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The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours
- Source :
- RIUMA. Repositorio Institucional de la Universidad de Málaga, instname
- Publication Year :
- 2017
-
Abstract
- Galanin is a 29 amino acid neuropeptide widely distributed in neurons within the central nervous system. Galanin exerts its biological activities through three different G protein-receptors and participates in a number of functions, including mood regulation. Not only Galanin but also Galanin N-terminal fragments like Galanin(1-15) are active at the central level. In this work, we review the latest findings in studies on Galanin and Galanin(1-15) in depression-related behaviours. Our focus is on animal models for depression, and we pay some attention to research data obtained in human studies. Since Serotonin (5-HT), especially through 5-HT1A, and Galanin receptors interact at both pre-and postsynaptic level, the development of drugs targeting potential GAL1-GAL2-5-HT1A heteroreceptor complexes linked to the raphe-hippocampal 5-HT neurons may represent new treatment strategies in depression.
- Subjects :
- 0301 basic medicine
Central Nervous System
endocrine system
medicine.medical_specialty
Depresión mental
Central nervous system
Neuropeptide
Galanin receptor
Galanin
Biology
Heteroreceptor
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Endocrinology
Postsynaptic potential
Internal medicine
medicine
Animals
Humans
Receptor
Galanin (1-15)
Depressive Disorder
Endocrine and Autonomic Systems
Depression
digestive, oral, and skin physiology
Neuropeptides
Neuropéptidos
General Medicine
030104 developmental biology
medicine.anatomical_structure
nervous system
Neurology
Medicamentos
Serotonin
Neuroscience
Receptors, Galanin
hormones, hormone substitutes, and hormone antagonists
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- RIUMA. Repositorio Institucional de la Universidad de Málaga, instname
- Accession number :
- edsair.doi.dedup.....f03ae32686643780a8e67a70160dc8e2