1. An assembly of galanin–galanin receptor signaling network
- Author
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Lathika Gopalakrishnan, Oishi Chatterjee, Deepshika Pullimamidi, Jayshree Advani, Chinmayi Raj, Anita Mahadevan, and T. S. Keshava Prasad
- Subjects
0301 basic medicine ,Regulation of gene expression ,endocrine system ,Nuts and Bolts ,WikiPathways : Pathways for the people ,digestive, oral, and skin physiology ,Central nervous system ,Neuropeptide ,Galanin receptor ,Cell Biology ,Biology ,Biochemistry ,Biological pathway ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,nervous system ,030220 oncology & carcinogenesis ,medicine ,Galanin ,Receptor ,Molecular Biology ,Neuroscience - Abstract
The galanin receptor family of proteins is present throughout the central nervous system and endocrine system. It comprises of three subtypes—GalR1, GalR2, and GalR3; all of which are G-protein-coupled receptors. Galanin predominantly acts as an inhibitory, hyper-polarizing neuromodulator, which has several physiological as well as pathological functions. Galanin has a role in mediating food intake, memory, sexual behavior, nociception and is also associated with diseases such as Alzheimer’s disease, epilepsy, diabetes mellitus, and chronic pain. However, the understanding of signaling mechanisms of the galanin family of neuropeptides is limited and an organized pathway map is not yet available. Therefore, a detailed literature mining of the publicly available articles pertaining to the galanin receptor was followed by manual curation of the reactions and their integration into a map. This resulted in the cataloging of molecular reactions involving 64 molecules into five categories such as molecular association, activation/inhibition, catalysis, transport, and gene regulation. For enabling easy access of biomedical researchers, the galanin–galanin receptor signaling pathway data was uploaded to WikiPathways (https://www.wikipathways.org/index.php/Pathway:WP4970), a freely available database of biological pathways. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12079-020-00590-3) contains supplementary material, which is available to authorized users.
- Published
- 2020