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30 results on '"J. Krimmer"'

1. Monitoring ion beam therapy with a Compton Camera: simulation studies of the clinical feasibility

Author

Etienne Testa, J.-L. Ley, I. Rinaldi, J. Krimmer, Jean Michel Létang, Mattia Fontana, M.-H. Richard, Nicolas Freud, Voichita Maxim, Denis Dauvergne, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), and Université Grenoble Alpes (UGA)

Subjects
Physics, [PHYS]Physics [physics], Particle therapy, Ion beam, business.industry, medicine.medical_treatment, Detector, Monte Carlo method, Physics::Medical Physics, Dose profile, Atomic and Molecular Physics, and Optics, Imaging phantom, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Optics, 030220 oncology & carcinogenesis, medicine, Radiology, Nuclear Medicine and imaging, business, Instrumentation, Beam (structure), Event reconstruction
Abstract

As more and more particle therapy centers are being built world-wide, there is increasing need in treatment monitoring methods, ideally in real time. This article investigates the clinical applicability of a Compton camera design by means of Monte Carlo simulations. The Compton camera performance has been studied with the simulation of point-like source and beam irradiation of a polymethyl methacrylate (PMMA) phantom. The system absolute photon detection efficiency, measured via source irradiation, varies in the range [1, 4] $\times 10^{-4}$ with energy variations in the prompt gamma (PG) energy range and source position shifts with respect to the center of the camera. With proton and carbon beams impinging on a PMMA cylindrical phantom, the number of detected PG coincidences related to various beam time structure has been studied. Finally, the accuracy of the camera in identifying the dose profile fall-off position has been estimated and two different event reconstruction methods have been compared for this purpose; one based on analytical calculation with a line-cone technique, the second relying on an iterative maximum likelihood expectation maximization algorithm. Both methods showed the possibility to reconstruct the beam depth-dose profile and to retrieve the dose fall-off with millimeter precision on a spot basis.

Published
2020

2. Study for online range monitoring with the interaction vertex imaging method

Author

J. Krimmer, Cédric Ray, J. Baudot, D. Juliani, V. Reithinger, Etienne Testa, M. Vanstalle, Julie Constanzo, Y. Karakaya, Marc Rousseau, Ch. Finck, Ilaria Rinaldi, R. Rescigno, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), PRISME (PRISME), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut Lumière Matière [Villeurbanne] (ILM), Université Claude Bernard Lyon 1 (UCBL), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Ion beam, Dose profile, Heavy Ion Radiotherapy, Bragg peak, Imaging phantom, 030218 nuclear medicine & medical imaging, Ion, 03 medical and health sciences, 0302 clinical medicine, Optics, Humans, Radiology, Nuclear Medicine and imaging, Computer vision, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Physics, Radiological and Ultrasound Technology, Phantoms, Imaging, business.industry, Detector, Radiotherapy Dosage, Radiotherapy, Computer-Assisted, Vertex (geometry), Inflection point, 030220 oncology & carcinogenesis, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Artificial intelligence, Protons, business
Abstract

International audience; Ion beam therapy enables a highly accurate dose conformation delivery to the tumor due to the finite range of charged ions in matter (i.e. Bragg peak (BP)). Consequently, the dose profile is very sensitive to patients anatomical changes as well as minor mispositioning, and so it requires improved dose control techniques. Proton interaction vertex imaging (IVI) could offer an online range control in carbon ion therapy. In this paper, a statistical method was used to study the sensitivity of the IVI technique on experimental data obtained from the Heidelberg Ion-Beam Therapy Center.The vertices of secondary protons were reconstructed with pixelized silicon detectors. The statistical study used the x2 test of the reconstructed vertex distributions for a given displacement of the BP position as a function of the impinging carbon ions. Different phantom configurations were used with or without bone equivalent tissue and air inserts.The inflection points in the fall-off region of the longitudinal vertex distribution were computed using different methods, while the relation with the BP position was established. In the present setup, the resolution of the BP position was about 4–5 mm in the homogeneous phantom under clinical conditions (106 incident carbon ions). Our results show that the IVI method could therefore monitor the BP position with a promising resolution in clinical conditions.

Published
2017

3. Backward compatibility effects in younger and older adults

Author

Patricia J. Krimmer, Alan A. Hartley, Kathryn E. Frazier, François Maquestiaux, and Sara B. Festini

Subjects
Male, Psychological refractory period, Linguistics and Language, Adolescent, Experimental and Cognitive Psychology, Stimulus (physiology), behavioral disciplines and activities, 050105 experimental psychology, Language and Linguistics, Backward compatibility, Bottleneck, Developmental psychology, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Age groups, Task Performance and Analysis, Humans, 0501 psychology and cognitive sciences, Aged, Aged, 80 and over, 05 social sciences, Age Factors, Sensory Systems, Refractory Period, Psychological, Younger adults, Female, Psychology, Psychomotor Performance, psychological phenomena and processes, 030217 neurology & neurosurgery, Cognitive psychology
Abstract

In many dual-task situations, responses to the second of two tasks are slowed when the time between tasks is short. The response-selection bottleneck model of dual-task performance accounts for this phenomenon by assuming that central processing of the second task is blocked by a bottleneck until central processing of Task 1 is complete. This assumption could be called into question if it could be demonstrated that the response to Task 2 affected the central processing of Task 1, a backward response compatibility effect. Such effects are well-established in younger adults. Backward compatibility effects in older (as well as younger) adults were explored in two experiments. The first experiment found clear backward response compatibility effects for younger adults but no evidence of them for older adults. The second experiment explored backward stimulus compatibility and found similar effects in both younger and older adults. Evidence possibly consistent with some pre-bottleneck processing of Task 2 central stages also was found in the second experiment in both age groups. For younger adults, the results provide further evidence falsifying the claim of an immutable response selection bottleneck. For older adults, the evidence suggested that Task 2 affects Task 1 when there is stimulus compatibility but not when there is response compatibility.

Published
2016

4. Prompt-gamma monitoring in hadrontherapy: A review

Author

Denis Dauvergne, Jean Michel Létang, Etienne Testa, J. Krimmer, Rayet, Béatrice, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), PRISME (PRISME), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Léon Bérard [Lyon], Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Nuclear and High Energy Physics, medicine.medical_specialty, medicine.medical_treatment, Prompt-gamma, Particle therapy, [SDV.CAN]Life Sciences [q-bio]/Cancer, Photon energy, Radiation, Collimated light, 030218 nuclear medicine & medical imaging, law.invention, 03 medical and health sciences, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, law, Hadrontherapy, medicine, Electronic engineering, Medical physics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Radiation treatment planning, Instrumentation, Proton therapy, Gamma camera, Physics, [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], business.industry, [PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 030220 oncology & carcinogenesis, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], business, Quality assurance
Abstract

International audience; Secondary radiation emission induced by nuclear reactions is correlated to the path of ions in matter. Therefore, such penetrating radiation can be used for in vivo control of hadrontherapy treatments, for which the primary beam is absorbed inside the patient. Among secondary radiations, prompt-gamma rays were proposed for real-time verification of ion range. Such a verification is a desired condition to reduce uncertainties in treatment planning. For more than a decade, efforts have been undertaken worldwide to promote prompt-gamma-based devices to be used in clinical conditions. Dedicated cameras are necessary to overcome the challenges of a broad- and high-energy distribution, a large background, high instantaneous count rates, and compatibility constraints with patient irradiation. Several types of prompt-gamma imaging devices have been proposed, that are either physically-collimated or electronically collimated (Compton cameras). Clinical tests are now undergoing. Meanwhile, other methods than direct prompt-gamma imaging were proposed, that are based on specific counting using either time-of-flight or photon energy measurements. In the present article, we make a review and discuss the state of the art for all techniques using prompt-gamma detection to improve the quality assurance in hadrontherapy.

