Start Over

Transmissible Cancers in an Evolutionary Perspective

Authors :: F. Thomas
Antoine M. Dujon
Georgina Bramwell
Robert A. Gatenby
Beata Ujvari
Aaron G. Schultz
Mathieu Giraudeau
Nynke Raven
Nick Macdonald
Erin Dohrmann
Rodrigo Hamede
Anne-Lise Gerard
Deakin University, Burwood, Australia
Deakin University [Burwood]
H. Lee Moffitt Cancer Center and Research Institute
University of Tasmania [Hobart, Australia] (UTAS)
Centre de Recherches Ecologiques et Evolutives sur le Cancer (MIVEGEC-CREEC)
Processus Écologiques et Évolutifs au sein des Communautés (PEEC)
Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC)
Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC)
Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])
ANR-18-CE35-0009,TRANSCAN,ECOLOGIE ET EVOLUTION DES CANCERS TRANSMISSIBLES(2018)
Source :: iScience, iScience, 2020, 23 (7), pp.101269. ⟨10.1016/j.isci.2020.101269⟩, iScience, Vol 23, Iss 7, Pp 101269-(2020), iScience, Elsevier, 2020, 23 (7), pp.101269. ⟨10.1016/j.isci.2020.101269⟩
Publication Year :: 2020
Publisher :: HAL CCSD, 2020.
Abstract: Inter-individual transmission of cancer cells represents an intriguing and unexplored host-pathogen system, with significant ecological and evolutionary ramifications. The pathogen consists of clonal malignant cell lines that spread horizontally as allografts and/or xenografts. Although only nine transmissible cancer lineages in eight host species from both terrestrial and marine environments have been investigated, they exhibit evolutionary dynamics that may provide novel insights into tumor-host interactions particularly in the formation of metastases. Here we present an overview of known transmissible cancers, discuss the necessary and sufficient conditions for cancer transmission, and provide a comprehensive review on the evolutionary dynamics between transmissible cancers and their hosts.<br />Graphical Abstract<br />Biological Sciences; Evolutionary Biology; Evolutionary Ecology; Cancer

Details

Language :: English
ISSN :: 25890042
Database :: OpenAIRE
Journal :: iScience, iScience, 2020, 23 (7), pp.101269. ⟨10.1016/j.isci.2020.101269⟩, iScience, Vol 23, Iss 7, Pp 101269-(2020), iScience, Elsevier, 2020, 23 (7), pp.101269. ⟨10.1016/j.isci.2020.101269⟩
Accession number :: edsair.doi.dedup.....90ce5666b894983dccc301149d48ebae
Full Text :: https://doi.org/10.1016/j.isci.2020.101269⟩