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Fermented soy bean extract suppresses differentiation of 3T3-L1 preadipocytes and facilitates its glucose utilization
- Source :
- Journal of Functional Foods, Vol 15, Iss, Pp 516-524 (2015)
- Publication Year :
- 2015
- Publisher :
- Elsevier, 2015.
-
Abstract
- Obesity is a serious health problem which may continuously increase the morbidity and mortality associated with a variety of acute and chronic diseases.This study aimed to examine the antiobesity effect of soy bean extract fermented by Bacillus subtilis MORI (BTD-1) and to elucidate the mechanisms underlying such effects using 3T3-L1 preadipocytes. Lipid accumulations were significantly inhibited by BTD-1 treatment, which were accompanied by the decreased expression of CCAAT element binding protein α (C/EBPα) and the increased phosphorylation of acetyl-CoA carboxylase (ACC) protein expression. In addition, BTD-1 treatment increased the expression of glucose transporter 4 (GLUT4) along with significantly increasing glucose uptake into the adipocytes based on results of a 2-deoxy-D-[3H] glucose uptake assay. Our findings suggest that BTD-1 may suppress the differentiation of 3T3-L1 adipocytes and greatly facilitate glucose uptake into the adipocytes. Therefore, BTD-1 has a potential as a functional food ingredient in improving obesity and related metabolic disorders.
- Subjects :
- medicine.medical_specialty
Nutrition and Dietetics
Adipogenesis
Nutrition. Foods and food supply
Glucose uptake
Glucose transporter
Medicine (miscellaneous)
3T3-L1
Biology
Pyruvate carboxylase
C/EBPα
Endocrinology
Functional food
Soy bean extract
Internal medicine
medicine
biology.protein
Phosphorylation
TX341-641
ACC
GLUT4
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 17564646
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Journal of Functional Foods
- Accession number :
- edsair.doi.dedup.....9704a048200e10a26c109adaa3d740e4