Published
2018

5. Technical Note: Experimental carbon ion range verification in inhomogeneous phantoms using prompt gammas

Author

Nicolas Freud, M. Testa, Marco Pinto, Cédric Ray, Denis Dauvergne, M. De Rydt, Jean Michel Létang, Etienne Testa, J. Krimmer, and George Dedes

Subjects
Materials science, business.industry, Monte Carlo method, Collimator, Context (language use), General Medicine, Charged particle, Imaging phantom, 030218 nuclear medicine & medical imaging, Ion, law.invention, 03 medical and health sciences, 0302 clinical medicine, Optics, law, Mockup, 030220 oncology & carcinogenesis, business, Beam (structure)
Abstract

Purpose: The purpose of this study was to experimentally assess the possibility to monitor carbon ion range variations—due to tumor shift and/or elongation or shrinking—using prompt-gamma (PG) emission with inhomogeneous phantoms. Such a study is related to the development of PG monitoring techniques to be used in a carbon ion therapy context. Methods: A 95 MeV/u carbon ion beam was used to irradiate phantoms with a variable density along the ion path to mimic the presence of bone and lung in homogeneous humanlike tissue. PG profiles were obtained after a longitudinal scan of the phantoms. A setup comprising a narrow single-slit collimator and two detectors placed at 90° with respect to the beam axis was used. The time of flight technique was applied to allow the selection between PG and background events. Results: Using the positions at 50% entrance and 50% falloff of the PG profiles, a quantity called prompt-gamma profile length (PGPL) is defined. It is possible to observe shifts in the PGPL when there are absolute ion range shifts as small as 1–2 mm. Quantitatively, for an ion range shift of −1.33 ± 0.46 mm (insertion of a Teflon slab), a PGPL difference of −1.93 ± 0.58 mm and −1.84 ± 1.27 mm is obtained using a BaF2 and a NaI(Tl) detector, respectively. In turn, when an ion range shift of 4.59 ± 0.42 mm (insertion of a lung-equivalent material slab) is considered, the difference is of 4.10 ± 0.54 and 4.39 ± 0.80 mm for the same detectors. Conclusions: Herein, experimental evidence of the usefulness of employing PG to monitor carbon ion range using inhomogeneous phantoms is presented. Considering the homogeneous phantom as reference, the results show that the information provided by the PG emission allows for detecting ion range shifts as small as 1–2 mm. When considering the expected PG emission from an energy slice in a carbon ion therapy scenario, the experimental setup would allow to retrieve the same PGPL as the high statistics of the full experimental dataset in 58% of the times. However, this success rate increases to 93% when using a better optimized setup by means of Monte Carlo simulations.

Published
2015

6. Design optimisation of a TOF-based collimated camera prototype for online hadrontherapy monitoring

Author

J. Krimmer, Marco Pinto, F. Roellinghoff, Cédric Ray, Nicolas Freud, Etienne Testa, Denis Dauvergne, Jean Michel Létang, Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Computer science, medicine.medical_treatment, Physics::Medical Physics, Real-time computing, Monte Carlo method, Online Systems, Collimated light, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Proton Therapy, medicine, Humans, Polymethyl Methacrylate, Radiology, Nuclear Medicine and imaging, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Radiometry, Proton therapy, Image resolution, Simulation, Modality (human–computer interaction), Radiological and Ultrasound Technology, Phantoms, Imaging, Equipment Design, Radiotherapy, Computer-Assisted, Radiation therapy, Gamma Rays, Homogeneous, 030220 oncology & carcinogenesis, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Key (cryptography), Monte Carlo Method
Abstract

International audience; Hadrontherapy is an innovative radiation therapy modality for which one of the main key advantages is the target conformality allowed by the physical properties of ion species. However, in order to maximise the exploitation of its potentialities, online monitoring is required in order to assert the treatment quality, namely monitoring devices relying on the detection of secondary radiations. Herein is presented a method based on Monte Carlo simulations to optimise a multi-slit collimated camera employing time-of-flight selection of prompt-gamma rays to be used in a clinical scenario. In addition, an analytical tool is developed based on the Monte Carlo data to predict the expected precision for a given geometrical configuration. Such a method follows the clinical workflow requirements to simultaneously have a solution that is relatively accurate and fast. Two different camera designs are proposed, considering different endpoints based on the trade-off between camera detection efficiency and spatial resolution to be used in a proton therapy treatment with active dose delivery and assuming a homogeneous target.

Published
2014

7. A cost-effective monitoring technique in particle therapy via uncollimated prompt gamma peak integration

Author

Joel Herault, Marco Pinto, H. Mathez, J. Krimmer, Denis Dauvergne, Jean Michel Létang, Nicolas Freud, G. Angellier, Y. Zoccarato, Etienne Testa, L. Balleyguier, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), PRISME (PRISME), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Unité de Radiothérapie, Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre Antoine Lacassagne de Nice-Centre de Lutte contre le Cancer, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre Léon Bérard [Lyon], Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Imagerie Tomographique et Radiothérapie, Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), Université Côte d'Azur (UCA)-UNICANCER-Université Côte d'Azur (UCA)-UNICANCER-Centre de Lutte contre le Cancer, Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Nice Sophia Antipolis (1965 - 2019) (UNS), UNICANCER-Université Côte d'Azur (UCA)-UNICANCER-Université Côte d'Azur (UCA)-Centre de Lutte contre le Cancer, Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Rayet, Béatrice

Subjects
Physics and Astronomy (miscellaneous), Proton, medicine.medical_treatment, Astrophysics::High Energy Astrophysical Phenomena, Cyclotron, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, Modulators, Position sensitive detectors, 030218 nuclear medicine & medical imaging, law.invention, [SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine, 03 medical and health sciences, 0302 clinical medicine, Optics, law, medicine, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Particle beam detectors, Physics, Range (particle radiation), Particle therapy, [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], business.industry, Detector, Gamma rays, Gamma ray, Solid angle, 3. Good health, Beamline, [PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 030220 oncology & carcinogenesis, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Protons, business
Abstract

International audience; For the purpose of detecting deviations from the prescribed treatment during particle therapy, the integrals of uncollimated prompt gamma-ray timing distributions are investigated. The intention is to provide information, with a simple and cost-effective setup, independent from monitoring devices of the beamline. Measurements have been performed with 65 MeV protons at a clinical cyclotron. Prompt gamma-rays emitted from the target are identified by means of time-of-flight. The proton range inside the PMMA target has been varied via a modulator wheel. The measured variation of the prompt gamma peak integrals as a function of the modulator position is consistent with simulations. With detectors covering a solid angle of 25 msr (corresponding to a diameter of 3–4 in. at a distance of 50 cm from the beam axis) and 108 incident protons, deviations of a few per cent in the prompt gamma-ray count rate can be detected. For the present configuration, this change in the count rate corresponds to a 3 mm change in the proton range in a PMMA target. Furthermore, simulation studies show that a combination of the signals from multiple detectors may be used to detect a misplacement of the target. A different combination of these signals results in a precise number of the detected prompt gamma rays, which is independent on the actual target position.

Published
2017

8. Real-time proton beam range monitoring by means of prompt-gamma detection with a collimated camera

Author

Marco Pinto, Denis Dauvergne, Julien Smeets, Jean Michel Létang, A. Benilov, J. Krimmer, George Dedes, Nicolas Freud, Damien Prieels, Cédric Ray, F. Roellinghoff, Etienne Testa, Frédéric Stichelbaut, Guillaume Janssens, Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Ion Beam Applications SA, IBA, PRISME (PRISME), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Imagerie Tomographique et Radiothérapie, Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon)

Subjects
Proton, Physics::Instrumentation and Detectors, Physics::Medical Physics, Bragg peak, Collimated light, Particle detector, 030218 nuclear medicine & medical imaging, Radiotherapy, High-Energy, 03 medical and health sciences, 0302 clinical medicine, Optics, Computer Systems, Proton Therapy, Radiology, Nuclear Medicine and imaging, Gamma Cameras, Radiometry, Nuclear Experiment, Proton therapy, Physics, Radiological and Ultrasound Technology, business.industry, Detector, Gamma ray, Equipment Design, Radiotherapy, Computer-Assisted, Equipment Failure Analysis, Gamma Rays, 030220 oncology & carcinogenesis, Physics::Accelerator Physics, business, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Beam (structure)
Abstract

International audience; Prompt-gamma profile was measured at WPE-Essen using 160 MeV protons impinging a movable PMMA target. A single collimated detector was used with time-of-flight (TOF) to reduce the background due to neutrons. The target entrance rise and the Bragg peak falloff retrieval precision was determined as a function of incident proton number by a fitting procedure using independent data sets. Assuming improved sensitivity of this camera design by using a greater number of detectors, retrieval precisions of 1 to 2 mm (rms) are expected for a clinical pencil beam. TOF improves the contrast-to-noise ratio and the performance of the method significantly.

