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Your search keyword '"Escobedo, Jaime"' showing total 31 results
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31 results on '"Escobedo, Jaime"'

4. Molecular basis of USP7 inhibition by selective small-molecule inhibitors

Author

Turnbull, Andrew P., Ioannidis, Stephanos, Krajewski, Wojciech W., Pinto-Fernandez, Adan, Heride, Claire, Martin, Agnes C. L., Tonkin, Louise M., Townsend, Elizabeth C., Buker, Shane M., Lancia, David R., Caravella, Justin A., Toms, Angela V., Charlton, Thomas M., Lahdenranta, Johanna, Wilker, Erik, Follows, Bruce C., Evans, Nicola J., Stead, Lucy, Alli, Cristina, Zarayskiy, Vladislav V., Talbot, Adam C., Buckmelter, Alexandre J., Wang, Minghua, McKinnon, Crystal L., Saab, Fabienne, McGouran, Joanna F., Century, Hannah, Gersch, Malte, Pittman, Marc S., Marshall, Gary C., Raynham, Tony M., Simcox, Mary, Stewart, Lorna M. D., McLoughlin, Sheila B., Escobedo, Jaime A., Bair, Kenneth W., Dinsmore, Christopher J., Hammonds, Tim R., Kim, Sunkyu, Urbé, Sylvie, Clague, Michael J., Kessler, Benedikt M., and Komander, David

Published
2017
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6. Abstract 2652: Efficacy of a small molecule MCT1 and MCT4 transporter inhibitor in cancer

Author

Sharma, Sambad, primary, Goreczny, Gregory, additional, Bowman, Nicole, additional, Duffy, Jennifer, additional, Banerjee, Daliya, additional, Wijerathna, Sanath, additional, Dzuris, John, additional, Wu, Kerui, additional, Wu, Shih-Ying, additional, Tyagi, Abhishek, additional, Watabe, Kounosuke, additional, Escobedo, Jaime, additional, and Sandanayaka, Vincent, additional

Published
2022
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14. Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis

Author

Peters, Kevin G., Marie, Jacky, Wilson, Emily, Ives, Harlan E., Escobedo, Jaime, Del Rosario, Mercedita, Mirda, Daniel, and Williams, Lewis T.

Subjects
Fibroblast growth factors -- Research, Phosphatidylinositol -- Physiological aspects, Calcium ions -- Physiological aspects, Phospholipases -- Physiological aspects, Mutation (Biology) -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Fibroblast growth factor (FGF) receptor with a point mutation will no longer link with phospholipase C-gamma (PLC-gamma). This point mutation involves phenylalanine taking the place of tyrosine at residue 766. In addition, the mutant receptor will no longer regulate the hydrolysis of phosphatidylinositol (PtdIns) of the formation of Ca2+ following FGF stimulation. Hence the point mutation of the FGF receptor can sometimes stop activation of PLC-gamma. Moreover, FGF-induced mitogenesis can happen without Ca2+ mobilization or PtdIns hydrolysis.

Published
1992

15. Inhibition of PDGF beta receptor signal transduction by coexpression of a truncated receptor

Author

Ueno, Hikaru, Colbert, Heather, Escobedo, Jaime A., and Williams, Lewis T.

Subjects
Platelet-derived growth factor -- Research, Cellular signal transduction -- Research, Cell receptors -- Research, Science and technology, Research
Abstract

WHEN PDGF BINDS TO ITS SPECIFIC receptor on the cell surface, the receptor protein becomes phosphorylated on tyrosine residues (autophosphorylated), and the conformation of the cytoplasmic domain of the receptor [...]

Published
1991

16. Abstract 5126: Modulation of lactate in the tumor microenvironment with lactate transporter inhibitor in a melanoma syngeneic mouse model

Author

Noonepalle, Satish Kumar Reddy, primary, Kim, Jennifer, additional, Hadley, Melissa, additional, Palmer, Erica, additional, Banik, Debarati, additional, Knox, Tessa, additional, Ephrame, Sophiya, additional, Vembu, Prathima, additional, Rudish, Summer, additional, Moufarrij, Sara, additional, Escobedo, Jaime, additional, Sandanayaka, Vincent, additional, and Villagra, Alejandro, additional

Published
2018
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17. Regulation of chemotaxis by the platelet-derived growth factor receptor-beta

Author

Kundra, Vikas, Escobedo, Jaime A., Kazlauskas, Andrius, Ha Kun Kim, Sue Goo Rhee, Williams, Lewis T., and Zetter, Bruce R.

