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Cross‐Talk between CD31 and the Signaling Lymphocytic Activation Molecule–Associated Protein during Interferon‐γ Production againstMycobacterium tuberculosis
- Source :
- The Journal of Infectious Diseases. 196:1369-1378
- Publication Year :
- 2007
- Publisher :
- Oxford University Press (OUP), 2007.
-
Abstract
- Effective host defense against tuberculosis requires Th1 cytokine responses. We studied the regulation of interferon (IFN)- gamma production during tuberculosis by investigating the role of CD31, a receptor that attenuates T cell receptor signals. After antigen stimulation, CD3(+)CD31(+) blood lymphocytes decreased in healthy donors and in tuberculosis patients with robust Th1 responses to Mycobacterium tuberculosis and IFN- gamma was secreted only by CD31(-) T cells. In contrast, in patients with weak Th1 cytokine responses to M. tuberculosis, the level of CD3(+)CD31(+) lymphocytes was increased and IFN- gamma production was low. Furthermore, the inverse relationship between CD31 expression and IFN- gamma production was in contrast to signaling lymphocytic activation molecule (SLAM) expression, an IFN- gamma inducer in tuberculosis. Interestingly, CD31 bound to SLAM-associated protein (SAP), an IFN- gamma inhibitor in tuberculosis, and when CD31 and SAP were coexpressed in lymphocytes, their association inhibited the IFN- gamma response to M. tuberculosis. Thus, CD31, when binding to SAP, interferes with Th1 responses, suggesting that CD31 has a key regulatory role in the signaling pathway(s) leading to the IFN- gamma response to M. tuberculosis.
- Subjects :
- Tuberculosis
T-Lymphocytes
CD3
medicine.medical_treatment
Biology
Mycobacterium tuberculosis
Interferon-gamma
Signaling lymphocytic activation molecule
Interferon
medicine
Humans
Immunology and Allergy
Interferon gamma
Signaling Lymphocytic Activation Molecule Associated Protein
Tuberculosis, Pulmonary
T-cell receptor
Intracellular Signaling Peptides and Proteins
medicine.disease
biology.organism_classification
Platelet Endothelial Cell Adhesion Molecule-1
Infectious Diseases
Cytokine
Gene Expression Regulation
Immunology
cardiovascular system
biology.protein
Signal Transduction
medicine.drug
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 196
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....7800518c8615c7328188713819019827