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Cadmium (Cd) is an environmental and industrial pollutant that causes toxicity in various organs in humans and animals. Bee bread (perga) is a natural flavonoid with a wide range of pharmacological properties. This study was conducted to examine the effects of perga on Cd-induced nephrotoxicity. Thirty-two male Wistar rats were randomly divided into 4 groups, as the Control group, Cd group (5 mg/kg/day, orally), Perga group (0.5 g/kg/day, orally), and Cd + Perga group. At the end of the 28-day experiment, kidney tissue samples were taken and histopathological, immunohistochemical, and biochemical analyses were performed. Histopathologically, severe tubular and glomerular damage occurred as a result of Cd exposure in the Cd group. Immunohistochemically, there was an increase in caspas-3 and Bax expression in the renal tissue in the Cd group. According to the biochemical results, while the catalase, superoxide dismutase, and glutathione peroxidase antioxidant enzyme levels decreased in the Cd group, and the malondialdehyde levels increased. However, most of the above-mentioned Cd-induced changes were attenuated by treatment with perga in the Perga + Cd group. In conclusion, perga supplementation may alleviate Cd-induced renal injury through inhibition of apoptosis in renal tissue. [ABSTRACT FROM AUTHOR]

In this study, bacterial, parasitic, and fungal analyses were carried out on 15 individuals showing disease symptoms in crayfish (Pontastacus leptodactylus). Samples were collected from internal organs for pathological examinations. As a result of the pathological examinations, no parasitic and fungal pathogens agents were found. Samplings were gathered from the hepatopancreas and streaked onto tryptic soy agar (TSA) 96 and consequently, a pure bacterial colony was obtained. As a result of the bacterial tests, the bacteria were determined to be Aeromonas sp. genus. Narrow-clawed crayfish showed 100% mortality within 21 days of disease outbreak. Histopathologically, significant changes were observed in hepatopancreas and intestinal tissues. In hepatopancreatic tissue, prominent pathological findings characterized by prominent vacuolization in the epithelium, irregular tubules, proliferation of epithelial cells, nuclear pycnosis, and inflammatory cell infiltrations were detected. The findings of this study demonstrated that Aeromonas sp. caused important pathological findings in narrow-clawed crayfish. [ABSTRACT FROM AUTHOR]

Aim: Bone is a tissue in which metastasis of the primary tumor is common in oncological patients. In our study, we aimed to evaluate the clinical and pathological features and survival status of patients with histopathological bone metastases. Materials and Methods: Hematoxylin-eosin and immunohistochemical stained preparations of materials belonging to 107 patients diagnosed with metastatic tumors in bone between 2010 and 2023 in our pathology department were evaluated retrospectively. Age, gender, survival, and clinical outcomes of the patients were obtained from hospital records. Primary focus, localization of the tumor, histopathological features of the tumor, and survival status of the patients were evaluated retrospectively. Results: The ages of 107 patients ranged from 36 to 84; 61 of them were men and 46 were women. The tumor that most frequently metastasized to the bone was lung malignancy (32.7%; n=35), followed by breast malignancy (22.4%; n=24). It was determined that 35.5% of the patients (n = 38) were initially diagnosed with metastasis. Metastasis was mostly observed in the femur bone (65.4%). In the five-year survival analysis, survival was observed to be shortest (12 months) in metastasis of adenoid cystic carcinoma of the salivary gland and longest (60 months) in colorectal, prostate and thyroid tumors. Conclusion: It was determined that the most common metastasis in bone was in the femur, and rarely in atypical areas. Although metastasis was most common in adenocarcinoma morphology, it could also be in a different morphology such as carcinosarcoma. It was observed that some of the patients were initially diagnosed with metastasis and rarely the primary focus could not be determined. When evaluating tumor-containing bone materials, it should be kept in mind that metastases can present with a wide variety of localizations and morphologies. [ABSTRACT FROM AUTHOR]

Copyright of Celal Bayar Üniversitesi Saglik Bilimleri Enstitüsü Dergisi is the property of Celal Bayar University Health Sciences Institute Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This article discusses a study on high-grade serous ovarian carcinoma (HGSC) and its association with BRCA1 and BRCA2 gene mutations. The study found that HGSCs with BRCA mutations tend to exhibit certain histopathological features, such as a solid growth pattern, high mitotic activity, and prominent nuclear pleomorphism. However, there was no significant difference in the presence of tumor-infiltrating lymphocytes (TILs) or necrosis between the groups with and without mutations. The study acknowledges limitations, such as a small sample size, and suggests that further research with a larger number of cases is needed to better understand these associations. The article emphasizes the importance of pathologists in identifying cases with BRCA mutations based on tumor morphology, particularly in patients without a family history of carcinoma. [Extracted from the article]

