1. Long-term outcomes after transcatheter aortic valve replacement in nonagenarians: a multicenter age-based analysis.
- Author
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Costa G, Valvo R, Fiorina C, Adamo M, Giannini C, Testa L, Bruschi G, Poli A, De Felice F, Montorfano M, Maffeo D, Iadanza A, Reimers B, Bedogni F, Petronio AS, Tamburino C, and Barbanti M
- Subjects
- Age Factors, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Incidence, Italy epidemiology, Male, Prospective Studies, Prosthesis Design, Risk Assessment, Survival Rate trends, Time Factors, Aortic Valve surgery, Aortic Valve Stenosis surgery, Heart Valve Prosthesis, Nonagenarians statistics & numerical data, Postoperative Complications epidemiology, Registries, Transcatheter Aortic Valve Replacement methods
- Abstract
Aim: To assess the outcome of nonagenarians patients receiving transcatheter aortic valve replacement (TAVR)., Methods: We aimed to stratify the overall population from an Italian, multicenter, observational project including a total of 3792 consecutive patients who underwent TAVR with CoreValve and Evolut R/PRO devices between April 2009 and October 2018, into four groups according to their age class (≥90 vs. 80-89 years vs. 70-79 vs. <70 years) and to compare outcomes up to 4 years after TAVR., Results: At 4 years, survival estimates showed no difference in terms of overall survival [Kaplan-Meier estimates (KM est.) 49.9 vs. 58.1% vs. 57.0 vs. 69.3%; Plogrank = 0.28] among the four groups. After 2 years from the procedure, landmark analysis showed an age-based difference in overall survival (KM est. 63.8 vs. 75.0% vs. 75.1 vs. 88.7%; Plogrank = 0.025) but no difference in terms of survival from cardiovascular death (KM est. 87.8 vs. 87.4% vs. 86.1 vs. 96.1%; Plogrank = 0.43). Finally, age itself was not correlated with overall mortality at 4 years (hazard ratio 1.06, 95% confidence interval 0.86-1.30, P = 0.591)., Conclusion: TAVR with self-expanding CoreValve and Evolut prostheses was demonstrated to have good long-term outcomes, regardless of the patient's age. At 4 years, no difference in overall mortality was reported among age-based groups, while a higher overall mortality was reported in nonagenarians after 2 years from the procedure. TAVR showed good long-term outcomes even in nonagenarian patients, and it could be the therapy of choice for selected elderly patients., (Copyright © 2020 Italian Federation of Cardiology - I.F.C. All rights reserved.)
- Published
- 2021
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