1. Immune variations throughout the course of tuberculosis treatment and its relationship with adrenal hormone changes in HIV-1 patients co-infected with Mycobacterium tuberculosis
- Author
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Graciela Ben, Matias Tomas Angerami, María Florencia Quiroga, Natalia Laufer, Luis D. Giavedoni, Omar Sued, Gabriela Turk, Diego Ameri, Patricia Maidana, Diego Gonzalez, Guadalupe Verónica Suarez, Laura M. Parodi, Viviana Mesch, Bibiana Fabre, and María Belén Vecchione
- Subjects
0301 basic medicine ,Male ,Chemokine ,Time Factors ,Hydrocortisone ,Antitubercular Agents ,HIV Infections ,Systemic inflammation ,T-Lymphocytes, Regulatory ,Adrenal Cortex Hormones ,Prospective Studies ,biology ,Coinfection ,Dehydroepiandrosterone Sulfate ,Middle Aged ,Infectious Diseases ,medicine.anatomical_structure ,Treatment Outcome ,Host-Pathogen Interactions ,Cytokines ,Female ,medicine.symptom ,hormones, hormone substitutes, and hormone antagonists ,Microbiology (medical) ,Adult ,Tuberculosis ,Regulatory T cell ,030106 microbiology ,Immunology ,Microbiology ,Article ,Mycobacterium tuberculosis ,03 medical and health sciences ,Immune system ,medicine ,Humans ,Risk factor ,business.industry ,Dehydroepiandrosterone ,medicine.disease ,biology.organism_classification ,030104 developmental biology ,biology.protein ,HIV-1 ,business ,Biomarkers ,Hormone - Abstract
HIV infection is a major risk factor predisposing for Mycobacterium tuberculosis infection and progression to active tuberculosis (TB). As host immune response defines the course of infection, we aimed to identify immuno-endocrine changes over six-months of anti-TB chemotherapy in HIV+ people. Plasma levels of cortisol, DHEA and DHEA-S, percentages of CD4+ regulatory T cell subsets and number of IFN-γ-secreting cells were determined. Several cytokines, chemokines and C-reactive protein levels were measured. Results were correlated with clinical parameters as predictors of infection resolution and compared to similar data from HIV+ individuals, HIV-infected persons with latent TB infection and healthy donors. Throughout the course of anti-TB/HIV treatment, DHEA and DHEA-S plasma levels raised while cortisol diminished, which correlated to predictive factors of infection resolution. Furthermore, the balance between cortisol and DHEA, together with clinical assessment, may be considered as an indicator of clinical outcome after anti-TB treatment in HIV+ individuals. Clinical improvement was associated with reduced frequency of unconventional Tregs, increment in IFN-γ-secreting cells, diminution of systemic inflammation and changes of circulating cytokines and chemokines. This study suggests that the combined anti-HIV/TB therapies result in partial restoration of both, immune function and adrenal hormone plasma levels.
- Published
- 2020