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Secondary metabolites from the stem bark of Stereospermum acuminatissimum and their antimicrobial activity.
- Source :
-
Biochemical Systematics & Ecology . Aug2023, Vol. 109, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- Phytochemical investigation of the stem bark of Stereospermum acuminatissimum resulted in the isolation of seventeen compounds, including four tirucallanes (1 – 4), three hopanes (5 – 7), one oleanane (8), three sterols (9 – 11), three saponins (12 – 14), two cinnamic acids (15 – 16), and one iridoid (17). The dehydration of compound 5 led to compound 5a. The structures of all compounds were elucidated by analysis of spectroscopic and mass spectrometric data. Compounds 1 , 6 and 7 are reported from the Bignoniaceae family for the first time, while compounds 11 – 14 and 16 are reported from S. acuminatissimum for the first time. The in vitro antibacterial activities of some compounds (1 – 5 , 8 , 5a), the crude extract and the ethyl acetate fraction were assessed. The crude extract showed significant antibacterial activity against Staphylococcus aureus , Salmonea pneumonia and Klebsiella pneumoniae with MIC values of 62 μg/mL. Compound 1 revealed moderate antibacterial activities against K. pneumoniae , Shigella flexneri and Methycillin resistant S. aureus with MIC values of 62, 62 and 31 μg/mL respectively. [Display omitted] • Phytochemical investigation of Stereospermum acuminatissimum K. Schum. • Dehydration of one of the isolated compound. • Chemophenetic significance of the isolated compounds. • Antibacterial activities of crude extract, fractions and compounds. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03051978
- Volume :
- 109
- Database :
- Academic Search Index
- Journal :
- Biochemical Systematics & Ecology
- Publication Type :
- Academic Journal
- Accession number :
- 164867203
- Full Text :
- https://doi.org/10.1016/j.bse.2023.104648