Back to Search Start Over

Transmissible Cancers in an Evolutionary Perspective

Authors :
Antoine M. Dujon
Robert A. Gatenby
Georgina Bramwell
Nick MacDonald
Erin Dohrmann
Nynke Raven
Aaron Schultz
Rodrigo Hamede
Anne-Lise Gérard
Mathieu Giraudeau
Frédéric Thomas
Beata Ujvari
Source :
iScience, Vol 23, Iss 7, Pp 101269- (2020)
Publication Year :
2020
Publisher :
Elsevier, 2020.

Abstract

Inter-individual transmission of cancer cells represents an intriguing and unexplored host-pathogen system, with significant ecological and evolutionary ramifications. The pathogen consists of clonal malignant cell lines that spread horizontally as allografts and/or xenografts. Although only nine transmissible cancer lineages in eight host species from both terrestrial and marine environments have been investigated, they exhibit evolutionary dynamics that may provide novel insights into tumor-host interactions particularly in the formation of metastases. Here we present an overview of known transmissible cancers, discuss the necessary and sufficient conditions for cancer transmission, and provide a comprehensive review on the evolutionary dynamics between transmissible cancers and their hosts.

Details

Language :
English
ISSN :
25890042
Volume :
23
Issue :
7
Database :
Directory of Open Access Journals
Journal :
iScience
Publication Type :
Academic Journal
Accession number :
edsdoj.395a8635e1c44a3192502c60fff5d94a
Document Type :
article
Full Text :
https://doi.org/10.1016/j.isci.2020.101269