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1. Safety and on-treatment efficacy of telaprevir: the early access programme for patients with advanced hepatitis C

Author

Inmaculada Fernández, Wafae Iraqi, Heiner Wedemeyer, D. Abdurakhmanov, I. Lonjon-Domanec, Christophe Moreno, M.L. Colombo, Ralph DeMasi, J.M. Läuffer, Simone I. Strasser, A. Verheyen, Petr Urbánek, Paulo Roberto Abrão Ferreira, Adrian Streinu-Cercel, and Andrew Martin Hill

Subjects
Adult, Liver Cirrhosis, Male, medicine.medical_specialty, Cirrhosis, Genotype, Alpha interferon, Hepacivirus, Interferon alpha-2, Antiviral Agents, Gastroenterology, Drug Administration Schedule, Polyethylene Glycols, Telaprevir, chemistry.chemical_compound, Internal medicine, Ribavirin, medicine, Humans, Prospective Studies, Aged, business.industry, Interferon-alpha, virus diseases, Hepatitis C, Hepatitis C, Chronic, Middle Aged, Sciences bio-médicales et agricoles, medicine.disease, Rash, Recombinant Proteins, digestive system diseases, Surgery, Discontinuation, Treatment Outcome, Tolerability, chemistry, Multivariate Analysis, Linear Models, Drug Therapy, Combination, Female, medicine.symptom, business, Oligopeptides, Follow-Up Studies, medicine.drug
Abstract

Severe adverse events (AEs) compromise the outcome of direct antiviral agent-based treatment in patients with advanced liver fibrosis due to HCV infection. HEP3002 is an ongoing multinational programme to evaluate safety and efficacy of telaprevir (TVR) plus pegylated-interferon-α (PEG-IFNα) and ribavirin (RBV) in patients with advanced liver fibrosis caused by HCV genotype 1 (HCV-1)., JOURNAL ARTICLE, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2013

2. Contents Vol. 16, 1999

Author

M. Caínzos Fernández, Hiroyasu Makuuchi, D. Botsios, Huug Obertop, Stephen O’Neil, J. García Iglesias, T. El-Sefi, C.G. Larsen, H.A. Bruining, J. Gram, N.O. Jacobsen, G. Mai, Thomas M. van Gulik, Masayuki Imamura, H.U. Baer, L.S. Jensen, Akio Morimoto, C.G. Curti, Hjörtur Gislason, Kohichi Fujii, Tun Aung, Hisashi Onodera, S. Agelopoulos, Moshe Schein, A. Rios Rios, M. Osman, H. van Goor, F. Fernández López, Tomoo Tajima, Odd Søreide, C. Dervenis, Shunzo Maetani, Marc A. Borge, Hisao Nakasaki, Asgaut Viste, Kazuyuki Kawamoto, J. Potel Lesquereux, Djamila Boerma, Valeriu E. Andrei, S.L. Jensen, Norio Shiraishi, D. Berchtold, R. Conde Freire, G.L. Ong, S.B. Lausten, L.H. Ottesen, J. Triller, H. Demetriades, Seigo Kitano, Daisuke Ikeuchi, C. Couinaud, Shugen Kan, R.F.A. Weber, Dirk J. Gouma, Leslie Wise, R.F. Fenchel, J. Dadoukis, Takeshi Katsuta, E.M. Bladbjerg, Yosuke Adachi, E. Tønnesen, J.M. Läuffer, J.E.J. Krige, T.M. Ibrahim, P.C. Bornman, M.L. Jacobs, J. Evagelou, H.C.J.L. Buscher, B. Gesser, Gerard V. Aranha, and Masanori Aramaki

Subjects
Traditional medicine, business.industry, Gastroenterology, Medicine, Surgery, business
Published
1999

3. Intrapancreatic Accessory Spleen: A Rare Cause of a Pancreatic Mass

Author

Arthur Zimmermann, Markus W. Büchler, Hans U. Baer, J.M. Läuffer, Markus Wagner, and Christoph A. Maurer