Published
2014
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9. Absorbed Energy Monitoring during Hadrontherapy via Prompt Gamma Detection

Author

J. Krimmer, L. Balleyguier, Nicolas Freud, Denis Dauvergne, M. Fontana, Jean Michel Létang, Marco Pinto, Joel Herault, Etienne Testa, H. Mathez, Y. Zoccarato, Charbel Koumeir, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Radiothérapie, Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre Antoine Lacassagne de Nice-Centre de Lutte contre le Cancer, Laboratoire SUBATECH Nantes (SUBATECH), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre Léon Bérard [Lyon], Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), Université Côte d'Azur (UCA)-UNICANCER-Université Côte d'Azur (UCA)-UNICANCER-Centre de Lutte contre le Cancer, and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes)

Subjects
Physics, Scintillation, medicine.medical_specialty, business.industry, Physics::Instrumentation and Detectors, Detector, Gamma ray, Monitoring system, [SDV.CAN]Life Sciences [q-bio]/Cancer, equipment and supplies, 030218 nuclear medicine & medical imaging, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Data acquisition, Optics, Energy absorbing, 030220 oncology & carcinogenesis, medicine, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Medical physics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Gamma detection, business, Beam (structure)
Abstract

International audience; An independent monitoring system aiming for the detection of deviations from the prescribed treatment in hadrontherapy is presented. The system is based on prompt gammaray detection via scintillation detectors and the use of time-offlight information. Test measurements at cyclotrons show the influence of degraders used in passive beam delivery systems. A dedicated data acquisition card has been developed which is suitable to provide timing and energy information from scintillation detectors at counting rates compatible with clinical beam intensities.

Published
2016

10. 38. Comparison between Anger and Compton cameras for medical imaging: A Monte Carlo simulation study

Author

Etienne Testa, Denis Dauvergne, J.M. Létang, J. Krimmer, Voichita Maxim, Mattia Fontana, and J.-L. Ley

Subjects
Astrophysics::High Energy Astrophysical Phenomena, Physics::Medical Physics, Monte Carlo method, Biophysics, General Physics and Astronomy, Single-photon emission computed tomography, Collimated light, 030218 nuclear medicine & medical imaging, law.invention, 03 medical and health sciences, 0302 clinical medicine, Optics, law, Medical imaging, medicine, Radiology, Nuclear Medicine and imaging, Image resolution, Physics, medicine.diagnostic_test, business.industry, Detector, Collimator, General Medicine, 030220 oncology & carcinogenesis, Focus (optics), business
Abstract

Introduction Single Photon Emission Computed Tomography (SPECT) is at present one of the major techniques for non-invasive diagnostics in nuclear medicine. Almost the whole clinical routine is based on collimated cameras, originally proposed by Anger. Due to the presence of mechanical collimation, detection efficiency and energy acceptance are limited and fixed by the system geometrical features. In order to overcome these limitations, the application of Compton cameras for SPECT is being investigated for several years. Methods We propose in this study to compare a commercial SPECT-Anger device, the GE Healthcare Infinia system with HEGP collimator, and the Compton camera prototype under development by our collaboration [1] , through Monte Carlo simulations (GATE v7.1 and Geant4 9.6 respectively). Given the possible introduction of new radio-emitters at higher energies intrinsically allowed by the Compton camera detection principle, the detectors are exposed to point-like sources at increasing primary gamma energies, from actual isotopes already proposed for nuclear medicine applications. The detector performances are studied in terms of radial event distribution, detection efficiency and final image, obtained by gamma transmission analysis for the Anger system, and with an iterative LM-MLEM algorithm for the Compton reconstruction. Results Preliminary results show for the Compton camera a detection efficiency increased of a factor greater than an order of magnitude, associated with an enhanced spatial resolution for energies beyond 500 keV. Conclusion We discuss then the proven advantages of Compton camera application with particular focus on dose delivered to the patient, examination time and spatial uncertainties.

Published
2017

11. Assessment of Geant4 Prompt-Gamma Emission Yields in the Context of Proton Therapy Monitoring

Author

Etienne Testa, J. Krimmer, Marco Pinto, Denis Dauvergne, Jean Michel Létang, Nicolas Freud, Rayet, Béatrice, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL)

Subjects
Cancer Research, medicine.medical_specialty, Proton, medicine.medical_treatment, Astrophysics::High Energy Astrophysical Phenomena, Monte Carlo method, Binary number, Geant4, Context (language use), lcsh:RC254-282, 030218 nuclear medicine & medical imaging, in-beam monitoring, 03 medical and health sciences, 0302 clinical medicine, hadrontherapy, prompt gammas, medicine, proton therapy, Medical physics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Proton therapy, Original Research, Physics, Particle therapy, [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], monte carlo, online monitoring, nuclear fragmentation models, Gamma ray, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Computational physics, particle therapy, Oncology, Cascade, [PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 030220 oncology & carcinogenesis, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], collimated camera
Abstract

International audience; Monte Carlo tools have been long used to assist the research and development of solutions for proton therapy monitoring. The present work focuses on the prompt-gamma emission yields by comparing experimental data with the outcomes of the current version of Geant4 using all applicable proton inelastic models. For the case in study and using the binary cascade model, it was found that Geant4 overestimates the prompt-gamma emission yields by 40.2 ± 0.3%, even though it predicts the prompt-gamma profile length of the experimental profile accurately. In addition, the default implementations of all proton inelastic models show an overestimation in the number of prompt gammas emitted. Finally, a set of built-in options and physically sound Geant4 source code changes have been tested in order to try to improve the discrepancy observed. A satisfactory agreement was found when using the QMD model with a wave packet width equal to 1.3 fm 2 .

Published
2016

12. Design Study of the Absorber Detector of a Compton Camera for On-Line Control in Ion Beam Therapy

Author

M. De Rydt, Nicolas Freud, Voichita Maxim, F. Roellinghoff, M. Dahoumane, Cédric Ray, Denis Dauvergne, Jean Michel Létang, J. Krimmer, Gerard Montarou, X. Lojacono, Etienne Testa, A.H. Walenta, George Dedes, M.-H. Richard, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Imagerie Tomographique et Radiothérapie, Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL)

Subjects
Physics, Nuclear and High Energy Physics, Photon, Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, business.industry, Detector, Compton scattering, Scintillator, 01 natural sciences, Lyso, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Optics, 0302 clinical medicine, Nuclear Energy and Engineering, 030220 oncology & carcinogenesis, 0103 physical sciences, Scintillation counter, Electrical and Electronic Engineering, Image sensor, business, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Image resolution
Abstract

International audience; The goal of this study is to tune the design of the absorber detector of a Compton camera for prompt γ-ray imaging during ion beam therapy. The response of the Compton camera to a photon point source with a realistic energy spectrum (corresponding to the prompt γ-ray spectrum emitted during the carbon irradiation of a water phantom) is studied by means of Geant4 simulations. Our Compton camera consists of a stack of 2 mm thick silicon strip detectors as a scatter detector and of a scintillator plate as an absorber detector. Four scintillators are considered: LYSO, NaI, LaBr3 and BGO. LYSO and BGO appear as the most suitable materials, due to their high photo-electric cross-sections, which leads to a high percentage of fully absorbed photons. Depth-of-interaction measurements are shown to have limited influence on the spatial resolution of the camera. In our case, the thickness which gives the best compromise between a high percentage of photons that are fully absorbed and a low parallax error is about 4 cm for the LYSO detector and 4.5 cm for the BGO detector. The influence of the width of the absorber detector on the spatial resolution is not very pronounced as long as it is lower than 30 cm.

