researchREFERENCES
- Accession number :
- edsair.doi.dedup.....bc7dda81daf0399a58d34c5a1fed46ab