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Your search keyword '"Nick Macdonald"' showing total 4 results
Start Over Author "Nick Macdonald" Topic biological sciences
4 results on '"Nick Macdonald"'

1. Ecological and Evolutionary Consequences of Anticancer Adaptations

Author

Justine Boutry, Antoine M. Dujon, Anne-Lise Gerard, Sophie Tissot, Nick Macdonald, Aaron Schultz, Peter A. Biro, Christa Beckmann, Rodrigo Hamede, David G. Hamilton, Mathieu Giraudeau, Beata Ujvari, and Frédéric Thomas

Subjects
Biological Sciences, Evolutionary Biology, Evolutionary Ecology, Cancer Systems Biology, Science
Abstract

Summary: Cellular cheating leading to cancers exists in all branches of multicellular life, favoring the evolution of adaptations to avoid or suppress malignant progression, and/or to alleviate its fitness consequences. Ecologists have until recently largely neglected the importance of cancer cells for animal ecology, presumably because they did not consider either the potential ecological or evolutionary consequences of anticancer adaptations. Here, we review the diverse ways in which the evolution of anticancer adaptations has significantly constrained several aspects of the evolutionary ecology of multicellular organisms at the cell, individual, population, species, and ecosystem levels and suggest some avenues for future research.

Published
2020
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2. Transmissible Cancers in an Evolutionary Perspective

Author

Antoine M. Dujon, Robert A. Gatenby, Georgina Bramwell, Nick MacDonald, Erin Dohrmann, Nynke Raven, Aaron Schultz, Rodrigo Hamede, Anne-Lise Gérard, Mathieu Giraudeau, Frédéric Thomas, and Beata Ujvari

Subjects
Biological Sciences, Evolutionary Biology, Evolutionary Ecology, Cancer, Science
Abstract

Inter-individual transmission of cancer cells represents an intriguing and unexplored host-pathogen system, with significant ecological and evolutionary ramifications. The pathogen consists of clonal malignant cell lines that spread horizontally as allografts and/or xenografts. Although only nine transmissible cancer lineages in eight host species from both terrestrial and marine environments have been investigated, they exhibit evolutionary dynamics that may provide novel insights into tumor-host interactions particularly in the formation of metastases. Here we present an overview of known transmissible cancers, discuss the necessary and sufficient conditions for cancer transmission, and provide a comprehensive review on the evolutionary dynamics between transmissible cancers and their hosts.

Published
2020
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3. Ecological and Evolutionary Consequences of Anticancer Adaptations

Author

Mathieu Giraudeau, Sophie Tissot, Antoine M. Dujon, Aaron G. Schultz, Anne-Lise Gerard, David G. Hamilton, Rodrigo Hamede, Justine Boutry, Beata Ujvari, Nick Macdonald, Péter Biró, Christa Beckmann, F. Thomas, Centre de Recherches Ecologiques et Evolutives sur le Cancer (MIVEGEC-CREEC), Processus Écologiques et Évolutifs au sein des Communautés (PEEC), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Deakin University [Burwood], Hawkesbury Institute for the Environment [Richmond] (HIE), Western Sydney University, University of Tasmania [Hobart, Australia] (UTAS), and ANR-18-CE35-0009,TRANSCAN,ECOLOGIE ET EVOLUTION DES CANCERS TRANSMISSIBLES(2018)

Subjects
0301 basic medicine, Cheating, [SDV]Life Sciences [q-bio], Population, Cell, Review, 02 engineering and technology, Biology, 03 medical and health sciences, medicine, 14. Life underwater, education, lcsh:Science, education.field_of_study, Evolutionary Biology, Multidisciplinary, Ecology, Biological Sciences, 021001 nanoscience & nanotechnology, Multicellular organism, 030104 developmental biology, medicine.anatomical_structure, Animal ecology, Evolutionary Ecology, Cancer systems biology, Evolutionary ecology, lcsh:Q, Malignant progression, 0210 nano-technology, Cancer Systems Biology
Abstract

Summary Cellular cheating leading to cancers exists in all branches of multicellular life, favoring the evolution of adaptations to avoid or suppress malignant progression, and/or to alleviate its fitness consequences. Ecologists have until recently largely neglected the importance of cancer cells for animal ecology, presumably because they did not consider either the potential ecological or evolutionary consequences of anticancer adaptations. Here, we review the diverse ways in which the evolution of anticancer adaptations has significantly constrained several aspects of the evolutionary ecology of multicellular organisms at the cell, individual, population, species, and ecosystem levels and suggest some avenues for future research., Graphical Abstract, Biological Sciences; Evolutionary Biology; Evolutionary Ecology; Cancer Systems Biology

Published
2020
Full Text
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4. Transmissible Cancers in an Evolutionary Perspective

Author

F. Thomas, Antoine M. Dujon, Georgina Bramwell, Robert A. Gatenby, Beata Ujvari, Aaron G. Schultz, Mathieu Giraudeau, Nynke Raven, Nick Macdonald, Erin Dohrmann, Rodrigo Hamede, Anne-Lise Gerard, Deakin University, Burwood, Australia, Deakin University [Burwood], H. Lee Moffitt Cancer Center and Research Institute, University of Tasmania [Hobart, Australia] (UTAS), Centre de Recherches Ecologiques et Evolutives sur le Cancer (MIVEGEC-CREEC), Processus Écologiques et Évolutifs au sein des Communautés (PEEC), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), and ANR-18-CE35-0009,TRANSCAN,ECOLOGIE ET EVOLUTION DES CANCERS TRANSMISSIBLES(2018)

Subjects
0301 basic medicine, [SDV]Life Sciences [q-bio], Review, 02 engineering and technology, Biology, 03 medical and health sciences, medicine, Malignant cells, Evolutionary dynamics, lcsh:Science, Biological sciences, Cancer, Evolutionary Biology, Multidisciplinary, Transmission (medicine), Biological Sciences, 021001 nanoscience & nanotechnology, medicine.disease, 3. Good health, 030104 developmental biology, Evolutionary biology, Evolutionary Ecology, Cancer cell, Evolutionary ecology, lcsh:Q, 0210 nano-technology
Abstract

Inter-individual transmission of cancer cells represents an intriguing and unexplored host-pathogen system, with significant ecological and evolutionary ramifications. The pathogen consists of clonal malignant cell lines that spread horizontally as allografts and/or xenografts. Although only nine transmissible cancer lineages in eight host species from both terrestrial and marine environments have been investigated, they exhibit evolutionary dynamics that may provide novel insights into tumor-host interactions particularly in the formation of metastases. Here we present an overview of known transmissible cancers, discuss the necessary and sufficient conditions for cancer transmission, and provide a comprehensive review on the evolutionary dynamics between transmissible cancers and their hosts., Graphical Abstract, Biological Sciences; Evolutionary Biology; Evolutionary Ecology; Cancer

Published
2020
Full Text
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