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A recent study conducted by Kyushu University in Fukuoka, Japan, focused on the characterization of two bacteriophages targeting Campylobacter jejuni, a common cause of foodborne illness. The research found that these phages, when combined with EDTA, effectively reduced C. jejuni contamination in food products. While the phages showed promise in inhibiting bacterial growth, they were not directly applicable for food safety due to being lysogenic. This study contributes to expanding the genome library of C. jejuni phages and offers potential strategies for controlling the bacteria. [Extracted from the article]

A recent study conducted by Kyushu University in Fukuoka, Japan, explored the impact of mucilage and low omega-3 fatty acid contents in phytoplankton on the dietary quality for zooplankton, specifically Daphnia pulicaria. The research found that phytoplankton with mucilage had decreased dietary quality, particularly among green algae, while those without mucilage had higher omega-3 fatty acid contents, enhancing their quality as a diet for zooplankton. The presence of mucilage was shown to reduce ingestion and digestion by zooplankton, potentially negatively impacting lake ecosystems. This peer-reviewed study sheds light on the importance of understanding the composition of phytoplankton diets for maintaining ecological balance. [Extracted from the article]

A study conducted at Kurume University Hospital in Fukuoka, Japan, explored the role of CXCR4 expression and cancer-associated fibroblasts in the invasion of low-grade endometrioid carcinoma. The research found that CXCR4 expression significantly reflected myometrial invasion in endometrioid carcinoma cases, indicating its potential as an independent factor in diagnostic evaluation before treatment. This study sheds light on the heterogeneous behavior of well-differentiated endometrioid carcinoma and highlights the importance of accurate evaluation for treatment strategies, especially in cases considering fertility preservation. [Extracted from the article]

A study conducted at Kyushu University in Fukuoka, Japan, focused on the clinical significance of the tumor immune microenvironment in endometrial endometrioid carcinoma, grade 1, with DNA mismatch repair protein loss. The research highlighted the impact of the tumor immune microenvironment on clinicopathological features within the group with mismatch repair protein loss, which is the main target for immune checkpoint inhibitors in endometrioid carcinoma, grade 1. The study emphasized the need for further research, including on patients who have been administered immune checkpoint inhibitors. [Extracted from the article]

A study conducted at Kyushu University Hospital in Fukuoka, Japan, explored the effects of acute dapagliflozin administration on cardiac surgery-associated acute kidney injury in a rabbit model. The research found that dapagliflozin administration led to reduced serum creatinine and blood urea nitrogen concentrations, increased urine output, and improved tubular injury scores. The study concluded that dapagliflozin may have direct renoprotective effects in renal tubular cells. This research was published in the Circulation Journal and has been peer-reviewed. [Extracted from the article]

Researchers from the University of Occupational and Environmental Health in Fukuoka, Japan, conducted a study on iron overload induced by tocilizumab, an anti-interleukin-6 receptor antibody, in a 75-year-old woman with rheumatoid arthritis. The patient developed liver dysfunction one year after starting tocilizumab treatment, leading to a diagnosis of hepatic iron overload. Ceasing tocilizumab and undergoing phlebotomy improved the patient's liver function, highlighting the importance of monitoring iron status in patients receiving tocilizumab. The research emphasizes the need to be cautious of tocilizumab-induced iron overload in susceptible individuals. [Extracted from the article]

Researchers at Kyushu University in Fukuoka, Japan, have conducted a study on Xeroderma Pigmentosum, a genetic skin disease. The study focused on the use of triamcinolone acetonide for treating hypertrophic scars associated with the condition. The research highlighted the advantages of transdermal delivery of the medication to reduce side effects and improve therapeutic efficacy. This peer-reviewed study provides valuable insights into the treatment of Xeroderma Pigmentosum and can be accessed through the European Journal of Dermatology. [Extracted from the article]