Copyright of Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım ve Teknoloji is the property of Gazi University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Kaposi’s sarcoma (KS) is a vascular proliferation associated with Human Herpes Virus 8. Typical histopathological findings of KS are characterized by vascular proliferation, inflammatory cell infiltration, extravasated erythrocytes and spindle cell proliferation, although it varies according to the stage. In this study, the clinical-histopathological features of patients with KS were examined. The value of histopathological parameters in the diagnosis was investigated. Methods: Patients with KS diagnosed in University of Health Sciences Turkey, Samsun Training and Research Hospital Medical Pathology Department between 2016-2020 were retrospectively scanned. Clinical and tumor features and histopathological changes in the surrounding tissue were evaluated. Results: The most common histopathological features belonging to tumor were extravasated erythrocytes, spindle cell changes, fascicle formation, slit-like space; the most common epidermal features were hyperkeratosis and acanthosis; the most common peritumoral features were the presence of large vessels and ectatic vessels in the periphery. There was a significant relationship between the promontory sign and the lymphangioma-like area and ulcer. Also there was a significant relationship between nuclear atypia and lymphangioma-like area. Conclusion: While most of the histopathological features are characteristic for KS, none of them alone is specific. They should be evaluated together with all structural, tumoral and peritumoral features during the diagnostic approach. [ABSTRACT FROM AUTHOR]

Objective Doxorubicin (DOX), an anthracycline antibiotic, is a drug used in the treatment of various types of cancer. It causes damage to organs such as lung, kidney, heart, liver, brain and ovary as a result of apoptosis, inflammation, free radical formation, mitochondrial DNA damage. Agomelatine (AGO) is an agonist of the powerful antioxidant melatonin. Anti-inflammatory and antioxidant activity of AGO in heart, brain, kidney, liver and ovary tissues has been demonstrated by various studies. In this study, we aimed to determine the protective effect of AGO on the toxicity of doxorubicin in the uterine tissue. Material and Method This study was carried out on 32 rats, 8 female rats in each group. Experimental groups: Control was formed from 4 groups as DOX, DOX+AGO20 and DOX+AGO40. The rats in the control group were given 1 ml of saline (SF) once a day by oral gavage for 12 days and intraperitoneally only on the 12th day. The animals in the DOX group were given 1 ml of saline by oral gavage every day for 12 days and a single dose of 40 mg/kg DOX intraperitoneally (i.p.) on the 12th day. Animals in the DOX+AGO20 group were given 20 mg/kg AGO by oral gavage method every day for 12 days. On the 12th day, i.p. 40 mg/kg DOX was given. Animals in the DOX+AGO40 group were given 40 mg/kg AGO by oral gavage method every day for 12 days. On the 12th day, i.p. 40 mg/kg DOX was given. Results As a result of the histopathological procedures and examinations, it was observed that the damage to the uterine tissues of the DOX group was reduced in the groups that were administered DOX+ AGO20 and DOX+AGO40 combined. As a result of immunostaining (E-cadherin and eNOS), it was determined that the staining intensity was higher in the DOX group and less in the DOX+ AGO20 and DOX+AGO40 combined groups. Conslusion As a result, we think that AGO has a protective effect against the damage caused by DOX in the uterine tissue. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Agriculture & Nature / Kahramanmaraş Sütçü İmam Üniversitesi Tarım & Doğa Dergisi is the property of Kahramanmaras Sutcu Imam Universitesi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Veterinary Case Reports is the property of Ataturk University Coordinatorship of Scientific Journals and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The main focus of this study is to investigate oxidative/nitrosative stress and antioxidant effects and immunohistochemical effects in cisplatin-induced lung toxicity. In the study, 12 male Sprague Dawley rats, 2 months old, were divided into two groups: control (n=6) and cisplatin (n=6). Isotonic solution was administered to control and cisplatin 10 mg/kg single dose intraperitoneal to cisplatin group. Reducte glutathione (GSH), malondialdehyde (MDA) and nitric oxide (NO) levels were determined by spectrophotometricmethod in the lung tissues taken. Paraffin blocks were made from lung tissues and stained with hematoxylin-eosin (HE) staining. Immunohistochemically, p53, CD3, CD20, Bcl-2 ve Ki67 were evaluated. It was found that cisplatin administration alone had no effect on MDA and GSH values in the lung tissue of rats, and NO levels were significantly increased (P<0.005). In the histopathological evaluation of the lung tissue, congestion-bleeding findings, intense inflammation areas, lymphoid follicles around the bronchi and bronchioles were seen with HE staining. Concentric fibrous and fibrinous plugs consisting of blood-fibrin and inflammatory cells and fibroblasts in the airways were observed, with low- density edema between the alveoli. Reactive pan B cell markers CD20, T-cell marker CD3 in the interstitial component and desmin in sub-epithelial cells were stainedpositively by immunohistochemical staining, while reactive germinal centers Bcl-2 and p53 applied to the bronchioles and alveolarducts were immunohistochemically stained negative. In addition, low-intensity nuclear staining was found with Ki67 immunohistochemical staining.In conclusion, significant increase in NO level and immunohistochemically intense inflammation, lymphoid follicles, fibrous and fibrinous plugs are an expression of the onset of cisplatin-induced lung injury. [ABSTRACT FROM AUTHOR]

