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[Immunomodulation in the tumor microenvironment: Therapeutic potential of combined inhibition of tumor hypoxia and PD-1/ PD-L1].
- Source :
-
Magyar onkologia [Magy Onkol] 2024 Jul 16; Vol. 68 (2), pp. 126-135. Date of Electronic Publication: 2024 Jun 03. - Publication Year :
- 2024
-
Abstract
- Tumor hypoxia plays an important role in controlling tumor progression through signaling pathways related to the transcription factor HIF-1. In addition to enhancing migration, promoting angiogenesis and regulating metabolism, the hypoxic environment also affects immune function. In this hypoxic microenvironment an immunosuppressive milieu is established, where HIF-1 upregulates the expression of PD-L1, a key regulator of the immune response. We have found that elevated expression of PD-L1 correlates with increased HIF-1 levels in cancer cell lines and clinical samples. Thus, the co-inhibition of HIF-1 and PD-1/PD-L1 offers promising therapeutic possibilities. In this review we have examined the limitations of HIF-1 and PD-1/PD-L1 inhibition as monotherapy, explored their combined benefits and evaluated the feasibility of targeting PD-L1 with HIF-1 inhibitors.
- Subjects :
- Humans
Signal Transduction drug effects
Hypoxia-Inducible Factor 1, alpha Subunit metabolism
Tumor Microenvironment immunology
Tumor Microenvironment drug effects
B7-H1 Antigen antagonists & inhibitors
B7-H1 Antigen metabolism
Neoplasms immunology
Neoplasms drug therapy
Neoplasms pathology
Tumor Hypoxia drug effects
Programmed Cell Death 1 Receptor antagonists & inhibitors
Subjects
Details
- Language :
- Hungarian
- ISSN :
- 2060-0399
- Volume :
- 68
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Magyar onkologia
- Publication Type :
- Academic Journal
- Accession number :
- 39013086