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The Impact of Tumor Hypoxia Modulation on sIL-2R Levels in Newly Diagnosed Diffuse Large B Cell Lymphoma (DLBCL) Patients Undergoing Chemotherapy: A Randomized Clinical Trial.
- Source :
-
Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2024 Apr 01; Vol. 25 (4), pp. 1315-1324. Date of Electronic Publication: 2024 Apr 01. - Publication Year :
- 2024
-
Abstract
- Objective: Tumor hypoxia induces the production of Hypoxia-Inducible Factor (HIF)-1 alpha, which interacts with NF-kB, leading to cancer proliferation and metastasis. This study investigated the effect of tumor hypoxia modulation using carbogen (95% O2 and 5% CO2) and nicotinamide on reducing soluble interleukin-2 receptor (sIL-2R) levels in newly diagnosed DLBCL patients with tissue overexpression of HIF-1α ≥10%.<br />Material and Methods: A prospective randomized controlled clinical trial was conducted at Dr. Kariadi Hospital in Semarang, Indonesia, from 2021 to 2022. Newly diagnosed DLBCL patients with tissue HIF-1α ≥10% were randomized into an intervention group (nicotinamide 2,000 mg + carbogen 10 liters/min during R-CHOP) and a control group (R-CHOP alone) for one cycle. sIL-2R levels were measured in the blood before and after intervention.<br />Results: The intervention group showed a significant reduction in sIL-2R levels after chemotherapy (p=0.026), with 85% of samples exhibiting a decrease. In contrast, only 45% of samples in the control group demonstrated a decrease in sIL-2R levels (p=0.184). The median sIL-2R level decreased from 139.50 pg/mL to 70.50 pg/mL in the intervention group, while the control group exhibited an increase from 182.50 pg/mL to 250.00 pg/mL following one cycle of chemotherapy.<br />Conclusion: Tumor hypoxia modulation led to a significant decrease in serum sIL-2R levels, potentially through improvements in the crosstalk between hypoxia and inflammation pathways.
- Subjects :
- Humans
Male
Female
Middle Aged
Prospective Studies
Adult
Prednisone therapeutic use
Prognosis
Rituximab therapeutic use
Follow-Up Studies
Aged
Indonesia
Hypoxia-Inducible Factor 1, alpha Subunit metabolism
Biomarkers, Tumor metabolism
Biomarkers, Tumor blood
Lymphoma, Large B-Cell, Diffuse drug therapy
Lymphoma, Large B-Cell, Diffuse pathology
Lymphoma, Large B-Cell, Diffuse metabolism
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Tumor Hypoxia drug effects
Receptors, Interleukin-2 blood
Receptors, Interleukin-2 metabolism
Vincristine therapeutic use
Doxorubicin therapeutic use
Cyclophosphamide therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 2476-762X
- Volume :
- 25
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Asian Pacific journal of cancer prevention : APJCP
- Publication Type :
- Academic Journal
- Accession number :
- 38679992
- Full Text :
- https://doi.org/10.31557/APJCP.2024.25.4.1315