1. A Fe 2 O 3 /CNx cascade nanoreactor with dual-enzyme-mimetic activities for cancer hypoxia relief to amplify chemo/photodynamic therapy.
- Author
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Gan L, Xia Y, Lv J, Xie J, Yan Y, and Chen Y
- Subjects
- Animals, Humans, Mice, Female, Reactive Oxygen Species metabolism, Cell Proliferation drug effects, Cell Survival drug effects, Mice, Inbred BALB C, Cell Line, Tumor, Hydrogen Peroxide metabolism, Antineoplastic Agents pharmacology, Antineoplastic Agents chemistry, Particle Size, Photochemotherapy, Photosensitizing Agents pharmacology, Photosensitizing Agents chemistry, Tumor Hypoxia drug effects, Ferric Compounds chemistry, Ferric Compounds pharmacology
- Abstract
Reactive oxygen species (ROS)-mediated therapeutic strategies, including chemodynamic therapy (CDT), photodynamic therapy (PDT), and their combination, are effective for treating cancer. Developing a nanoreactor with combined functions of catalase (CAT) and peroxidase (POD) that can simultaneously convert excess H
2 O2 in tumors into O2 required for type II PDT and hydroxyl radicals (•OH) for CDT can help achieve combined therapy. Here, we reported on a safe Fe2 O3 /CNx nanoreactor with dual enzyme simulated activity, in which CNx sheet was the carrier and reducing agent to convert Fe2 O3 to Fe2+ . After modified by MgO2 and photosensitizer Ce6, MgO2 -Fe2 O3 /CNx-Ce6 (MFCC) platform integrated multiple functions, including photosensitizer delivery, compensated H2 O2 continuous supply, relieve of hypoxia, generation of •OH and consumption of GSH into a single formulation. Under 660 nm irradiation for 4 min, MFCC actives more ROS to conduct PDT/CDT, leading to the remarkable reduced survival rate of breast cancer cells to 14 %. Due to the enhanced permeability and retention (EPR) effect, MFCC can retain and accumulate at the tumor site of mice for a longer period that inhibit the expression of tumor angiogenic factors, suppress tumor neovascularization, and suppress the proliferation and growth of tumor cells., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Yan Chen reports financial support was provided by Anhui Provincial Department of Education. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)- Published
- 2024
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