101. Chemoresistance in Ovarian Cancer: The Role of Malignant Ascites
- Author
-
Nunes M, Ricardo S, and Lele S
- Abstract
Ascites is an inflammatory process that induces the abnormal accumulation of a large amount of fluid into the peritoneal cavity. This pathological condition is observed in many neoplasms harboring peritoneal dissemination, a common feature in advanced ovarian cancer. In almost all patients, recurrent disease is accompanied by the accumulation of malignant ascites and is associated with chemoresistance and poor prognosis. The malignant ascites comprises a reservoir of a complex mixture of cellular components and soluble factors which provides a pro-inflammatory and tumor-promoting microenvironment for cancer cells. Moreover, tumor cells exhibit cancer stem-like phenotypes, acquire enhanced resistance to therapies, and higher capacity for metastatic spread and recurrent disease. The accessibility to malignant ascites and its cellular components makes it a unique source to track tumor progression and a key element to overcome chemoresistance., (Copyright: The Authors.; The authors confirm that the materials included in this chapter do not violate copyright laws. Where relevant, appropriate permissions have been obtained from the original copyright holder(s), and all original sources have been appropriately acknowledged or referenced.)
- Published
- 2022
- Full Text
- View/download PDF