Published
2012
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13. Probabilistic models and numerical calculation of system matrix and sensitivity in list-mode MLEM 3D reconstruction of Compton camera images

Author

Voichita Maxim, E. Hilaire, X. Lojacono, Rémy Prost, Etienne Testa, Denis Dauvergne, J. Krimmer, Isabelle E. Magnin, Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales (MOTIVATE), Images et Modèles, 4 - Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé ( CREATIS ), Hospices Civils de Lyon ( HCL ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Hospices Civils de Lyon ( HCL ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ), Institut de Physique Nucléaire de Lyon ( IPNL ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), and 1 - Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales ( MOTIVATE )

Subjects
Computer science, Monte Carlo method, Iterative reconstruction, Compton camera, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, 01 natural sciences, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Quality (physics), Imaging, Three-Dimensional, 0103 physical sciences, Humans, Radiology, Nuclear Medicine and imaging, Computer vision, Sensitivity (control systems), [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], System matrix, [ PHYS.PHYS.PHYS-INS-DET ] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Models, Statistical, Radiological and Ultrasound Technology, 010308 nuclear & particles physics, business.industry, 3D reconstruction, Probabilistic logic, Radiographic Image Interpretation, Computer-Assisted, Artificial intelligence, business, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
Abstract

International audience; This paper addresses the problem of evaluating the system matrix and the sensitivity for iterative reconstruction in Compton camera imaging. Proposed models and numerical calculation strategies are compared through the influence they have on the three-dimensional reconstructed images. The study attempts to address four questions. First, it proposes an analytic model for the system matrix. Second, it suggests a method for its numerical validation with Monte Carlo simulated data. Third, it compares analytical models of the sensitivity factors with Monte Carlo simulated values. Finally, it shows how the system matrix and the sensitivity calculation strategies influence the quality of the reconstructed images.

Published
2015

14. A large area diamond-based beam tagging hodoscope for ion therapy monitoring

Author

O. Rossetto, Jean-François Muraz, M.-L. Gallin-Martel, L. Abbassi, J.-F. Motte, Ana Lacoste, G. Bosson, R. Vuiart, Denis Dauvergne, F. Rarbi, M. Yamouni, S. Curtoni, John Morse, J. Krimmer, Sara Marcatili, M. Fontana, J. Collot, W. De Nolf, J-Y. Hostachy, L. Gallin-Martel, A. Bes, T. Crozes, Etienne Testa, Murielle Salomé, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Nanofab (Nanofab ), Institut Néel (NEEL), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), European Synchrotron Radiation Facility (ESRF), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
Materials science, SYNTHETIC DIAMOND DETECTORS, Physics::Instrumentation and Detectors, QC1-999, charge collection efficiency, Chemical vapor deposition, engineering.material, 01 natural sciences, CHARGE COLLECTION EFFICIENCY, Particle detector, 030218 nuclear medicine & medical imaging, ON-LINE MONITORING OF HADRON THERAPY, 03 medical and health sciences, 0302 clinical medicine, Optics, Hodoscope, TIME RESOLUTION, 0103 physical sciences, Synthetic diamond detectors, time resolution, 010308 nuclear & particles physics, business.industry, Physics, Detector, Diamond, on-line monitoring of hadron therapy, Bunches, Beamline, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], engineering, Physics::Accelerator Physics, integrated fast read out electronics, business, Beam (structure), INTEGRATED FAST READ OUT ELECTRONICS
Abstract

International audience; The MoniDiam project is part of the French national collaboration CLaRyS (Contrôle en Ligne de l'hAdronthérapie par RaYonnements Secondaires) for on-line monitoring of hadron therapy. It relies on the imaging of nuclear reaction products that is related to the ion range. The goal here is to provide large area beam detectors with a high detection efficiency for carbon or proton beams giving time and position measurement at 100 MHz count rates (beam tagging hodoscope). High radiation hardness and intrinsic electronic properties make diamonds reliable and very fast detectors with a good signal to noise ratio. Commercial Chemical Vapor Deposited (CVD) poly-crystalline, heteroepitaxial and monocrystalline diamonds were studied. Their applicability as a particle detector was investigated using α and β radioactive sources, 95 MeV/u carbon ion beams at GANIL and 8.5 keV X-ray photon bunches from ESRF. This facility offers the unique capability of providing a focused (~1 µm) beam in bunches of 100 ps duration, with an almost uniform energy deposition in the irradiated detector volume, therefore mimicking the interaction of single ions. A signal rise time resolution ranging from 20 to 90 ps rms and an energy resolution of 7 to 9% were measured using diamonds with aluminum disk shaped surface metallization. This enabled us to conclude that polycrystalline CVD diamond detectors are good candidates for our beam tagging hodoscope development. Recently, double-side stripped metallized diamonds were tested using the XBIC (X Rays Beam Induced Current) setup of the ID21 beamline at ESRF which permits us to evaluate the capability of diamond to be used as position sensitive detector. The final detector will consist in a mosaic arrangement of double-side stripped diamond sensors read out by a dedicated fast-integrated electronics of several hundreds of channels. Index Terms— Synthetic diamond detectors, on-line monitoring of hadron therapy, charge collection efficiency, time resolution, integrated fast read out electronics

Published
2018

15. Collimated prompt gamma TOF measurements with multi-slit multi-detector configurations

Author

C. La Tessa, M.-H. Richard, Marco Pinto, J. Krimmer, Etienne Testa, V. Reithinger, Denis Dauvergne, George Dedes, Jean Michel Létang, M. Chevallier, M. De Rydt, Christoph Schuy, Julie Constanzo, Nicolas Freud, Ilaria Rinaldi, R. Pleskac, Cédric Ray, P. Henriquet, F. Roellinghoff, M. Testa, Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biophysics Department [Darmstadt], Helmholtz Centre for Heavy Ion Research (GSI), Heidelberg Ion Beam Therapy Center - HIT, and Heidelberg University Clinic

Subjects
medicine.medical_specialty, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, PET PET/CT, 01 natural sciences, Electromagnetic radiation, Collimated light, 030218 nuclear medicine & medical imaging, law.invention, 03 medical and health sciences, 0302 clinical medicine, Optics, Instrumentation for hadron therapy, law, 0103 physical sciences, medicine, Medical physics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Coronary CT angiography (CTA), Gamma camera, SPECT, Instrumentation, Mathematical Physics, coronary CT angiography (CTA), Physics, 010308 nuclear & particles physics, business.industry, Scattering, Detector, Collimator, Electromagnetic shielding, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Physics::Accelerator Physics, business, Beam (structure)
Abstract

International audience; Longitudinal prompt-gamma ray profiles have been measured with a multi-slit multi-detector configuration at a 75 MeV/u 13C beam and with a PMMA target. Selections in time-of-flight and energy have been applied in order to discriminate prompt-gamma rays produced in the target from background events. The ion ranges which have been extracted from each individual detector module agree amongst each other and are consistent with theoretical expectations. In a separate dedicated experiment with 200 MeV/u 12C ions the fraction of inter-detector scattering has been determined to be on the 10%-level via a combination of experimental results and simulations. At the same experiment different collimator configurations have been tested and the shielding properties of tungsten and lead for prompt-gamma rays have been measured.