Subjects
Chemotaxis -- Research, Platelet-derived growth factor -- Observations, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The tyrosine platelet-derived growth factor receptor-beta (PDGFR-beta) balances migration-promoting and migration-suppressing activities to maintain chemotaxis toward the PDGF-BB homodimer. Specific tyrosines are mapped to reveal the mechanism involved in regulating chemotaxis. Phosphatidylinositol-3-OH kinase promotes chemotaxis in association with PDGFR-beta while Ras-GTPase-activating protein inhibits migration.

Published
1994

18. FT-1101: A Structurally Distinct Pan-BET Bromodomain Inhibitor with Activity in Preclinical Models of Hematologic Malignancies

Author

Millan, David S, primary, Alvarez Morales, Monica A, additional, Barr, Kenneth J, additional, Cardillo, Daniel, additional, Collis, Alan, additional, Dinsmore, Christopher J, additional, Escobedo, Jaime A, additional, Foley, Kevin P, additional, Herbertz, Torsten, additional, Hubbs, Stephen, additional, Kauffman, Goss S, additional, Kayser-Bricker, Katherine J, additional, Kershaw, Mark T, additional, Luke, George P, additional, Martin, Matthew W, additional, McKinnon, Crystal, additional, Mendes, Rachel L, additional, Muskiewicz, Kristina R, additional, Schiller, Shawn ER, additional, Soulard, Patricia, additional, Talbot, Adam C, additional, Walker, Duncan, additional, Yao, Lili, additional, and Williams, Grace L, additional

Published
2015
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28. Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/β-catenin signalling....

Author

Dong Yan, Wiesmann, Marion, Rohan, Michael, Chan, Vivien, Jefferson, Ann B., Lida Guo, Sakamoto, Doreen, Caothien, Roger H., Fuller, John H., Reinhard, Christoph, Garcia, Pablo D., Randazzo, Filippo M., Escobedo, Jaime, Fantl, Wendy J., and Williams, Lewis T.

Subjects
COLON cancer, NUCLEOTIDES, MESSENGER RNA, CELL lines
Abstract

Determines the activation of Wnt/beta-catenin pathway in human colon cancers. Effect of beta-catenin antisense oligodeoxynucleotides on the level of axin2 and human naked cuticle (hnkd) mRNA; Expression of axin2 and hnkd in colon cancer cell lines; Correlation of the increased expression of axin2 and hnkd with truncations in polyposis coli.

Published
2001
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29. Tightly Regulated Long-Term Erythropoietin Expression In Vivo Using Tet-Inducible Recombinant Adeno-Associated Viral Vectors

Author

Rendahl, Katherine G., Quiroz, Dulce, Ladner, Martha, Coyne, Mazie, Seltzer, Jon, Manning, William C., and Escobedo, Jaime A.

Abstract

Recombinant adeno-associated viral (rAAV) vectors containing an improved tetracycline (tet) system of transcriptional regulation are an efficient strategy for the control of long-term therapeutic gene expression. In vivo studies with the original tet-off and tet-on vectors, while promising, have failed to demonstrate complete repression in the uninduced state. To address this issue, we incorporated the tTSkid fusion of the tet repressor and a KRAB-derived transcriptional silencer into the tet-on system in the context of rAAV vectors. The tTSkid repressor and rtTA activator were expressed constituitively from a regulator vector, and the repressor and an erythropoietin (Epo) transgene were expressed inducibly via a second vector. Following intramuscular co-injection of these vectors, we observed repeated induction of serum Epo protein following drug administration and undetectable levels after its withdrawal. Four cycles of regulation were achieved over a 32-week period. Thus, the tet-on system plus the tTSkid repressor delivered via nonpathogenic rAAV vectors is a powerful tool for controlling the in vivo expression of therapeutic transgenes. In a clinical setting, the repressor could provide a mechanism for abolishing transgene expression if it were no longer needed or if the safety of a patient became compromised.

Published
2002
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30. Identification of a Domain in the Angiotensin II Type 1 Receptor Determining GqCoupling by the Use of Receptor Chimeras (∗)

Author

Wang, Caili, Jayadev, Suman, and Escobedo, Jaime A.

