Investigators from Kyushu University Zero in on Cancer Gene Therapy (Activated Tyrosine Kinase C-src-responsive Artificial Gene Carrier: in Vitro and in Vivo Evaluation).

Researchers from Kyushu University in Fukuoka, Japan have developed a gene delivery carrier that responds to the activated c-Src protein-tyrosine kinase. The carrier consists of a neutral main chain with a peptide substrate of c-Src, and when phosphorylated in the presence of c-Src, it releases DNA. In vitro and in vivo experiments showed that the carrier enabled specific gene expression in cells and tumors. This research provides promising insights into cancer gene therapy and the potential for targeted treatment. [Extracted from the article]