101. Molecular targeted agents for gastric and gastroesophageal junction cancer.
- Author
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Oshima, Takashi and Masuda, Munetaka
- Subjects
STOMACH cancer ,ESOPHAGOGASTRIC junction cancer ,CANCER cell proliferation ,METASTASIS ,EPIDERMAL growth factor receptors ,VASCULAR endothelial growth factors ,FIBROBLAST growth factors - Abstract
Despite recent improvements in surgical techniques and chemotherapy, advanced cancers of the stomach and gastroesophageal junction (GEJ) continue to have poor clinical outcomes. However, molecules intimately related to cancer cell proliferation, invasion, and metastasis have been studied as candidates for molecular targeted agents. Target molecules, such as the epidermal growth factor receptor, vascular endothelial growth factor receptor, and P13k/Akt/mTor pathway, as well as the insulin-like growth factor receptor, c-Met pathways, fibroblast growth factor receptor, and other pathways are considered to be promising candidates for molecular targeted therapy for gastric and GEJ cancer. In this review we focus on the recent developments in targeting relevant pathways in these types of cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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