Subjects
Male, Pathology, medicine.medical_specialty, medicine.medical_treatment, Choristoma, Neuroendocrine tumors, Accessory spleen, Endocrinology, Laparotomy, Pancreatic cancer, medicine, Pancreatic mass, Humans, Aged, medicine.diagnostic_test, business.industry, Octreotide scan, Gastroenterology, Pancreatic Diseases, medicine.disease, medicine.anatomical_structure, Oncology, Radiology, Splenic disease, Tomography, X-Ray Computed, Pancreas, business, Spleen
Abstract

The clinical significance of intrapancreatic accessory spleens resides in the mimicry of pancreatic cancer. Radionuclide tests (Octreotide scan and Tc99m sulfur colloid scan) should be undertaken to distinguish these lesions from neuroendocrine tumors, hypervascular metastases and pancreatic carcinoma. If the tests are equivocal, diagnostic laparotomy or laparoscopy is recommended.Despite its relatively common occurrence, intrapancreatic ectopic splenic tissue is rarely detected owing to its asymptomatic nature.We report a case of a clinically asymptomatic patient in which abdominal computed tomography (CT) scans revealed a mass of 1.5 cm in diameter in the distal pancreas. The tumor markers CA 19-9 and carcinoembryonic antigen (CEA) were slightly elevated, and pancreatic neoplasm was suspected.Left pancreatic resection and splenectomy were performed. The removed specimen disclosed the presence of an accessory spleen within the pancreatic tail.

Published
1999

4. Contents, Vol. 14, 1997

Author

I. Waked, Harutsugu Sodeyama, Simon Galloway, Yoshinori Yamashita, Richard A. Prinz, Takashi Nishimura, J.M. Läuffer, P.B. Soeters, Krzysztof Bielecki, Raquel Hernández, M.W. Büchler, T. Ibrahim, Yoshihisa Sode, Irvin M. Modlin, Ken Hayashi, Nobuyuki Kawamura, Philippe Gertsch, S. Boos, A. Sadek, Sven Gustavsson, Leslie H. Blumgart, Mark Kidd, T. El-Seifi, A. Zimmermann, Masao Wakabayashi, Toshihiro Hirai, Jyunichiro Watase, Tomosaburo Sakamoto, Ulf Haglund, A. Shawki, Thomas E. Adrian, Shigeru Imabun, Tsuguo Sakamoto, Christian Seiler, G. Ruf, A. Helmy, Ch.A. Seller, Thomas V. Berne, Hiroyuki Kanno, S. Fetscher, Juan J. Sancho, Kazuhiro Hanazaki, Antonio Sitges-Serra, Abraham Czerniak, A. Heintz, Tadaaki Miyazaki, E.H. Farthmann, Katsuhide Yoshidome, A.H.M. Froon, Tohru Yamazaki, H. Gad, Andras Sandor, Ireneusz Kozicki, J.W.M. Greve, R. Engelhardt, J. Sontheimer, Shiro Yokoyama, Meritxell Girvent, Lars-Erik Hansson, A. Imdahl, Tetsuya Toge, E. Hammad, Andrew N. Kingsnorth, S.Y.G. Peeters, I. Marawan, Michael A. Boss, M. Henke, T. Böttger, and José Crespo Mendes de Almeida

Subjects
Traditional medicine, business.industry, Gastroenterology, Medicine, Surgery, business
Published
1997