Abstract

The angiotensin II type 1 (AT1R) and type 2 (AT2R) receptors belong to the seven transmembrane receptor superfamily. Previous studies have suggested that the AT1R couples to a Gqsignaling pathway, whereas the AT2R does not associate with Gq. To identify the role that individual intracellular domains play in AT1R function, AT1R/AT2R chimeric receptors were prepared by substitution of intracellular loops. CHO cells expressing these chimeras were used to test angiotensin II-induced c-fosexpression and Ca2+mobilization which are involved in the AT1R signaling pathway through Gqcoupling. Substitution of the second intracellular loop (IC2) and the cytoplasmic tail between the two receptors did not affect AT1R function. However, exchange of the third intracellular loop (IC3) resulted in the loss of function in the AT1R and conferred to the AT2R the ability to constitutively activate the fospromoter. These findings suggest that the third intracellular loop of the AT1R is critical for Gqcoupling. Substitution of discrete amino acid sequences of the third intracellular loop indicate that its N-terminal and C-terminal portions, especially the seven amino acids 219-225 in the N-terminal portion, are important for AT1R function, and that the intermediate portion of this loop is not required for Gqcoupling.

Published
1995
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31. beta-Catenin regulates vascular endothelial growth factor expression in colon cancer.

Author

Easwaran V, Lee SH, Inge L, Guo L, Goldbeck C, Garrett E, Wiesmann M, Garcia PD, Fuller JH, Chan V, Randazzo F, Gundel R, Warren RS, Escobedo J, Aukerman SL, Taylor RN, and Fantl WJ

Subjects
Adenocarcinoma blood supply, Adenocarcinoma etiology, Adenocarcinoma metabolism, Adenocarcinoma pathology, Adenomatous Polyposis Coli genetics, Adenomatous Polyposis Coli metabolism, Animals, Binding Sites, Colon metabolism, Colonic Neoplasms blood supply, Colonic Neoplasms etiology, Colonic Neoplasms metabolism, Colonic Neoplasms pathology, Cytoskeletal Proteins genetics, Endothelial Growth Factors genetics, Fibroblast Growth Factor 2 analysis, Gene Expression Regulation, Neoplastic drug effects, Genes, APC, Genes, ras, Growth Substances genetics, Humans, Intercellular Signaling Peptides and Proteins genetics, Intestinal Mucosa metabolism, Lymphokines genetics, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Neoplasm Proteins genetics, Oligodeoxyribonucleotides, Antisense pharmacology, RNA, Messenger biosynthesis, RNA, Messenger genetics, RNA, Neoplasm biosynthesis, RNA, Neoplasm genetics, Recombinant Fusion Proteins physiology, Signal Transduction, Subcellular Fractions chemistry, Trans-Activators genetics, Transfection, Tumor Cells, Cultured drug effects, Tumor Cells, Cultured metabolism, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors, beta Catenin, Adenocarcinoma genetics, Colonic Neoplasms genetics, Cytoskeletal Proteins physiology, Endothelial Growth Factors biosynthesis, Gene Expression Regulation, Neoplastic physiology, Intercellular Signaling Peptides and Proteins biosynthesis, Lymphokines biosynthesis, Neoplasm Proteins biosynthesis, Promoter Regions, Genetic genetics, Trans-Activators physiology
Abstract

To evaluate whether beta-catenin signaling has a role in the regulation of angiogenesis in colon cancer, a series of angiogenesis-related gene promoters was analyzed for beta-catenin/TCF binding sites. Strikingly, the gene promoter of human vascular endothelial growth factor (VEGF, or VEGF-A) contains seven consensus binding sites for beta-catenin/TCF. Analysis of laser capture microdissected human colon cancer tissue indicated a direct correlation between up-regulation of VEGF-A expression and adenomatous polyposis coli (APC) mutational status (activation of beta-catenin signaling) in primary tumors. In metastases, this correlation was not observed. Analysis by immunohistochemistry of intestinal polyps in mice heterozygous for the multiple intestinal neoplasia gene (Min/+) at 5 months revealed an increase and redistribution of VEGF-A in proximity to those cells expressing nuclear beta-catenin with a corresponding increase in vessel density. Transfection of normal colon epithelial cells with activated beta-catenin up-regulated levels of VEGF-A mRNA and protein by 250-300%. When colon cancer cells with elevated beta-catenin levels were treated with beta-catenin antisense oligodeoxynucleotides, VEGF-A expression was reduced by more than 50%. Taken together, our observations indicate a close link between beta-catenin signaling and the regulation of VEGF-A expression in colon cancer.

Published
2003

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