1. Supplementation of a Fermented Soybean Extract Reduces Body Mass and Prevents Obesity in High Fat Diet-Induced C57BL/6J Obese Mice
- Author
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Kwontack Hwang, Su-Il Seong, Jae Yeon Lee, Adithan Aravinthan, Young Shik Park, and Kyo Yeol Hwang
- Subjects
0301 basic medicine ,obesity ,medicine.medical_specialty ,Antioxidant ,Lipid accumulation ,glucose metabolism ,medicine.medical_treatment ,Adipose tissue ,Bacillus subtilis ,Carbohydrate metabolism ,Biology ,03 medical and health sciences ,0302 clinical medicine ,antioxidant enzymes ,Internal medicine ,medicine ,chemistry.chemical_classification ,Nutrition and Dietetics ,lipid accumulation ,Articles ,medicine.disease ,biology.organism_classification ,Obesity ,030104 developmental biology ,Endocrinology ,Enzyme ,chemistry ,030211 gastroenterology & hepatology ,Fermentation ,fermented soybean extracts ,Food Science - Abstract
Obesity is a growing health problem that many countries face, mostly due to the consumption of a Westernized diet. In this present study we observed the effects of a soybean extract fermented by Bacillus subtilis MORI (BTD-1) containing 1-deoxynojirimycin against high fat diet-induced obesity. The results obtained from this study indicated that BTD-1 reduced body weight, regulated hepatic lipid content and adipose tissue, and also affected liver antioxidant enzymes and glucose metabolism. These results suggest that administration of BTD-1 affects obesity by inhibiting hyperglycemia and free radical-mediated stress; it also reduces lipid accumulation. Therefore, BTD-1 may be potentially useful for the prevention of obesity and its related secondary complications.
- Published
- 2016