5. Contents, Vol. 12, 1995

Author

Milutin Bulajic, C. Vagianos, Itamar Kott, Ashley R. Dennison, Guy J. Maddern, Chrisoula D. Scopa, Leslie H. Blumgart, Ilker Tasdemir, Jon Arne Søreide, M. Stavropoulos, Michael Safioleas, José Hobeika, J. Gogas, Hans U. Baer, A. Arvaniti, W. Schweizer, A. Moreno Egea, Gregory Kouraklis, S. Koureleas, J.L. Aguayo Albasini, M. Gilg, Raphael Reiss, Evangelos P. Misiakos, M.W. Büchler, Georges Delpre, Ofer Landau, Christian Seiler, Christos Dervenis, J. Kirkilesis, Eduard H. Farthmann, Shalom Watemberg, P. Parrilla Paricio, Ram Avrahamy, Miroslav Milicevic, Sigmund Vaage, Ram Avrahami, Antony Papachristodoulou, G. Zambudio Carmona, Kjell Øvrebø, Aaron Sulkes, Michel Huguier, Ami Neeman, E.M. Farthmann, Karl Søndenaa, J.M. Läuffer, B. Štimec, Israel L. Nudelman, U. Schöffel, and Sidney Houry

Subjects
medicine.medical_specialty, business.industry, Internal medicine, General surgery, Gastroenterology, Medicine, Surgery, business
Published
1995

6. Celiac axis infusion chemotherapy in advanced nonresectable pancreatic cancer

Author

Jürgen Triller, J.M. Läuffer, Christoph A. Maurer, Helmut Friess, Markus W. Büchler, Markus Borner, and K. Z'graggen

Subjects
Adult, Male, medicine.medical_specialty, Pancreatic disease, medicine.medical_treatment, 610 Medicine & health, Folinic acid, Endocrinology, Recurrent Pancreatic Carcinoma, Celiac Artery, Pancreatic cancer, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Infusions, Intra-Arterial, Aged, Neoplasm Staging, Chemotherapy, business.industry, Standard treatment, Carcinoma, Ductal, Breast, Palliative Care, Angiography, Gastroenterology, Middle Aged, medicine.disease, Survival Analysis, Surgery, Pancreatic Neoplasms, Radiation therapy, medicine.anatomical_structure, Oncology, Female, Pancreas, business, medicine.drug
Abstract

Summary: Conclusion: Based on these data we suggest that regional intra-arterial chemotherapy for advanced pancreatic cancer seems not to be superior to common treatment modalities, such as combined radiochemotherapy. Background: The prognosis for advanced pancreatic cancer is very poor. No standard treatment is available. Recently, better survival and quality of life was reported from regional cancer treatment via celiac axis infusion. In an attempt to confirm these results we conducted a phase II study of intra-arterial chemotherapy for nonresectable pancreatic cancer. Methods: From May 1994 to February 1995, 12 consecutive patients with biopsy-proven advanced ductal carcinoma of the exocrine pancreas were given intra-arterial infusions consisting of Mitoxantrone, 5-FU+ folinic acid, and Cisplatin via a transfemorally placed catheter in the celiac axis. Six patients were classified as UICC stage III and six as stage IV with the liver as the sole site of distant metastasis. Nine patients had primary and three had recurrent pancreatic carcinoma after a Whipple procedure. Nonresectability of primary tumors was assessed in all patients by laparotomy or laparoscopy. Results: A total of 31 cycles of chemotherapy (mean 2.6 cycles/patient) was administered. Catheter placement was technically feasible in all cycles. A groin hematoma was the only catheter complication. The follow-up by CT sans at 2-mo intervals revealed partial remission in 1 patient (8%), temporary stable disease in 4 patients (33%), and disease progression in 7 patients (58%). The same response was obtained after analyzing the CA 19-9 course. Median survival in stage III patients was 8.5 mo (3-12 mo) and in stage IV patients 5 mo (2-11 mo). Toxicity according to WHO criteria consisted of grade III (4 events), grade II (10 events), and grade I (17 events), mainly resulting from leucopenia and diarrhea/vomiting. Nine of 11 patients experienced temporary relief of pain immediately after regional treatment

Published
1998

7. OC-26 Treatment of hepatitis C genotype 1 patients with severe fibrosis or compensated cirrhosis: the Italian telaprevir early access program