A recent study conducted by Kyushu University in Fukuoka, Japan, focused on enhancing the antimicrobial properties of sodium alginate film used in food packaging. By incorporating peppermint essential oil and Japanese rice vinegar into the film, researchers observed improved prevention of fungal growth and spore germination. The combination of vinegar and essential oil was found to be particularly effective in enhancing the performance of food packaging, as reported in the International Journal of Biological Macromolecules. For more information, readers can contact Leila Mohammadi at Kyushu University in Japan. [Extracted from the article]

A recent study from Kyushu University in Fukuoka, Japan, focused on primary intraosseous carcinoma NOS (PIOC), a rare type of odontogenic tumor with a poor prognosis. The research highlighted the transition from odontogenic keratocyst to carcinoma in PIOC, emphasizing the malignant attributes of the tumor. The study suggested that the activation of YAP signaling by Wnt/(3-catenin signaling may play a role in the pathogenesis of PIOC. [Extracted from the article]

A recent study conducted by Kyushu University Graduate School in Fukuoka, Japan, focused on producing Norovirus virus-like particles (VLPs) of nine genotypes prevalent in Japan using the silkworm-baculovirus expression vector system. The research aimed to develop a multivalent vaccine against genetically diverse Norovirus infections, as the virus is a major cause of acute viral gastroenteritis in humans. The study successfully demonstrated the utility of the silkworm-BEVS in producing VLPs of multiple genotypes, laying the groundwork for potential vaccine development. The research has been peer-reviewed and offers valuable insights into combating Norovirus infections. [Extracted from the article]

A study conducted by investigators from Kyushu University in Japan examined Chinese consumers' responsiveness towards contaminated imported cold chain seafood, specifically focusing on the role of trust in government information, risk perception, and risk preferences on purchasing behavior. The research found that the interaction between risk perception and risk preference positively influenced actual purchasing behavior, while trust in government information did not directly impact consumer behavior. Subgroup regressions revealed city heterogeneity in the effect of trust in government information on purchasing behavior. This peer-reviewed study sheds light on the complex factors influencing consumer decisions in the context of food safety and contamination issues. [Extracted from the article]

Researchers at Fukuoka University conducted a prospective cohort study to assess the incidence and clinical outcomes of lateral femoral cutaneous nerve (LFCN) injury after periacetabular osteotomy (PAO) over a minimum three-year follow-up period. They found that 50% of patients experienced symptoms of LFCN injury one year after PAO, with 33% still experiencing symptoms at three years postoperatively. Patients with persistent symptoms had poorer outcomes in terms of patient satisfaction and mental health scores. The study highlights the high incidence of LFCN injury after PAO and its impact on long-term clinical outcomes. [Extracted from the article]

A study conducted at the International University of Health & Welfare in Fukuoka, Japan, examined factors in individuals diagnosed with hyperglycemia during periodic medical checkups. The study included 9,324 subjects who visited Takagi Hospital for checkups in 2019. The researchers found that BMI, waist circumference, blood pressure, and fatty liver were higher in cases of hyperglycemia compared to controls. They also identified several risk factors for hyperglycemia, including BMI, waist circumference, blood pressure, triglyceride levels, ALT, and y-GTP. These risk factors were already elevated in individuals one or two years before the diagnosis of hyperglycemia. [Extracted from the article]

A recent study conducted by researchers at Kyushu University in Fukuoka, Japan, has developed edible films made of sodium alginate and kiwifruit seed essential oil (KSO) to enhance the quality and shelf life of persimmon fruit. The films were found to increase viscosity and opacity, improve thermal stability and elongation at break, and reduce weight loss in the fruit. The study suggests that incorporating sodium alginate with KSO could be a promising coating material for prolonging the shelf life of persimmon fruit, and partial coating may be a more economical alternative to full coating. The research has been peer-reviewed and published in the journal Food Packaging and Shelf Life. [Extracted from the article]

The article offers information on the treatment of hepatocellular adenomas (HCAs) in a patient with Cornelia de Lange Syndrome (CdLS) and congenital portosystemic shunt (CPSS) using transcatheter arterial embolization (TAE). Topics discussed include the association between CdLS and HCAs; the effectiveness of TAE in reducing tumor size; and the implications for managing liver tumors in patients with CdLS.

