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Secular Decreasing Trend in Plasma Eicosapentaenoic and Docosahexaenoic Acids among Patients with Acute Coronary Syndrome from 2011 to 2019: A Single Center Descriptive Study
- Source :
- Nutrients, Vol 13, Iss 253, p 253 (2021), Nutrients, Volume 13, Issue 1
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Despite intensive lipid-lowering interventions, patients treated with statins develop atherosclerotic cardiovascular disease (ASCVD), and these patients have an increased risk of developing recurrent cardiovascular events during follow-up. Therefore, there is a need to focus on the residual risks in patients in statin therapy to further reduce ASCVD. The aim of this study was to retrospectively investigate the 10-year trend (2011&ndash<br />2019) regarding changes in polyunsaturated fatty acids (PUFAs) in patients with acute coronary syndrome (ACS) in a single center. We included 686 men and 203 women with ACS admitted to Kagawa Prefectural Central Hospital. Plasma PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA), and dihomo-&gamma<br />linolenic acid (DGLA), were measured at admission for suspected ACS. A secular decreasing trend in the levels of EPA and DHA and the EPA/AA ratio, but not of AA and DGLA, was observed. The analyses based on age (&gt<br />70 or &lt<br />70 years) and sex showed that the decreasing trend in the levels of EPA and DHA did not depend on age and remained significant only in men. Further studies are needed to obtain robust evidence to justify that the administration of n-3 PUFA contributes to the secondary prevention of ACS.
- Subjects :
- Male
Acute coronary syndrome
medicine.medical_specialty
eicosapentaenoic acid
Docosahexaenoic Acids
descriptive study
lcsh:TX341-641
030204 cardiovascular system & hematology
Single Center
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
8,11,14-Eicosatrienoic Acid
Sex Factors
Internal medicine
arachidonic acid
Medicine
Humans
030212 general & internal medicine
Acute Coronary Syndrome
Aged
Retrospective Studies
chemistry.chemical_classification
Aged, 80 and over
Nutrition and Dietetics
business.industry
Atherosclerotic cardiovascular disease
Age Factors
atherosclerotic cardiovascular disease
Middle Aged
docosahexaenoic acid
medicine.disease
Eicosapentaenoic acid
Lipids
Residual risk
chemistry
Docosahexaenoic acid
Fatty Acids, Unsaturated
Arachidonic acid
Female
lipids (amino acids, peptides, and proteins)
Hydroxymethylglutaryl-CoA Reductase Inhibitors
business
lcsh:Nutrition. Foods and food supply
Food Science
Polyunsaturated fatty acid
polyunsaturated fatty acids
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 13
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....117726d98cf8d07a797b229b45d8613d