Published
2015

16. Development of a Compton camera for medical applications based on silicon strip and scintillation detectors

Author

M. Magne, H. Mathez, J. Krimmer, L. Lestand, Denis Dauvergne, Gerard Montarou, Jean Michel Létang, C. Abellan, J.-L. Ley, M. Dahoumane, B. Joly, D. Lambert, Marco Pinto, X. Chen, C. Morel, V. Reithinger, L. Caponetto, Voichita Maxim, Cédric Ray, Nicolas Freud, J.-P. Cachemiche, Y. Zoccarato, Etienne Testa, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Grenoble Alpes - UFR Langage, lettres et arts du spectacle, information et communication - Dpt Journalisme (UGA UFR LLASIC J), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Physics, Nuclear and High Energy Physics, Scintillation, Silicon, business.industry, Detector, chemistry.chemical_element, STRIPS, Bismuth germanate, 030218 nuclear medicine & medical imaging, law.invention, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Optics, chemistry, Stack (abstract data type), Hodoscope, law, 030220 oncology & carcinogenesis, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], business, Instrumentation, Beam (structure)
Abstract

International audience; A Compton camera is being developed for the purpose of ion-range monitoring during hadrontherapy via the detection of prompt-gamma rays. The system consists of a scintillating fiber beam tagging hodoscope, a stack of double sided silicon strip detectors (90 Â 90 Â 2 mm 3 , 2 Â 64 strips) as scatter detectors, as well as bismuth germanate (BGO) scintillation detectors (38 Â 35 Â 30 mm 3 , 100 blocks) as absorbers. The individual components will be described, together with the status of their characterization.

Published
2015

17. Performance of upstream interaction region detectors for the FIRST experiment at GSI

Author

Valeria Sipala, Vincenzo Patera, A. Sciubba, C. Finck, M. C. Morone, Felice Iazzi, D. M. Rossi, Z. Abou-Haidar, María Isabel Gallardo, Piernicola Oliva, L. Stuttge, A. Boudard, M. Anelli, J. Krimmer, Herbert A. Simon, Marco Durante, Valeria Rosso, J. M. Quesada, R. Introzzi, M. A. Cortés-Giraldo, R. Pleskac, V. Monaco, G.A.P. Cirrone, E. Iarocci, Thomas Aumann, T. T. Bohlen, Francesco Romano, Paola Sala, Flavio Marchetto, A Le F{èvre, A. Paoloni, Nunzio Randazzo, M. A. G. Alvarez, M. Carpinelli, Eleuterio Spiriti, C Sfienti, Bruno Golosio, Yvonne Leifels, A. Bocci, Antonio Brunetti, Giacomo Cuttone, N. Kurz, M. Labalme, Luca Piersanti, M. Rousseau, S. Tropea, H. Younis, C. Agodi, Alessio Sarti, G. Ickert, Christoph Schuy, J. P. Fernández-García, Roberto Sacchi, S. Leray, M. De Napoli, D. Juliani, Giuseppe Battistoni, Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Z., Abou Haidar, C., Agodi, M. A. G., Alvarez, M., Anelli, T., Aumann, G., Battistoni, A., Bocci, T. T., Böhlen, A., Boudard, A., Brunetti, M., Carpinelli, G. A. P., Cirrone, M. A., Cortes Giraldo, G., Cuttone, M., De Napoli, Durante, Marco, J. P., Fernández García, C., Finck, M. I., Gallardo, B., Golosio, E., Iarocci, F., Iazzi, G., Ickert, R., Introzzi, D., Juliani, J., Krimmer, N., Kurz, M., Labalme, Y., Leifel, A., Le F{èvre, S., Leray, F., Marchetto, V., Monaco, M. C., Morone, P., Oliva, A., Paoloni, V., Patera, L., Piersanti, R., Pleskac, J. M., Quesada, N., Randazzo, F., Romano, D., Rossi, V., Rosso, M., Rousseau, R., Sacchi, P., Sala, A., Sarti, C., Schuy, A., Sciubba, C., Sfienti, H., Simon, V., Sipala, E., Spiriti, L., Stuttge, S., Tropea, H., Younis, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Abou Haidar, Z, Agodi, C, Alvarez, M, Anelli, M, Aumann, T, Battistoni, G, Bocci, A, Bohlen, T, Boudard, A, Brunetti, A, Carpinelli, M, Cirrone, G, Cortes Giraldo, M, Cuttone, G, De Napol, I, Durante, M, Fernandez Garcia, J, Finck, C, Gallardo, M, Golosio, B, Iarocci, E, Iazzi, F, Ickert, G, Introzzi, R, Juliani, D, Krimmer, J, Kurz, N, Labalme, M, Leifels, Y, Le Fevre, A, Leray, S, Marchetto, F, Monaco, V, Morone, M, Oliva, P, Paoloni, A, Patera, V, Piersanti, L, Pleskac, R, Quesada, J, Randazzo, N, Romano, F, Rossi, D, Rosso, V, Rousseau, M, Sacchi, R, Sala, P, Sarti, A, Schuy, C, Sciubba, A, Sfienti, C, Simon, H, Sipala, V, Spiriti, E, Stuttge, L, Tropea, S, and Younis, H

Subjects
Wire chambers (MWPC, gas and liquid scintillators), Physics::Instrumentation and Detectors, 29.40.Mc, 29.40.Cs, 29.40.Gx, Electron, FIRST, 7. Clean energy, 01 natural sciences, Wire chambers(MWPC, Thin-gap chambers, drift chambers, drift tubes, proportional, chambers etc), Gaseous detectors, Scintillators, scintillation and light emission processes (solid, Particle tracking detectors (Gaseous detectors), 030218 nuclear medicine & medical imaging, 0302 clinical medicine, chambers etc), Detectors and Experimental Techniques, Nuclear Experiment, Instrumentation, drift tubes, Mathematical Physics, Physics, scintillation and light emission processes (solid, gas and liquid scintillators), Carbon-12, Scintillators, scintillation and light emission processes (solid, gas and liquid scintillators), Charged particle, Wire chambers (MWPC, Thin-gap chambers, drift chambers, drift tubes, proportional chambers etc), proportional chambers etc), proportional chambers etc) Particle tracking detectors (Gaseous detectors) Scintillators, Scintillators, article tracking detectors (Gaseous detectors), gas and liquid scintillators) Gaseous detectors, Wire chambers(MWPC, Thin-gap chambers, drift chambers, scintillation and light emission processes (solid, Scintillator, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Wirechambers(MWPC,Thin-gapchambers,driftchambers,drifttubes,proportional chambers etc), Particle detector, Ion, proportional, Nuclear physics, 03 medical and health sciences, 0103 physical sciences, Gaseous detector, ddc:610, 010306 general physics, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin), Measuring instrument, Physics::Accelerator Physics, Beam (structure), particle tracking detectors (gaseous detectors), scintillators, wire chambers(mwpc, thin-gap chambers, wire chambers (mwpc, gaseous detectors
Abstract

Open Access.-- et al., The FIRST (Fragmentation of Ions Relevant for Space and Therapy) experiment at GSI has been designed to study carbon fragmentation, measuring 12C double differential cross sections (∂2σ/∂θ∂E) for different beam energies between 100 and 1000 MeV/u. The experimental setup integrates newly designed detectors in the, so called, Interaction Region around the graphite target. The Interaction Region upstream detectors are a 250 μm thick scintillator and a drift chamber optimized for a precise measurement of the ions interaction time and position on the target. In this article we review the design of the upstream detectors along with the preliminary results of the data taking performed on August 2011 with 400 MeV/u fully stripped carbon ion beam at GSI. Detectors performances will be reviewed and compared to those obtained during preliminary tests, performed with 500 MeV electrons (at the BTF facility in the INFN Frascati Laboratories) and 80 MeV/u protons and carbon ions (at the INFN LNS Laboratories in Catania)., This work has been supported by the European Community FP7 - Capacities, contract ENSAR nº 262010. This work was also supported by Junta de Andalucia and the Spanish Ministerio de Ciencia e Innovacion Contracts P07-FQM-02894, FIS2008-04189 and FPA2008-04972-C03.