The article focuses on the development of protein-based Fc-binding antibody-recruiting molecules (Fc-ARMs) that can induce antibody-dependent cellular cytotoxicity (ADCC) and their potential to overcome limitations of previous Fc-ARMs. Topics include the design and testing of protein-based Fc-ARMs with HER2-specific affibodies, the affinity of the Fc-ARMs for IgGs, and the requirement for further enhancement of the affinity of the antibody-binding terminus.

A report from Kyushu University in Fukuoka, Japan, discusses the use of bacteriophages and nisin to control multidrug-resistant Bacillus cereus in various food matrices. The researchers isolated and characterized six bacteriophages that showed activity against toxin-producing and multidrug-resistant strains of B. cereus. The most promising phage, vB_BceS-M2, demonstrated a broad host range and stability over a wide range of temperatures and pH values. When combined with nisin, the phage showed enhanced antimicrobial efficacy against B. cereus in food, reducing its growth rate. The study suggests that this combination could be an effective intervention against toxigenic and antibiotic-resistant B. cereus in food. [Extracted from the article]

A report from Kyushu University in Fukuoka, Japan discusses the findings of a study on community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections. The study analyzed the genome sequences of 151 CA-MRSA isolates, including those from an outbreak in a regional community. The analysis revealed that the outbreak was caused by two sublineages of the CA-MRSA clone already present in the region. The study also found that mobile genetic elements (MGEs) played a significant role in the genomic changes of the CA-MRSA clone during transmission in the community. This research provides insights into how CA-MRSA genomes evolve during community transmission and the involvement of MGEs in this process. [Extracted from the article]

A recent report from Kyushu University in Fukuoka, Japan, explores the use of bone marrow niches created through in vivo engineering using carbonate apatite honeycomb scaffolds. The study investigates the potential of these scaffolds in restoring hematopoietic function and immunity. The researchers found that the scaffolds exhibited a significant increase in the number of stored hematopoietic stem cells compared to actual bone marrow. Transplanting the honeycomb scaffold into immunocompromised mice restored hematopoietic function and the number of immunocytes to normal levels. This research contributes to the development of efficient hematopoietic stem cell transplantation techniques. [Extracted from the article]

A recent study conducted by researchers at Kyushu University in Fukuoka, Japan, explored the use of bacteriophages and cinnamon oils as natural antimicrobial substances to combat Listeria monocytogenes, a pathogenic bacterium that can cause foodborne illnesses. The researchers isolated nine bacteriophages from raw chickens that exhibited lytic activities against L. monocytogenes. They found that the combination of a specific bacteriophage (vB_LmoS-PLM9) and cinnamon oils showed the highest efficiency in reducing the viable counts of L. monocytogenes in milk and inhibiting the regrowth of resistant cell populations. The study suggests that this combination could be a potential approach for controlling L. monocytogenes in milk. [Extracted from the article]

A recent study conducted by researchers at Kyushu University in Fukuoka, Japan, has found that flavonoids, specifically myricetin and quercetin, can increase the susceptibility of Escherichia coli (E. coli) to phages. The study also showed that pretreatment with flavonoids decreased the transcription of chaperone genes in E. coli. These findings provide a scientific basis for the development of a novel biocontrol method for foodborne bacteria. The research was supported by Grants-in-Aid for Scientific Research. [Extracted from the article]

A recent study conducted by Kyushu University in Fukuoka, Japan, explored the association between serum triglyceride (TG) levels and the progression of chronic kidney disease (CKD). The study followed 4,100 patients with CKD for 5 years and found that individuals with high serum TG levels were more likely to experience CKD progression. However, the significance of this association disappeared after adjusting for macroalbuminuria, indicating that the relationship between high TG levels and CKD progression may be mediated by elevated macroalbuminuria. Further research is needed to fully understand the mechanisms at play. [Extracted from the article]

