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Chloro-Furanocembranolides from Leptogorgia sp. Improve Pancreatic Beta-Cell Proliferation
- Source :
- Marine Drugs; Volume 16; Issue 2; Pages: 49, Digital.CSIC. Repositorio Institucional del CSIC, instname, Repositorio Institucional de la Universidad de Burgos (RIUBU), Marine Drugs, Vol 16, Iss 2, p 49 (2018), Marine Drugs
- Publication Year :
- 2018
- Publisher :
- MDPI, 2018.
-
Abstract
- This article belongs to the Special Issue Progress on Marine Natural Products as Lead Compounds.<br />Two new chloro-furanocembranolides (1, 2) and two new 1,4-diketo cembranolides (3, 4) were isolated from the crude extract of Leptogorgia sp. together with a new seco-furanocembranolide (5) and the known Z-deoxypukalide (6), rubifolide (7), scabrolide D (8) and epoxylophodione (9). Their structures were determined based on spectroscopic evidence. Four compounds: 1, 2, 7 and 8 were found to activate the proliferation of pancreatic insulin-producing (beta) cells.<br />This work was supported by the Ministerio de Ciencia e Innovación (SAF2009-0839 and RTA 2015-00010-C03-02). ARDM acknowledges funding from IMBRAIN project (FP7-REGPOT-2012-CT2012-31637-IMBRAIN) and from Cabildo de Tenerife (Agustín de Betancourt Programme). A.B.G. would like to thank Convenio Universidad de Magallanes (Chile) and CSIC, project 2009CL0031, for financial support.
- Subjects :
- Bridged-Ring Compounds
Models, Molecular
diketocembranolides
Magnetic Resonance Spectroscopy
cembranolides
Pharmaceutical Science
Leptogorgia
010402 general chemistry
01 natural sciences
Article
Cell Line
Pancreatic beta cell proliferation
Endocrinology
Pancreatic beta Cells
Insulin-Secreting Cells
Drug Discovery
Endocrinología
Animals
Rubifolide
Beta (finance)
Furans
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
lcsh:QH301-705.5
Cell Proliferation
biology
Molecular Structure
010405 organic chemistry
Chemistry
pancreatic beta-cells
chloro-furanocembranolides
biology.organism_classification
Anthozoa
Molecular biology
0104 chemical sciences
3. Good health
Rats
Scabrolide D
lcsh:Biology (General)
furanocembranolides
seco-furanocembranolides
Oxidation-Reduction
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Marine Drugs; Volume 16; Issue 2; Pages: 49, Digital.CSIC. Repositorio Institucional del CSIC, instname, Repositorio Institucional de la Universidad de Burgos (RIUBU), Marine Drugs, Vol 16, Iss 2, p 49 (2018), Marine Drugs
- Accession number :
- edsair.doi.dedup.....74884a729299cab4591e5b27e2bb1e6d