Published
2012

18. Assessment and improvements of Geant4 hadronic models in the context of prompt-gamma hadrontherapy monitoring

Author

J. Krimmer, Marco Pinto, Denis Dauvergne, Jean Michel Létang, Etienne Testa, Nicolas Freud, Cédric Ray, George Dedes, Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Department of Medical Physics, Ludwig-Maximilians-Universität München (LMU), Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics, Nuclear reaction, Range (particle radiation), Radiological and Ultrasound Technology, Proton, Radiotherapy, 010308 nuclear & particles physics, Monte Carlo method, Hadron, Nuclear Theory, Context (language use), 01 natural sciences, Charged particle, 030218 nuclear medicine & medical imaging, Nuclear physics, 03 medical and health sciences, 0302 clinical medicine, Gamma Rays, 0103 physical sciences, Humans, Radiology, Nuclear Medicine and imaging, Neutron, Nuclear Experiment, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Monte Carlo Method
Abstract

International audience; Monte Carlo simulations are nowadays essential tools for a wide range of research topics in the field of radiotherapy. They also play an important role in the effort to develop a real-time monitoring system for quality assurance in proton and carbon ion therapy, by means of prompt-gamma detection. The internal theoretical nuclear models of Monte Carlo simulation toolkits are of decisive importance for the accurate description of neutral or charged particle emission, produced by nuclear interactions between beam particles and target nuclei. We assess the performance of Geant4 nuclear models in the context of prompt-gamma emission, comparing them with experimental data from proton and carbon ion beams. As has been shown in the past and further indicated in our study, the prompt-gamma yields are consistently overestimated by Geant4 by a factor of about 100% to 200% over an energy range from 80 to 310 MeV/u for the case of 12C, and to a lesser extent for 160 MeV protons. Furthermore, we focus on the quantum molecular dynamics (QMD) modeling of ion-ion collisions, in order to optimize its description of light nuclei, which are abundant in the human body and mainly anticipated in hadrontherapy applications. The optimization has been performed by benchmarking QMD free parameters with well established nuclear properties. In addition, we study the effect of this optimization on charged particle emission. With the usage of the proposed parameter values, discrepancies reduce to less than 70%, with the highest values being attributed to the nucleon-ion induced prompt-gammas. This conclusion, also confirmed by the disagreement we observe in the case of proton beams, indicates the need for further investigation on nuclear models which describe proton and neutron induced nuclear reactions.

Published
2014

19. Real-time online monitoring of the ion range by means of prompt secondary radiations

Author

J.-L. Ley, M. Chabot, Ilaria Rinaldi, M. Magne, Joel Herault, C. La Tessa, M. Dahoumane, Damien Prieels, H. Mathez, L. Lestand, M. De Rydt, Stephan Brons, V. Reithinger, L. Caponetto, C. Insa, L. Balleyguier, Voichita Maxim, D. Lambert, Baptiste Joly, Marco Pinto, J. Krimmer, R. Della Negra, R. Pleskac, Denis Dauvergne, George Dedes, Marc Winter, Jean Michel Létang, Gerard Montarou, Katia Parodi, Rémy Prost, P. Force, S. Deng, Julien Smeets, Nicolas Freud, J. Baudot, Y. Zoccarato, X. Lojacono, Etienne Testa, M. Vanstalle, M. H. Richard, Cédric Ray, F. Roellinghoff, X. Chen, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Heidelberg Ion Beam Therapy Center - HIT, Heidelberg University Clinic, Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Cyclotron Biomédical, Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UCA)-UNICANCER-Université Côte d'Azur (UCA), Biophysics Department [Darmstadt], Helmholtz Centre for Heavy Ion Research (GSI), Radiation Therapy and Radiation Oncology, University clinic Heidelberg, Ion Beam Applications SA, IBA, Images et Modèles, Rayet, Béatrice, Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Physics, Range (particle radiation), medicine.medical_specialty, [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [PHYS.NEXP] Physics [physics]/Nuclear Experiment [nucl-ex], 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, Physics::Medical Physics, Detector, Gamma ray, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, 3. Good health, 030218 nuclear medicine & medical imaging, Ion, Nuclear physics, 03 medical and health sciences, 0302 clinical medicine, 0103 physical sciences, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], medicine, Dosimetry, Medical physics, Gamma ray detection
Abstract

International audience; Prompt secondary radiations such as gamma rays and protons can be used for ion-range monitoring during ion therapy either on an energy-slice basis or on a pencil-beam basis. We present a review of the ongoing activities in terms of detector developments, imaging, experimental and theoretical physics issues concerning the correlation between the physical dose and hadronic processes

Published
2013

20. Monte Carlo Nuclear Models Evaluation and Improvements for Real-Time Prompt Gamma-Ray Monitoring in Proton and Carbon Therapy

Author

Cédric Ray, Nicolas Freud, J. Krimmer, George Dedes, Denis Dauvergne, Marco Pinto, Jean Michel Létang, Marieke De Rydt, Etienne Testa, Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Imagerie Tomographique et Radiothérapie, Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), CAS-PHABIO, and Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL)

Subjects
Physics, Range (particle radiation), Proton, Ion beam, 010308 nuclear & particles physics, Nuclear Theory, Monte Carlo method, Gamma ray, chemistry.chemical_element, 01 natural sciences, 7. Clean energy, 030218 nuclear medicine & medical imaging, Nuclear physics, 03 medical and health sciences, 0302 clinical medicine, chemistry, Cascade, 0103 physical sciences, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Physics::Accelerator Physics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Nuclear Experiment, Carbon, Free parameter
Abstract

Accurate Monte Carlo simulations are essential both for the development of an optimized detection array that will be used in clinical practice for precise ion beam range monitoring. Within GEANT4, both the Quantum Molecular Dynamics (QMD) and the Binary Cascade (BIC) models overestimate the overall prompt-gamma depth profile yields measured with carbon ion and proton beams. By optimizing the selection of free parameters of the models, better agreement with the data is obtained for low energy carbon beams (main gamma component by ion-ion collisions) as well as for proton beams and high energy carbon beams (main gamma component by nucleon-nucleus collisions).

Published
2012

21. Electron density resolution determination and systematic uncertainties in proton computed tomography (pCT)

Author

J. Krimmer, Simon Rit, Etienne Testa, Nicolas Freud, Marieke De Rydt, Denis Dauvergne, Jean Michel Létang, Cédric Ray, George Dedes, Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Léon Bérard [Lyon], Instituut voor Kern- en Stralingsfysica, and Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven)

Subjects
Physics, Scanner, medicine.medical_specialty, Range (particle radiation), Electron density, Proton, Quantitative Biology::Tissues and Organs, Physics::Medical Physics, Resolution (electron density), Monte Carlo method, 030218 nuclear medicine & medical imaging, 3. Good health, Computational physics, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, medicine, Physics::Accelerator Physics, Medical physics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Nuclear Experiment, Proton therapy, Beam (structure)
Abstract

International audience; The use of protons in radiotherapy offers a very precise and effective tool for malignant tumor treatment. In order to fully exploit the benefits of proton therapy, a precise determination of the proton range inside the patient is needed. Currently, this information is provided by conventional X-ray CT. In our work, we explore the theoretical limits of proton CT by means of Monte Carlo simulations. We focus on the accuracy in determining the electron density of different clinical relevant materials and the systematic uncertainties that influence the measurement with an ideal cone beam proton CT scanner.