A recent study conducted by researchers at Kyushu University in Fukuoka, Japan, has explored the use of oral administration of PLGA nanoparticles to deliver antisense oligonucleotides (ASOs) to treat inflammatory bowel disease (IBD). The researchers prepared ASO-encapsulated nanoparticles using a water-in-oil-in-water method and found that the nanoparticles had a suitable size for penetration of the mucus layer and accumulation in inflammatory lesions in the intestine. When administered orally to mice with colitis, the nanoparticles reduced target gene expression in the colons and rectums, unlike naked ASO administration. The researchers concluded that these nanoparticles have the potential to be promising oral carriers of ASOs for the treatment of IBD, specifically targeting inflammatory lesions in the gastrointestinal tract and reducing non-specific toxic effects. [Extracted from the article]

A study conducted by investigators from Kyushu University in Fukuoka, Japan, examined the impact of age on prescribing patterns of cardiovascular medications in older Japanese patients with non-dialysis-dependent chronic kidney disease (CKD). The study found that older patients with CKD were less likely to receive renin-angiotensin system (RAS) inhibitors and more likely to receive calcium channel blockers. The proportion of anticoagulation prescriptions for patients with CKD and atrial fibrillation decreased with age, while the proportion of antiplatelet therapy increased linearly with age. The study suggests that age may be a barrier to the treatment of patients with CKD and highlights the need for individualized treatment strategies for cardiovascular protection in this population. [Extracted from the article]

Researchers at Kyushu University in Fukuoka, Japan have conducted a study on the time-dependent differences in vancomycin sensitivity of macrophages, which underlie vancomycin-induced acute kidney injury (AKI). Vancomycin is commonly used to treat drug-resistant bacterial infections but can cause AKI. The study found that the time of administration of vancomycin affected the induction of AKI in mice, with markers of AKI only observed when the drug was administered at a specific time. The research suggests the need for time-dependent considerations in the prevention of vancomycin-induced AKI and the potential for macrophage-targeted AKI therapy. [Extracted from the article]

A recent report from Kurume University in Fukuoka, Japan discusses a case of a 35-year-old Japanese woman with a rare autoimmune bullous disease called Immunoglobulin A (IgA) pemphigus. The woman also had IgA type multiple myeloma, a type of cancer. The patient experienced pruritic papulovesicles on her lower legs and trunk, and further examination revealed hyper-IgA globulinemia and increased plasma cells in the bone marrow, confirming the diagnosis of IgA type multiple myeloma. Treatment with DLd therapy was effective for both the cancer and the skin lesions. The report emphasizes the importance of clinicians being aware of the development of multiple myeloma in patients with IgA pemphigus. [Extracted from the article]

A recent study conducted at Kyushu University in Fukuoka, Japan, has provided new information about ulcerative colitis (UC). The study focused on the effects of ustekinumab (UST), an interleukin-12/23p40 antibody, on circulating T cells in patients with UC. The researchers found that UST treatment decreased the percentage of Th17 cells, which are involved in the pathogenesis of UC, while increasing the percentage of Th1 cells. Additionally, patients with higher levels of Th17 cells showed better improvement in their symptoms after UST treatment. These findings suggest that UST may have an anti-inflammatory effect on UC. [Extracted from the article]

A study conducted by researchers at Fukuoka University in Japan has found that the gut bacterial composition is altered in patients with chronic kidney disease (CKD). The study analyzed the gut microbiota of 93 individuals, including those with CKD and a control group. The researchers discovered that butyrate-producing bacteria were more abundant in the control group compared to the CKD group, and the composition of the gut bacteria deteriorated from CKD stage 3b. The study also found that even after renal replacement therapy, the bacterial composition did not change. This research provides valuable insights into the relationship between gut microbiota and CKD. [Extracted from the article]

