1. A new flavonol derivative and other compounds from the leaves of Bauhinia thonningii Schum with activity against multidrug-resistant bacteria.
- Author
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Nouemsi, Guy Raphael Sado, Jouda, Jean-Bosco, Leutcha, Peron Bosco, Matieta, Valaire Yemene, Tsague Tankeu, Virginie Flaure, Ngnouzouba Kuete, Jenifer Reine, Çelik, İlhami, Kuete, Victor, Sewald, Norbert, and Lannang, Alain Meli
- Subjects
FLAVONOLS ,BAUHINIA ,METHICILLIN-resistant staphylococcus aureus ,GRAM-negative bacteria ,BACTERIA ,ANTIBACTERIAL agents ,GRAM-positive bacteria ,MICROCOCCACEAE - Abstract
Investigation of the leaves of Bauhinia thonningii Schum led to the isolation and identification of a new flavonol derivative, 6-C-methylquercetin-3,4'-dimethyl ether (1) together with eleven known compounds (2–13), with two of them (10 and 11) obtained as a mixture. Their structures were established by extensive spectroscopic analyses. Antibacterial activity of compound 1 as well as the reference antibiotic, ciprofloxacin was tested on Gram-negative multidrug-resistant bacteria overexpressing active efflux pumps, and against methicillin-resistant strains of Staphylococcus aureus (MRSA). Samples were tested alone and in combination with an efflux pump inhibitor (EPI), phenylalanine-arginine-β-naphthylamide (PAßN). Results show that when compound 1 was tested alone, its inhibitory effects were obtained on 7/10 tested bacteria with the highest MIC value of 128 µg/mL whilst in the presence of EPI, this activity significantly increase in all the 10 bacteria. An interesting antibacterial activity was obtained with compound 1 against Klebsiella pneumoniae ATCC11296 (MIC of 4 µg/mL), KP55 and Staphylococcus aureus MRSA6 in the presence of the PaßN. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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