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7 results on '"Borras, Ana M"'

1. Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer

Author

Engelman, Jeffrey A., Mukohara, Toru, Zejnullahu, Kreshnik, Lifshits, Eugene, Borras, Ana M., Gale, Christopher-Michael, Naumov, George N., Yeap, Beow Y., Jarrell, Emily, Sun, Jason, Tracy, Sean, Zhao, Xiaojun, Heymach, John V., Johnson, Bruce E., Cantley, Lewis C., and Janne, Pasi A.

Subjects
Endothelial growth factors -- Research, Adenocarcinoma -- Drug therapy, Gefitinib -- Dosage and administration, Gefitinib -- Complications and side effects
Abstract

EGFR is frequently mutated and amplified in lung adenocarcinomas sensitive to EGFR inhibitors gefitinib and erlotinib. A secondary mutation, T790M, has been associated with acquired resistance but has not been [...]

Published
2006

2. Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing

Author

Thomas, Roman K, Nickerson, Elizabeth, Simons, Jan F, Janne, Pasi A, Tengs, Torstein, Yuza, Yuki, Garraway, Levi A, LaFramboise, Thomas, Lee, Jeffrey C, Shah, Kinjal, O'Neill, Keith, Sasaki, Hidefumi, Lindeman, Neal, Wong, Kwok-Kin, Borras, Ana M, Gutmann, Edward J, Dragnev, Konstantin H, DeBiasi, Ralph, Chen, Tzu-Hsiu, Glatt, Karen A, Greulich, Heidi, Desany, Brian, Lubeski, Christine K, Brockman, William, Alvarez, Pablo, Hutchison, Stephen K, Leamon, J H, Ronan, Michael T, Turenchalk, Gregory S, Egholm, Michael, Sellers, William R, Rothberg, Jonathan M, and Meyerson, Matthew

Abstract

The sensitivity of conventional DNA sequencing in tumor biopsies is limited by stromal contamination and by genetic heterogeneity within the cancer. Here, we show that microreactor-based pyrosequencing can detect rare cancer-associated sequence variations by independent and parallel sampling of multiple representatives of a given DNA fragment. This technology can thereby facilitate accurate molecular diagnosis of heterogeneous cancer specimens and enable patient selection for targeted cancer therapies. NOTE:: In the version of this article initially published, it should have been acknowledged that Jan F. Simons, in addition to Roman K. Thomas and Elizabeth Nickerson, contributed equally to this work. The error has been corrected in the HTML and PDF versions of the article., Author(s): Roman K Thomas [1, 2, 12]; Elizabeth Nickerson [3, 12]; Jan F Simons [3, 11, 12]; Pasi A Janne [1]; Torstein Tengs [1, 2]; Yuki Yuza [1]; Levi A [...]

Published
2006
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5. A Rapid and Sensitive Enzymatic Method for Epidermal Growth Factor Receptor Mutation Screening

Author

Jänne, Pasi A., primary, Borras, Ana M., additional, Kuang, Yanan, additional, Rogers, Andrew M., additional, Joshi, Victoria A., additional, Liyanage, Hema, additional, Lindeman, Neal, additional, Lee, Jeffrey C., additional, Halmos, Balazs, additional, Maher, Elizabeth A., additional, Distel, Robert J., additional, Meyerson, Matthew, additional, and Johnson, Bruce E., additional

Published
2006
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