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6 results on '"cembranolides"'

1. Chloro-Furanocembranolides from Leptogorgia sp. Improve Pancreatic Beta-Cell Proliferation.

Author

Gallardo, Amalia B., Díaz-Marrero, Ana R., de la Rosa, José M., D’Croz, Luis, Perdomo, Germán, Cózar-Castellano, Irene, Darias, José, and Cueto, Mercedes

Abstract

Two new chloro-furanocembranolides (1, 2) and two new 1,4-diketo cembranolides (3, 4) were isolated from the crude extract of Leptogorgia sp. together with a new seco-furanocembranolide (5) and the known Z-deoxypukalide (6), rubifolide (7), scabrolide D (8) and epoxylophodione (9). Their structures were determined based on spectroscopic evidence. Four compounds: 1, 2, 7 and 8 were found to activate the proliferation of pancreatic insulin-producing (beta) cells. [ABSTRACT FROM AUTHOR]

Published
2018
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2. New Cytotoxic Cembranolides from the Soft Coral Lobophytum michaelae

Author

Chang-Yih Duh and Shang-Kwei Wang

Subjects
Lobophytum michaelae, cembranolides, cytotoxicity, Biology (General), QH301-705.5
Abstract

Six new cembranolides, michaolides L–Q (1–6), and a known cembranolide, lobomichaolide (7) were isolated from the CH2Cl2 extract of the soft coral Lobophytum michaelae. Their structures were established by extensive spectral analysis. The anti-HCMV (human cytomegalovirus) activity of 1–7 and their cytotoxicity against selected cell lines were evaluated.

Published
2012
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3. Chloro-Furanocembranolides from Leptogorgia sp. Improve Pancreatic Beta-Cell Proliferation

Author

Amalia B. Gallardo, Ana R. Díaz-Marrero, José M. de la Rosa, Luis D’Croz, Germán Perdomo, Irene Cózar-Castellano, José Darias, and Mercedes Cueto

Subjects
Leptogorgia, cembranolides, furanocembranolides, diketocembranolides, seco-furanocembranolides, chloro-furanocembranolides, pancreatic beta-cells, Biology (General), QH301-705.5
Abstract

Two new chloro-furanocembranolides (1, 2) and two new 1,4-diketo cembranolides (3, 4) were isolated from the crude extract of Leptogorgia sp. together with a new seco-furanocembranolide (5) and the known Z-deoxypukalide (6), rubifolide (7), scabrolide D (8) and epoxylophodione (9). Their structures were determined based on spectroscopic evidence. Four compounds: 1, 2, 7 and 8 were found to activate the proliferation of pancreatic insulin-producing (beta) cells.

Published
2018
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4. New Cytotoxic Cembranolides from the Soft Coral Lobophytum michaelae.

Author

Shang-Kwei Wang and Chang-Yih Duh

Abstract

Six new cembranolides, michaolides L-Q (1-6), and a known cembranolide, lobomichaolide (7) were isolated from the CH2Cl2 extract of the soft coral Lobophytum michaelae. Their structures were established by extensive spectral analysis. The anti-HCMV (human cytomegalovirus) activity of 1-7 and their cytotoxicity against selected cell lines were evaluated. [ABSTRACT FROM AUTHOR]

Published
2012
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5. Chloro-Furanocembranolides from Leptogorgia sp. Improve Pancreatic Beta-Cell Proliferation

Author

José Darias, Jose M. de la Rosa, Mercedes Cueto, Germán Perdomo, Luis D'Croz, Irene Cózar-Castellano, Amalia B. Gallardo, Ana R. Díaz-Marrero, European Commission, Ministerio de Economía y Competitividad (España), and Cabildo de Tenerife

Subjects
Bridged-Ring Compounds, Models, Molecular, diketocembranolides, Magnetic Resonance Spectroscopy, cembranolides, Pharmaceutical Science, Leptogorgia, 010402 general chemistry, 01 natural sciences, Article, Cell Line, Pancreatic beta cell proliferation, Endocrinology, Pancreatic beta Cells, Insulin-Secreting Cells, Drug Discovery, Endocrinología, Animals, Rubifolide, Beta (finance), Furans, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), lcsh:QH301-705.5, Cell Proliferation, biology, Molecular Structure, 010405 organic chemistry, Chemistry, pancreatic beta-cells, chloro-furanocembranolides, biology.organism_classification, Anthozoa, Molecular biology, 0104 chemical sciences, 3. Good health, Rats, Scabrolide D, lcsh:Biology (General), furanocembranolides, seco-furanocembranolides, Oxidation-Reduction
Abstract

This article belongs to the Special Issue Progress on Marine Natural Products as Lead Compounds., Two new chloro-furanocembranolides (1, 2) and two new 1,4-diketo cembranolides (3, 4) were isolated from the crude extract of Leptogorgia sp. together with a new seco-furanocembranolide (5) and the known Z-deoxypukalide (6), rubifolide (7), scabrolide D (8) and epoxylophodione (9). Their structures were determined based on spectroscopic evidence. Four compounds: 1, 2, 7 and 8 were found to activate the proliferation of pancreatic insulin-producing (beta) cells., This work was supported by the Ministerio de Ciencia e Innovación (SAF2009-0839 and RTA 2015-00010-C03-02). ARDM acknowledges funding from IMBRAIN project (FP7-REGPOT-2012-CT2012-31637-IMBRAIN) and from Cabildo de Tenerife (Agustín de Betancourt Programme). A.B.G. would like to thank Convenio Universidad de Magallanes (Chile) and CSIC, project 2009CL0031, for financial support.

Published
2018

6. New cytotoxic cembranolides from the soft coral Lobophytum michaelae.

Author

Wang SK and Duh CY

Subjects
Animals, Antineoplastic Agents chemistry, Antineoplastic Agents isolation & purification, Antiviral Agents chemistry, Antiviral Agents isolation & purification, Cell Line, Tumor, Cytomegalovirus drug effects, Diterpenes chemistry, Diterpenes isolation & purification, Drug Discovery, Humans, Inhibitory Concentration 50, Lactones chemistry, Lactones isolation & purification, Lactones pharmacology, Marine Toxins chemistry, Marine Toxins isolation & purification, Mice, Molecular Structure, Neoplasms drug therapy, Pacific Ocean, Stereoisomerism, Taiwan, Anthozoa chemistry, Antineoplastic Agents pharmacology, Antiviral Agents pharmacology, Diterpenes pharmacology, Marine Toxins pharmacology
Abstract

Six new cembranolides, michaolides L-Q (1-6), and a known cembranolide, lobomichaolide (7) were isolated from the CH₂Cl₂ extract of the soft coral Lobophytum michaelae. Their structures were established by extensive spectral analysis. The anti-HCMV (human cytomegalovirus) activity of 1-7 and their cytotoxicity against selected cell lines were evaluated.

Published
2012
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