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Expression of Signaling Lymphocytic Activation Molecule- Associated Protein Interrupts IFN-γ Production in Human Tuberculosis
- Source :
- The Journal of Immunology. 172:1177-1185
- Publication Year :
- 2004
- Publisher :
- The American Association of Immunologists, 2004.
-
Abstract
- Production of the Th1 cytokine IFN-γ by T cells is considered crucial for immunity against Mycobacterium tuberculosis infection. We evaluated IFN-γ production in tuberculosis in the context of signaling molecules known to regulate Th1 cytokines. Two populations of patients who have active tuberculosis were identified, based on their T cell responses to the bacterium. High responder tuberculosis patients displayed significant M. tuberculosis-dependent T cell proliferation and IFN-γ production, whereas low responder tuberculosis patients displayed weak or no T cell responses to M. tuberculosis. The expression of the signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) on cells from tuberculosis patients was inversely correlated with IFN-γ production in those individuals. Moreover, patients with a nonfunctional SAP gene displayed immune responses to M. tuberculosis similar to those of high responder tuberculosis patients. In contrast to SAP, T cell expression of SLAM was directly correlated with responsiveness to M. tuberculosis Ag. Our data suggest that expression of SAP interferes with Th1 responses whereas SLAM expression contributes to Th1 cytokine responses in tuberculosis. The study further suggests that SAP and SLAM might be focal points for therapeutic modulation of T cell cytokine responses in tuberculosis.
- Subjects :
- Cell signaling
Tuberculosis
medicine.medical_treatment
T cell
Immunology
Down-Regulation
Immunoglobulins
Receptors, Cell Surface
Context (language use)
Ligands
Severity of Illness Index
Mycobacterium tuberculosis
Interferon-gamma
Immune system
Signaling lymphocytic activation molecule
Adjuvants, Immunologic
Signaling Lymphocytic Activation Molecule Family Member 1
Antigens, CD
medicine
Humans
Immunology and Allergy
Signaling Lymphocytic Activation Molecule Associated Protein
Cells, Cultured
Glycoproteins
Chromosomes, Human, X
Immunity, Cellular
biology
Intracellular Signaling Peptides and Proteins
Antibodies, Monoclonal
medicine.disease
biology.organism_classification
Interleukin-12
Lymphoproliferative Disorders
Up-Regulation
Cytokine
medicine.anatomical_structure
Carrier Proteins
Signal Transduction
Subjects
Details
- ISSN :
- 15506606 and 00221767
- Volume :
- 172
- Database :
- OpenAIRE
- Journal :
- The Journal of Immunology
- Accession number :
- edsair.doi.dedup.....dd901e2fca335efcca9576f466af59e2