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Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer
- Source :
- Journal of Clinical Investigation. Oct, 2006, Vol. 116 Issue 10, p2695, 12 p.
- Publication Year :
- 2006
-
Abstract
- EGFR is frequently mutated and amplified in lung adenocarcinomas sensitive to EGFR inhibitors gefitinib and erlotinib. A secondary mutation, T790M, has been associated with acquired resistance but has not been [...]
Details
- Language :
- English
- ISSN :
- 00219738
- Volume :
- 116
- Issue :
- 10
- Database :
- Gale General OneFile
- Journal :
- Journal of Clinical Investigation
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.152745362