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A new flavonol derivative and other compounds from the leaves of Bauhinia thonningii Schum with activity against multidrug-resistant bacteria.
- Source :
- Natural Product Research; Aug/Sep2023, Vol. 37 Issue 16, p2653-2661, 9p
- Publication Year :
- 2023
-
Abstract
- Investigation of the leaves of Bauhinia thonningii Schum led to the isolation and identification of a new flavonol derivative, 6-C-methylquercetin-3,4'-dimethyl ether (1) together with eleven known compounds (2–13), with two of them (10 and 11) obtained as a mixture. Their structures were established by extensive spectroscopic analyses. Antibacterial activity of compound 1 as well as the reference antibiotic, ciprofloxacin was tested on Gram-negative multidrug-resistant bacteria overexpressing active efflux pumps, and against methicillin-resistant strains of Staphylococcus aureus (MRSA). Samples were tested alone and in combination with an efflux pump inhibitor (EPI), phenylalanine-arginine-β-naphthylamide (PAßN). Results show that when compound 1 was tested alone, its inhibitory effects were obtained on 7/10 tested bacteria with the highest MIC value of 128 µg/mL whilst in the presence of EPI, this activity significantly increase in all the 10 bacteria. An interesting antibacterial activity was obtained with compound 1 against Klebsiella pneumoniae ATCC11296 (MIC of 4 µg/mL), KP55 and Staphylococcus aureus MRSA6 in the presence of the PaßN. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 37
- Issue :
- 16
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 167303472
- Full Text :
- https://doi.org/10.1080/14786419.2022.2128347