Researchers at Kyushu University Hospital in Fukuoka, Japan have reported new findings on Klippel-Trenaunay-Weber Syndrome (KTS), a condition characterized by port-wine stains, vascular malformations, and tissue and bone hypertrophy. The researchers successfully treated a 66-year-old woman with KTS who was experiencing chyluria and hematuria, complications for which there is currently no effective treatment. They performed multiple lymphaticovenular anastomoses (LVAs) to reduce lymphatic fluid flow through a lymphatic-ureteral fistula, resulting in the resolution of chyluria and hematuria. The research concludes that multiple LVAs can definitively treat chyluria caused by a lymphatic-ureteral fistula in patients with KTS. [Extracted from the article]

Researchers from the University of Kitakyushu in Fukuoka, Japan have developed cyclodextrin-based nanoparticles that successfully encapsulate a hydrophobic xanthone compound called alpha-mangostin (MGS). These nanoparticles showed anticancer efficacy in vivo, specifically the beta-cyclodextrin-based nanoparticles containing MGS. The researchers aimed to create libraries of beta-cyclodextrin-based nanoparticles, characterize them, and understand the relationship between physical parameters, release behavior, and anticancer efficacy. They found that the release behavior of MGS from the nanoparticles, characterized by the lifetime of complexes tau(2), can be a critical quality attribute for designing the nanoparticles. [Extracted from the article]

Researchers from Kyushu University in Fukuoka, Japan have developed a gene delivery carrier that responds to the activated c-Src protein-tyrosine kinase. The carrier consists of a neutral main chain with a peptide substrate of c-Src, and when phosphorylated in the presence of c-Src, it releases DNA. In vitro and in vivo experiments showed that the carrier enabled specific gene expression in cells and tumors. This research provides promising insights into cancer gene therapy and the potential for targeted treatment. [Extracted from the article]

A new report from Kyushu University in Fukuoka, Japan discusses the prevalence and prognostic significance of high-risk human papillomavirus (HR-HPV) in squamous cell carcinoma of the hypopharynx, larynx, and oropharynx. The study found that HR-HPV infection was observed in 24% of tumors, with a higher prevalence in oropharyngeal squamous cell carcinoma (64.6%) compared to hypopharyngeal and laryngeal squamous cell carcinoma (0.4%). In cases of combined-type squamous cell carcinoma involving multiple sites, HR-HPV infection was observed in 25% of cases. The study suggests that HR-HPV infection may be rare in pure hypopharyngeal and laryngeal squamous cell carcinoma and that it may not improve prognosis in advanced disease stages. Further research with larger cohorts is needed to confirm these findings. [Extracted from the article]

A recent study conducted by researchers at Kyushu University in Fukuoka, Japan, aimed to identify genes involved in phage resistance in Escherichia coli O157:H7, a foodborne pathogen. The researchers screened 3,909 single gene-deletion mutants of E. coli and found that 10 gene-deletion mutants showed increased susceptibility to a specific phage. Among these mutants, the priA gene-deletion strain showed significant susceptibility to the phage. The researchers also investigated substances that inhibit the function of primosomal protein A (PriA) and found that they had synergistic effects with the phage against E. coli O157:H7. These findings suggest that the combination of PriA inhibitors and phages could be a promising biocontrol tool. [Extracted from the article]

Researchers at Kyushu University in Fukuoka, Japan have conducted a study on the effects of breast cancer cell-derived extracellular vesicles (EVs) on osteoblast differentiation and functions. The study found that these EVs inhibit the maturation of osteoblasts, which are responsible for bone formation. The researchers also discovered that the EVs regulate the activity of c-Jun N-terminal kinase (JNK), a protein involved in osteoblast differentiation. This research provides new insights into the impact of bone metastasis and the role of EVs in osteoblast differentiation. [Extracted from the article]

