1. Effect of SARS-CoV-2 Infection on the Microbial Composition of Upper Airway
- Author
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Changli Tu, Xiaobin Zheng, Huitao Zhang, Jing Liu, Pengfei Pang, Yingjian Liang, Zhenguo Wang, Yiming Wang, Xiaojun Hu, Hong Shan, and Zhonghe Li
- Subjects
0301 basic medicine ,Pharmacology ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Opportunistic infection ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,030106 microbiology ,Microbial composition ,macromolecular substances ,Biology ,medicine.disease ,medicine.disease_cause ,biology.organism_classification ,Microbiology ,03 medical and health sciences ,0302 clinical medicine ,Infectious Diseases ,medicine ,Pharmacology (medical) ,030212 general & internal medicine ,Airway ,Bacteria ,Coronavirus - Abstract
Methods Forty-four COVID-19 patients (severe/critical: N = 8, non-severe: N = 36) were examined by next generation sequencing (NGS) of nasopharyngeal test paper to observe the effect of novel coronavirus infection to the microbial composition in upper airway. Results In these nasopharyngeal test paper samples, 38 kinds of bacteria, 10 kinds of viruses except SARS-CoV-2, nine kinds of fungi and three kinds of atypical pathogens had been found. There was some difference in microbial composition in the upper airway between severe and non-severe cases. Summary These results are important for us to study the effect of SARS-CoV-2 on the local microbial composition of upper airway and prevent opportunistic infection in severe patients.
- Published
- 2020