Regulation of chemotaxis by the platelet-derived growth factor receptor-beta

Authors :: Kundra, Vikas
Escobedo, Jaime A.
Kazlauskas, Andrius
Ha Kun Kim
Sue Goo Rhee
Williams, Lewis T.
Zetter, Bruce R.
Source :: Nature. Feb 3, 1994, Vol. 367 Issue 6462, p474, 3 p.
Publication Year :: 1994
Abstract: The tyrosine platelet-derived growth factor receptor-beta (PDGFR-beta) balances migration-promoting and migration-suppressing activities to maintain chemotaxis toward the PDGF-BB homodimer. Specific tyrosines are mapped to reveal the mechanism involved in regulating chemotaxis. Phosphatidylinositol-3-OH kinase promotes chemotaxis in association with PDGFR-beta while Ras-GTPase-activating protein inhibits migration.