Published
2012

22. 235 REAL-TIME PROTON BEAM RANGE MONITORING BY MEANS OF PROMPT-GAMMA DETECTION WITH A COLLIMATED CAMERA

Author

Nicolas Freud, Cédric Ray, E. Testa, F. Roellinghoff, J. Krimmer, A. Benilov, Frédéric Stichelbaut, Julien Smeets, Denis Dauvergne, Jean Michel Létang, Georgios Dedes, M.-H. Richard, D. Prieels, Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ion Beam Applications SA, IBA, Imagerie Tomographique et Radiothérapie, and Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon)

Subjects
Range (particle radiation), Materials science, Proton, business.industry, Hematology, Collimated light, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Optics, Oncology, 030220 oncology & carcinogenesis, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Radiology, Nuclear Medicine and imaging, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], business, Gamma detection, Beam (structure), ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

23. FIRST experiment: Fragmentation of Ions Relevant for Space and Therapy

Author

Eleuterio Spiriti, A. Foti, M. C. Morone, E. Iarocci, M. Bondì, G. Ickert, G.A.P. Cirrone, Ch. Finck, Andrea Lavagno, Francesco Romano, D. Juliani, C. Agodi, María Isabel Gallardo, J. Krimmer, Giuseppe Battistoni, Felice Iazzi, R. Introzzi, Giacomo Cuttone, Valeria Rosso, J. M. Quesada, Paola Sala, T. T. Bohlen, M. A. Cortés-Giraldo, Piernicola Oliva, Valeria Sipala, M. De Napoli, V. Monaco, A. Le Fèvre, D. Nicolosi, Roberto Sacchi, Nunzio Randazzo, Thomas Aumann, M Cavallaro, R. Pleskac, Bruno Golosio, Francesco Cappuzzello, M. A. G. Alvarez, S. Leray, N. Kurz, Z. Abou-Haidar, Concettina Sfienti, Alessio Sarti, A. Bocci, J. P. Fernández-García, Luca Piersanti, M. Rousseau, S. Tropea, Flavio Marchetto, Herbert A. Simon, Antonio Brunetti, Yvonne Leifels, A. Boudard, A. Paoloni, Marco Durante, M. Carpinelli, C. Scheidenberger, Christoph Schuy, F. Balestra, M Labalme, L. Stuttge, Vincenzo Patera, Daniele Carbone, A. Sciubba, H. Younis, D. M. Rossi, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Agodi, C, Abou Haidar, Z, Alvarez, M, Aumann, T, Balestra, F, Battistoni, G, Bocci, A, Bohlen, T, Bondi, M, Boudard, A, Brunetti, A, Carpinelli, M, Cappuzzello, F, Cavallaro, M, Carbone, D, Cirrone, G, Cortes Giraldo, M, Cuttone, G, De Napoli, M, Durante, M, Fernandez Garcia, J, Finck, C, Foti, A, Gallardo, M, Golosio, B, Iarocci, E, Iazzi, F, Ickert, G, Introzzi, R, Juliani, D, Krimmer, J, Kurz, N, Labalme, M, Lavagno, A, Leifels, Y, Le Fevre, A, Leray, S, Marchetto, F, Monaco, V, Morone, M, Nicolosi, D, Oliva, P, Paoloni, A, Patera, V, Piersanti, L, Pleskac, R, Quesada, J, Randazzo, N, Romano, F, Rossi, D, Rosso, V, Rousseau, M, Sacchi, R, Sala, P, Sarti, A, Scheidenberger, C, Schuy, C, Sciubba, A, Sfienti, C, Simon, H, Sipala, V, Spiriti, E, Stuttge, L, Tropea, S, Younis, H, Agodi, C., Abou-Haidar, Z., Alvarez, M. A. G., Aumann, T., Balestra, F., Battistoni, G., Bocci, A., Bohlen, T. T., Bondi, M., Boudard, A., Brunetti, A., Carpinelli, M., Cappuzzello, F., Cavallaro, M., Carbone, D., Cirrone, G. A. P., Cortes-Giraldo, M. A., Cuttone, G., Napoli, M. D., Durante, M., Fernandez-Garcia, J. P., Finck, C., Foti, A., Gallardo, M. I., Golosio, B., Iarocci, E., Iazzi, F., Ickert, G., Introzzi, R., Juliani, D., Krimmer, J., Kurz, N., Labalme, M., Lavagno, A., Leifels, Y., Fevre, A. L., Leray, S., Marchetto, F., Monaco, V., Morone, M. C., Nicolosi, D., Oliva, P., Paoloni, A., Patera, V., Piersanti, L., Pleskac, R., Quesada, J. M., Randazzo, N., Romano, F., Rossi, D., Rosso, V., Rousseau, M., Sacchi, R., Sala, P., Sarti, A., Scheidenberger, C., Schuy, C., Sciubba, A., Sfienti, C., Simon, H., Sipala, V., Spiriti, E., Stuttge, L., Tropea, S., and Younis, H.

Subjects
History, Silicon detector, Applied physics, Physics::Instrumentation and Detectors, Scintillator, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 7. Clean energy, 01 natural sciences, Space radiation, 030218 nuclear medicine & medical imaging, Education, Ion, Experimental apparatu, Nuclear physics, 03 medical and health sciences, Physics and Astronomy (all), 0302 clinical medicine, Fragmentation (mass spectrometry), 0103 physical sciences, Neutron detection, ddc:530, Silicon Vertex Detector, 010306 general physics, Nuclear Experiment, Scintillation counter, Radiation protection, Physics, Detector, Nuclear fragmentation, Computer Science Applications, International collaboration, Protection application, Magnet, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Scientific program, International cooperation, Nucleon, Interaction region
Abstract

International audience; Nuclear fragmentation processes are relevant in different fields of basic research and applied physics and are of particular interest for tumor therapy and for space radiation protection applications. The FIRST (Fragmentation of Ions Relevant for Space and Therapy) experiment at SIS accelerator of GSI laboratory in Darmstadt, has been designed for the measurement of different ions fragmentation cross sections at different energies between 100 and 1000 MeV/nucleon. The experiment is performed by an international collaboration made of institutions from Germany, France, Italy and Spain. The experimental apparatus is partly based on an already existing setup made of the ALADIN magnet, the MUSIC IV TPC, the LAND2 neutron detector and the TOFWALL scintillator TOF system, integrated with newly designed detectors in the interaction Region (IR) around the carbon removable target: a scintillator Start Counter, a Beam Monitor drift chamber, a silicon Vertex Detector and a Proton Tagger for detection of light fragments emitted at large angles (KENTROS). The scientific program of the FIRST experiment started on summer 2011 with the study of the 400 MeV/nucleon 12C beam fragmentation on thin (8mm) carbon target.

Published
2012

24. The FIRST experiment for nuclear fragmentation measurements at GSI

Author

C. Agodi, N. Kurz, M. Rousseau, Alessio Sarti, A. Bocci, S. Leray, D. Juliani, Giuseppe Battistoni, M. Carpinelli, L. Stuttge, M. C. Morone, H. Simon, T. T. Bohlen, F. Iazzi, Luciano Piersanti, Piernicola Oliva, C. Scheidenberger, R. Introzzi, M. A. Cortés-Giraldo, R. Pleskac, I. Leifels, Z. Abou-Haidar, Flavio Marchetto, C. Sfienti, C. Finck, S. Tropea, Marco Durante, Paola Sala, J. M. Quesada, Vincenzo Patera, M. Labalme, M. De Napoli, R. Sacchi, Nunzio Randazzo, Bruno Golosio, Eleuterio Spiriti, M. A. G. Alvarez, Dario Rossi, J. Krimmer, G. Ickert, V. Monaco, Giacomo Cuttone, Christoph Schuy, A. Le Fèvre, Valeria Sipala, Thomas Aumann, A. Boudard, E. Iarocci, Francesco Romano, G.A.P. Cirrone, Giovanni Luca Masala, A. Paoloni, Antonio Brunetti, Adalberto Sciubba, Y. Hannan, Golosio, B, Abou Haidar, Z, Agodi, C, Alvarez, M, Aumann, T, Battistoni, G, Bocci, A, Böhlen, T, Boudard, A, Brunetti, A, Carpinelli, M, Cirrone, G, Cortes Giraldo, M, Cuttone, G, De Napoli, M, Durante, M, Finck, C, Hannan, Y, Iarocci, E, Iazzi, F, Ickert, G, Introzzi, R, Juliani, D, Krimmer, J, Kurz, N, Labalme, M, Leifels, I, Le Fevre, A, Leray, S, Marchetto, F, Masala, G, Monaco, V, Morone, M, Oliva, P, Paoloni, A, Patera, V, Piersanti, L, Pleskac, R, Quesada, J, Randazzo, N, Romano, F, Rossi, D, Rousseau, M, Sacchi, R, Sala, P, Sarti, A, Scheidenberger, C, Schuy, C, Sciubba, A, Sfienti, C, Simon, H, Sipala, V, Spiriti, E, Stuttge, L, Tropea, S, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), and Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
Nuclear and High Energy Physics, Energy ranges, Double differential cross sections, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Double differential cross section, Kinetic energy, 01 natural sciences, 7. Clean energy, 030218 nuclear medicine & medical imaging, Ion, Nuclear physics, 03 medical and health sciences, Hadron therapy, 0302 clinical medicine, Data acquisition, Fragmentation (mass spectrometry), Basic research, Nuclear Medicine and Imaging, Germany, 0103 physical sciences, Nuclear Experiment, Gold target, Physics, Experimental apparatus, Radiation, 010308 nuclear & particles physics, Scattering, Nuclear fragmentation, Space radiation, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin), Polar angles, Protection application, Space radiations, Radiology, Nuclear Medicine and Imaging, Radiology
Abstract