Researchers at Kyushu University in Fukuoka, Japan have made progress in the field of supramolecular research by developing a method called triplet dynamic nuclear polarization (DNP) to improve the sensitivity of magnetic resonance imaging (MRI). This technique has potential applications in cancer diagnosis using hyperpolarized C-13-labeled pyruvate. The researchers used supramolecular complexation with beta-cyclodextrin to disperse a hydrophilic pentacene derivative, allowing for the transfer of polarization from photoexcited triplet electron spins to the C-13 spins of sodium pyruvate. This development is an important step towards the widespread use of ultra-sensitive MRI for cancer diagnosis. [Extracted from the article]

A recent study conducted at Kyushu University Hospital in Fukuoka, Japan, examined the effects of ondansetron on postoperative nausea and vomiting (PONV) and food intake in Japanese women undergoing laparoscopic gynecological surgery. The study included 632 adult patients and found that ondansetron administration during surgery was associated with a decreased risk of PONV, but did not have a significant impact on food intake the day after surgery. The study concluded that preventing PONV is important for postoperative recovery, and ondansetron can be effective in achieving this goal. This research has been peer-reviewed. [Extracted from the article]

A study conducted at Kyushu University in Fukuoka, Japan, explored the use of a new MRI reconstruction technique called Multi-Resolution Convolutional Neural Network (MR CNN) for brain tumor classification. The researchers used the Figshare brain tumor dataset, consisting of 3064 T1-weighted contrast-enhanced MRI scans, to train the MR CNN model. They found that the proposed brain tumor classifier achieved a classification accuracy of 92.79% for a 10% sampling rate, outperforming other methods. The study concluded that MR CNN significantly improves the accuracy of brain tumor classification based on tumor location using under-sampled k-space signals. This research has been peer-reviewed. [Extracted from the article]

Keywords: Fukuoka; Japan; Asia; Cancer; Carcinomas; Health and Medicine; Hemic and Immune Systems; Immunology; Lymph Nodes; Lymphoid Tissue; Oncology; Risk and Prevention; Squamous Cell Carcinoma EN Fukuoka Japan Asia Cancer Carcinomas Health and Medicine Hemic and Immune Systems Immunology Lymph Nodes Lymphoid Tissue Oncology Risk and Prevention Squamous Cell Carcinoma 1327 1327 1 11/06/23 20231107 NES 231107 2023 NOV 6 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Oncology Week -- A new study on Oncology - Squamous Cell Carcinoma is now available. The news correspondents report that additional information may be obtained from Kaori Koga, Fukuoka University Hospital, Dept. of Pathology, 7-45-1 Nanakuma, Jonan Ku, Fukuoka 8140180, Japan. [Extracted from the article]

According to news reporting originating from Fukuoka, Japan, by NewsRx correspondents, research stated, "Pancreatic undifferentiated carcinoma (UDC) is a rare tumor with a worse prognosis than pancreatic ductal adenocarcinoma (PDAC). Fukuoka, Japan, Asia, Biomarkers, Cancer, Carcinomas, Diagnostics and Screening, Gastroenterology, Health and Medicine, Intermediate Filament Proteins, Oncology, Pancreas, Vimentin Keywords: Fukuoka; Japan; Asia; Biomarkers; Cancer; Carcinomas; Diagnostics and Screening; Gastroenterology; Health and Medicine; Intermediate Filament Proteins; Oncology; Pancreas; Vimentin EN Fukuoka Japan Asia Biomarkers Cancer Carcinomas Diagnostics and Screening Gastroenterology Health and Medicine Intermediate Filament Proteins Oncology Pancreas Vimentin 1487 1487 1 11/06/23 20231106 NES 231106 2023 NOV 6 (NewsRx) -- By a News Reporter-Staff News Editor at Gastroenterology Week -- Fresh data on Oncology - Carcinomas are presented in a new report. [Extracted from the article]