Author

J.M. Läuffer, María Isabel Colombo, Massimo Zuin, Antonio Craxì, P. Andreone, Antonio Picciotto, Andrew M. Hill, Giuseppe Mazzella, and Sergio Babudieri

Subjects
medicine.medical_specialty, Cirrhosis, Hepatology, business.industry, Gastroenterology, Hepatitis C, Severe fibrosis, medicine.disease, Telaprevir, Internal medicine, Genotype, medicine, business, medicine.drug
Published
2013

8. Subject Index Vol. 16, 1999

Author

H.A. Bruining, L.S. Jensen, C.G. Curti, M. Caínzos Fernández, Moshe Schein, C. Couinaud, J. Dadoukis, Takeshi Katsuta, D. Botsios, Huug Obertop, Hiroyasu Makuuchi, Hjörtur Gislason, J. García Iglesias, N.O. Jacobsen, Thomas M. van Gulik, Masayuki Imamura, Hisao Nakasaki, E. Tønnesen, Yosuke Adachi, D. Berchtold, L.H. Ottesen, S. Agelopoulos, J.M. Läuffer, Asgaut Viste, J.E.J. Krige, Hisashi Onodera, Kohichi Fujii, J. Potel Lesquereux, Seigo Kitano, H.U. Baer, R. Conde Freire, Valeriu E. Andrei, S.L. Jensen, H. Demetriades, E.M. Bladbjerg, Norio Shiraishi, Shunzo Maetani, Tun Aung, Marc A. Borge, M. Osman, Tomoo Tajima, J. Gram, Daisuke Ikeuchi, Odd Søreide, G.L. Ong, J. Triller, Shugen Kan, R.F.A. Weber, Leslie Wise, M.L. Jacobs, S.B. Lausten, J. Evagelou, R.F. Fenchel, G. Mai, H. van Goor, Dirk J. Gouma, Gerard V. Aranha, Masanori Aramaki, T.M. Ibrahim, P.C. Bornman, H.C.J.L. Buscher, Akio Morimoto, B. Gesser, Kazuyuki Kawamoto, Stephen O’Neil, F. Fernández López, Djamila Boerma, A. Rios Rios, C. Dervenis, T. El-Sefi, and C.G. Larsen

Subjects
Index (economics), business.industry, Statistics, Gastroenterology, Medicine, Surgery, Subject (documents), business
Published
1999

9. Subject Index Vol. 14, 1997

Author

E. Hammad, Lars-Erik Hansson, T. El-Seifi, S. Boos, Raquel Hernández, Yoshihisa Sode, Krzysztof Bielecki, S.Y.G. Peeters, Tetsuya Toge, Ken Hayashi, Sven Gustavsson, Tadaaki Miyazaki, Simon Galloway, Andrew N. Kingsnorth, Ch.A. Seller, Takashi Nishimura, M. Henke, E.H. Farthmann, Kazuhiro Hanazaki, Katsuhide Yoshidome, Toshihiro Hirai, J. Sontheimer, Christian Seiler, Tsuguo Sakamoto, H. Gad, Harutsugu Sodeyama, Leslie H. Blumgart, Thomas E. Adrian, T. Ibrahim, Masao Wakabayashi, Irvin M. Modlin, A. Sadek, J.W.M. Greve, Yoshinori Yamashita, J.M. Läuffer, P.B. Soeters, José Crespo Mendes de Almeida, S. Fetscher, R. Engelhardt, Jyunichiro Watase, Juan J. Sancho, Michael A. Boss, T. Böttger, A.H.M. Froon, A. Helmy, A. Zimmermann, Tohru Yamazaki, Philippe Gertsch, Mark Kidd, M.W. Büchler, Andras Sandor, Thomas V. Berne, Richard A. Prinz, Shiro Yokoyama, Meritxell Girvent, Antonio Sitges-Serra, Hiroyuki Kanno, Abraham Czerniak, A. Heintz, I. Waked, I. Marawan, A. Imdahl, Ireneusz Kozicki, Nobuyuki Kawamura, Ulf Haglund, A. Shawki, Shigeru Imabun, G. Ruf, and Tomosaburo Sakamoto

