1. A possible principal function of corticosteroid signaling that is conserved in vertebrate evolution: Lessons from receptor-knockout small fish
- Author
-
Susumu Hyodo, Wataru Takagi, and Tatsuya Sakamoto
- Subjects
0301 basic medicine ,medicine.drug_class ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Oryzias ,Biochemistry ,Evolution, Molecular ,Gene Knockout Techniques ,Mice ,03 medical and health sciences ,Receptors, Glucocorticoid ,0302 clinical medicine ,Endocrinology ,Mineralocorticoid receptor ,Glucocorticoid receptor ,Mineralocorticoids ,biology.animal ,medicine ,Animals ,Receptor ,Glucocorticoids ,Molecular Biology ,Zebrafish ,Gene knockout ,Behavior, Animal ,biology ,Vertebrate ,Cell Biology ,biology.organism_classification ,Cell biology ,Receptors, Mineralocorticoid ,030104 developmental biology ,Mineralocorticoid ,Molecular Medicine ,hormones, hormone substitutes, and hormone antagonists ,030217 neurology & neurosurgery ,Glucocorticoid ,medicine.drug - Abstract
Corticosteroid receptors are critical for homeostasis maintenance, but understanding of the principal roles of the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) throughout vertebrates is limited. Lines of constitutive GR-knockout zebrafish and MR-knockout medaka have recently been generated as the first adult-viable corticosteroid receptor-knockout animals, in contrast to the lethality of these receptor knockouts in mice. Here, we describe behavioral and physiological modifications following disruption of corticosteroid receptor function in these animal models. We suggest these data point toward a potentially conserved function of corticosteroid receptors in integrating brain-behavior and visual responses in vertebrates. Finally, we discuss how future work in cartilaginous fishes (Chondrichthyes) will further advance understanding of the unity and diversity of corticosteroid receptor function, since distinct orthologs of GR and MR derived from an ancestral corticoid receptor appear in these basal jawed vertebrates.
- Published
- 2018