International audience; Nuclear fragmentation processes are relevant in different fields of physics concerning both basic research and applications. FIRST (Fragmentation of Ions Relevant for Space and Therapy) is an experiment aimed at the measurement of double differential cross sections (DDCS), with respect to kinetic energy and scattering polar angle, of nuclear fragmentation processes relevant for hadron therapy and for space radiation protection applications, in the energy range between 100 and 1000 MeV/u. The experiment was mounted at the GSI laboratories of Darmstadt, in Germany. A first data taking was performed in August 2011, using 400 MeV/u 12C on carbon and gold targets. In this work we present a description of the experimental apparatus and some figures from the data acquisition and from the preliminary work on data analysis.

Published
2012

25. 148 REAL-TIME PROMPT GAMMA RAY MONITORING FOR PROTON AND CARBON THERAPY: MONTE CARLO NUCLEAR MODELS EVALUATION AND IMPROVEMENTS

Author

Cédric Ray, Marco Pinto, Marius Chevallier, J. Krimmer, Denis Dauvergne, E. Testa, V. Reithinger, Jean Michel Létang, M. De Rydt, Georgios Dedes, M.-H. Richard, Nicolas Freud, and F. Roellinghoff

Subjects
Carbon therapy, Materials science, Proton, business.industry, Monte Carlo method, Gamma ray, Hematology, 030218 nuclear medicine & medical imaging, Nuclear physics, 03 medical and health sciences, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Radiology, Nuclear Medicine and imaging, Nuclear medicine, business
Published
2012

26. 240 SPATIAL CORRELATIONS BETWEEN IMAGES DERIVED FROM DYNAMIC FDG-PET

Author

Nicolas Freud, Denis Dauvergne, Jean Michel Létang, Cédric Ray, J. Krimmer, P. Henriquet, Georgios Dedes, M.-H. Richard, E. Testa, M. De Rydt, V. Reithinger, and Michel Chevallier

Subjects
03 medical and health sciences, 0302 clinical medicine, Oncology, business.industry, 030220 oncology & carcinogenesis, Radiology, Nuclear Medicine and imaging, Hematology, Nuclear medicine, business, 030218 nuclear medicine & medical imaging
Published
2012

27. 136 REAL-TIME MONITORING OF THE BRAGG PEAK DURING ION THERAPY: RECENT DEVELOPMENTS OF THE BEAM DETECTION SYSTEM

Author

Denis Dauvergne, Jean Michel Létang, Etienne Testa, M. De Rydt, Y. Zoccaratto, V. Reithinger, S. Deng, F. Roellinghoff, Georgios Dedes, M.-H. Richard, Marco Pinto, M. Chevallier, J. Krimmer, H. Mattez, Nicolas Freud, and Cédric Ray

Subjects
Materials science, business.industry, Bragg peak, Hematology, 030218 nuclear medicine & medical imaging, Ion, 03 medical and health sciences, 0302 clinical medicine, Optics, Oncology, 030220 oncology & carcinogenesis, Radiology, Nuclear Medicine and imaging, business, Beam (structure)
Published
2012

28. Simulation toolkit with CMOS detector in the framework of hadrontherapy

Author

J. Krimmer, D. Juliani, Etienne Testa, J. Baudot, Marc Rousseau, Ch. Finck, R. Rescigno, G. Dedes, Denis Dauvergne, Marc Winter, V. Reithinger, Cédric Ray, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
Physics, CMOS sensor, 010308 nuclear & particles physics, business.industry, QC1-999, Detector, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Reconstruction algorithm, Tracking system, 01 natural sciences, 030218 nuclear medicine & medical imaging, Ion, 03 medical and health sciences, 0302 clinical medicine, CMOS, 0103 physical sciences, Carbon ion therapy, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Hardware_INTEGRATEDCIRCUITS, Proton imaging, Electronic engineering, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], business
Abstract

International audience; Proton imaging can be seen as a powerful technique for on-line monitoring of ion range during carbon ion therapy irradiation. The protons detection technique uses, as three-dimensional tracking system, a set of CMOS sensor planes. A simulation toolkit based on GEANT4 and ROOT is presented including detector response and reconstruction algorithm.

Published
2014

29. Interaction vertex imaging (IVI) for carbon ion therapy monitoring: a feasibility study

Author

Marius Chevallier, Cédric Ray, M.-H. Richard, Nicolas Freud, George Dedes, Fabio Sauli, J. Krimmer, Denis Dauvergne, Jean Michel Létang, P. Henriquet, Etienne Testa, Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), CAS-PHABIO, Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL)

Subjects
Nuclear reaction, Diagnostic Imaging, Proton, Physics::Medical Physics, Bragg peak, 7. Clean energy, Coincidence, 030218 nuclear medicine & medical imaging, Ion, 03 medical and health sciences, 0302 clinical medicine, Nuclear magnetic resonance, Hodoscope, Radiology, Nuclear Medicine and imaging, Nuclear Experiment, Physics, Radiological and Ultrasound Technology, Radiotherapy, Uncertainty, Carbon, Computational physics, Vertex (geometry), 030220 oncology & carcinogenesis, Carbon ion therapy, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Physics::Accelerator Physics, Feasibility Studies, Protons
Abstract

Proton imaging can be seen as a powerful technique for online monitoring of ion range during carbon ion therapy irradiations. Indeed, a large number of secondary protons are created during nuclear reactions, and many of these protons are likely to escape from the patient even for deep-seated tumors, carrying accurate information on the reaction vertex position. Two detection techniques have been considered: (i) double-proton detection by means of two forward-located trackers and (ii) single-proton detection in coincidence with the incoming carbon ion detected by means of a beam hodoscope. Geant4 simulations, validated by proton yield measurements performed at GANIL and GSI, show that ion-range monitoring is accessible on a pencil-beam basis with the single-proton imaging technique. Millimetric precision on the Bragg peak position is expected in the ideal case of homogeneous targets. The uncertainties in more realistic conditions should be investigated, in particular the influence of tissue heterogeneity in the very last part of the ion path (about 20 mm).

30. Prompt-Gamma Monitoring of Proton-and Carbon-Therapy. Combined Development of Time-of-Flight Collimated- and Compton-Cameras

Author

J. Krimmer, E. Testa, Nicolas Freud, Denis Dauvergne, and Jean Michel Létang

Subjects
Physics, Carbon therapy, Range (particle radiation), Proton, 010308 nuclear & particles physics, business.industry, Astrophysics::High Energy Astrophysical Phenomena, Physics::Medical Physics, General Physics and Astronomy, 01 natural sciences, Collimated light, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Time of flight, 0302 clinical medicine, Optics, 0103 physical sciences, Millimeter, business, Pencil-beam scanning
Abstract

Prompt-gamma imaging during ion therapy has proven its ability to control the ion range in real time. The achievable precision is of the order of the millimeter for a single spot in proton pencil beam scanning. Collimated gamma cameras have been developed, that are close to clinical application. The Compton cameras are also under development in various laboratories. Time of flight enables the reduction of the background due to other prompt radiations.

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