Subjects
Index (economics), business.industry, Statistics, Gastroenterology, Medicine, Surgery, Subject (documents), business
Published
1997

10. Author lndex Vol. 14, 1997

Author

P.B. Soeters, S. Fetscher, Juan J. Sancho, A. Zimmermann, Christian Seiler, A. N. Kingsnorth, M.W. Büchler, Philippe Gertsch, Irvin M. Modlin, J.W.M. Greve, S. Boos, A. Sadek, R. Engelhardt, Masao Wakabayashi, Jyunichiro Watase, Nobuyuki Kawamura, Tadaaki Miyazaki, Shigeru Imabun, Leslie H. Blumgart, Ulf Haglund, G. Ruf, E.H. Farthmann, Katsuhide Yoshidome, Tomosaburo Sakamoto, Michael A. Boss, Harutsugu Sodeyama, A. Shawki, Raquel Hernández, H. Gad, Kazuhiro Hanazaki, Lars-Erik Hansson, Yoshihisa Sode, Thomas V. Berne, Shiro Yokoyama, Yoshinori Yamashita, Sven Gustavsson, Hiroyuki Kanno, Meritxell Girvent, I. Waked, Ch.A. Seller, A. Imdahl, Ken Hayashi, Simon Galloway, Richard A. Prinz, T. Ibrahim, Thomas E. Adrian, Mark Kidd, Krzysztof Bielecki, Toshihiro Hirai, Antonio Sitges-Serra, Abraham Czerniak, A. Heintz, A. Helmy, Takashi Nishimura, Tsuguo Sakamoto, T. Böttger, M. Henke, Ireneusz Kozicki, José Crespo Mendes de Almeida, A.H.M. Froon, Tohru Yamazaki, Andras Sandor, J. Sontheimer, I. Marawan, T. El-Seifi, Tetsuya Toge, E. Hammad, S.Y.G. Peeters, and J.M. Läuffer

Subjects
medicine.medical_specialty, business.industry, Internal medicine, General surgery, Gastroenterology, Medicine, Surgery, business
Published
1997

11. Author lndex Vol. 12, 1995

Author

Evangelos P. Misiakos, C. Vagianos, M.W. Büchler, Itamar Kott, Ashley R. Dennison, Hans U. Baer, Georges Delpre, J. Gogas, J.L. Aguayo Albasini, W. Schweizer, Christian Seiler, A. Moreno Egea, Raphael Reiss, Sigmund Vaage, Ilker Tasdemir, Christos Dervenis, Ram Avrahami, S. Koureleas, Ram Avrahamy, Ami Neeman, E.M. Farthmann, Gregory Kouraklis, José Hobeika, Miroslav Milicevic, M. Gilg, U. Schöffel, J.M. Läuffer, Sidney Houry, Shalom Watemberg, A. Arvaniti, J. Kirkilesis, Eduard H. Farthmann, Jon Arne Søreide, Michel Huguier, Guy J. Maddern, Chrisoula D. Scopa, Leslie H. Blumgart, Antony Papachristodoulou, Kjell Øvrebø, Aaron Sulkes, G. Zambudio Carmona, P. Parrilla Paricio, M. Stavropoulos, Ofer Landau, Michael Safioleas, Milutin Bulajic, B. Štimec, Israel L. Nudelman, and Karl Søndenaa

Subjects
business.industry, Gastroenterology, Library science, Medicine, Surgery, business
Published
1995

12. Subject Index Vol. 12, 1995

Author

C. Vagianos, A. Arvaniti, Itamar Kott, Ashley R. Dennison, J. Gogas, Shalom Watemberg, J.M. Läuffer, Evangelos P. Misiakos, B. Štimec, S. Koureleas, Guy J. Maddern, Michael Safioleas, U. Schöffel, Sidney Houry, Michel Huguier, Israel L. Nudelman, Ami Neeman, E.M. Farthmann, P. Parrilla Paricio, Georges Delpre, Antony Papachristodoulou, Karl Søndenaa, Raphael Reiss, Jon Arne Søreide, J.L. Aguayo Albasini, J. Kirkilesis, Eduard H. Farthmann, Chrisoula D. Scopa, Ofer Landau, Leslie H. Blumgart, Kjell Øvrebø, Aaron Sulkes, M. Stavropoulos, Christian Seiler, Ilker Tasdemir, Milutin Bulajic, A. Moreno Egea, Hans U. Baer, José Hobeika, W. Schweizer, Sigmund Vaage, Ram Avrahami, M.W. Büchler, Ram Avrahamy, G. Zambudio Carmona, Miroslav Milicevic, Christos Dervenis, Gregory Kouraklis, and M. Gilg

Subjects
medicine.medical_specialty, Index (economics), business.industry, Internal medicine, Gastroenterology, Medicine, Surgery, Subject (documents), Medical physics, business
Published
1995

13. Subject Index Vol. 62, 2000

Author

Amedeo C. Fantin, Zubair H. Khan, Bernhard Egger, Irvin M. Modlin, Louis M. A. Akkermans, Tomoko Seya, Mona Bajaj-Elliott, Antonio Carroccio, Giuseppe Montalto, Daniel Aeberli, Jan Borovicka, Arthur Zimmermann, John F. Mayberry, Markus W. Büchler, Christa Meyenberger, Hein G. Gooszen, B. Masoud, J.M. Läuffer, Viktor E. Eysselein, Emilio Iannitto, Sofie Schmid, J.A. Louw, Timo Kirschstein, Michael Vieth, Laura H. Tang, Nicky Spiers, Janek Binek, Vincent B. Nieuwenhuijs, Mark Kidd, E Fabiani, Lydia Giannitrapani, Walter R. Suter, Jörg Neuweiler, Yoshiyuki Takahashi, Manfred Stolte, Masahiko Onda, Chi H. Cho, Noritake Tanaka, Fabio Gravina, Alexander Meining, Carlo Catassi, Thomas T. MacDonald, Roman Inglin, Waldemar Uhl, A. C. B. Wicks, Edgar S.L. Liu, and Jaap E. van Dijk

Subjects
Index (economics), Statistics, Gastroenterology, Subject (documents), Mathematics
Published
2000

14. Contents Vol. 62, 2000

Author

Louis M. A. Akkermans, Sofie Schmid, Mark Kidd, J.A. Louw, Bernhard Egger, Jörg Neuweiler, Emilio Iannitto, Giuseppe Montalto, Daniel Aeberli, Jan Borovicka, Noritake Tanaka, Manfred Stolte, John F. Mayberry, Vincent B. Nieuwenhuijs, Carlo Catassi, Tomoko Seya, Amedeo C. Fantin, Roman Inglin, Waldemar Uhl, Zubair H. Khan, Alexander Meining, Thomas T. MacDonald, Walter R. Suter, Irvin M. Modlin, A. C. B. Wicks, Markus W. Büchler, Christa Meyenberger, Arthur Zimmermann, Chi H. Cho, Masahiko Onda, Michael Vieth, Lydia Giannitrapani, Nicky Spiers, J.M. Läuffer, Edgar S.L. Liu, E Fabiani, Antonio Carroccio, Laura H. Tang, Janek Binek, B. Masoud, Mona Bajaj-Elliott, Jaap E. van Dijk, Viktor E. Eysselein, Hein G. Gooszen, Timo Kirschstein, Yoshiyuki Takahashi, and Fabio Gravina

Subjects
Gastroenterology
Published
2000

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