Copyright of Eurasian Journal of Veterinary Sciences is the property of Eurasian Journal of Veterinary Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Androloji Bülteni (Andrology Bullettin) is the property of BAYT Ltd. Co and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Etlik Veteriner Mikrobiyoloji Dergisi is the property of Veteriner Kontrol Merkez Arastirma Enstitusu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Etlik Veteriner Mikrobiyoloji Dergisi is the property of Veteriner Kontrol Merkez Arastirma Enstitusu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Agriculture & Nature / Kahramanmaraş Sütçü İmam Üniversitesi Tarım & Doğa Dergisi is the property of Kahramanmaras Sutcu Imam Universitesi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Agriculture & Nature / Kahramanmaraş Sütçü İmam Üniversitesi Tarım & Doğa Dergisi is the property of Kahramanmaras Sutcu Imam Universitesi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Duzce University Journal of Science & Technology is the property of Duzce University Journal of Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Ege Journal of Fisheries & Aquatic Sciences (EgeJFAS) / Su Ürünleri Dergisi is the property of Ege Journal of Fisheries & Aquatic Sciences (EgeJFAS) / Su Urunleri Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Mesane kanserinin (BC) erken teşhisi, hastalığın tedavisi ve seyri için büyük önem taşımaktadır. Teşhis için en etkili yöntem, çeşitli işlemlerin uygulandığı doku örneğinin patolog tarafından mikroskop altında incelenmesidir. Ancak bu yaklaşım subjektiftir ve patologların bilgi ve tecrübesine bağlı olarak değişebilir. Objektifliği artırmak ve patoloğa yardımcı olmak için bu çalışma, tam slayt görüntülerinden (WSI) otomatik mesane ürotelyal karsinom derecelendirmesini sunar. Naive Bayes, k en yakın komşu ve karar ağacı gibi 3 farklı makine öğrenme yöntemi kullanılarak performans karşılaştırması yapılır. Deneysel sonuçlar, karar ağacı yönteminin %82 ile en yüksek performansı elde ettiğini ve tanı sırasında patoloğa yardımcı olmak için kullanılabileceğini göstermektedir.

Copyright of Journal of Agriculture & Nature / Kahramanmaraş Sütçü İmam Üniversitesi Tarım & Doğa Dergisi is the property of Kahramanmaras Sutcu Imam Universitesi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Uludag University Medical Faculty / Uludağ Üniversitesi Tıp Fakültesi Dergisi is the property of Journal of Uludag University Medical Faculty and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Kocatepe Veterinary Journal / Kocatepe Veteriner Dergisi is the property of Afyon Kocatepe University, Faculty of Veterinary Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: The purpose of this study was to investigate the effects of differing doses of resveratrol (RES) against cisplatin (CP)-induced gastrointestinal injury in small intestinal tissue using histopathological and immunohistochemical methods. Materials and Methods: Forty-eight healthy male Wistar albino rats aged 12-16 weeks were divided into eight groups, control RES-30, RES-60, RES-90, CP, CP+RES30, CP+RES60, and CP+RES90. Small intestine tissues were collected at the end of the experimental period and subjected to routine Hematoxylin & Eosin (H&E) and Periodic Acid Schiff (PAS) staining. Tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) were evaluated from immunohistochemically stained tissues. DNA fragmentation was evaluated using the TUNEL technique. Results: Based on the histopathological findings, vacuolization and shedding were observed in the small intestine surface epithelium with notable fusion and shortening in the villus structure in the CP group. Significant decreases were observed in the CP+RES30, CP+RES60, and particularly CP+RES90 groups compared to the CP group in terms of apical surface epithelial degeneration, villous fusion, and inflammatory cell infiltration. The apoptotic index (AI) and TNF-α immunoreactivities were significantly higher in the CP group (p<0.05). AI and TNF-α immune intensity were significantly lower in the treatment groups (p<0.05). It has been determined that among the treatment groups, particularly the CP+RES30 group showed the lowest damage score values and immunoreactivity of TNF-α with AI.Conclusions: CP caused severe histological tissue injury, intestinal apoptosis, and proinflammatory cytokine release, while RES administered before CP treatment exhibited a dose-dependent protective effect (particularly at RES30 mg/kg) against CP-induced intestinal injury. [ABSTRACT FROM AUTHOR]

Objective: Long-term complications of cesarean delivery are numerous and are increasing due to the high cesarean rate. The long-term complications are attributed to the different suturing methods. The single-layer locked (SLL) and double-layer unlocked (DLU) are the most compared. This study aims to compare the early histopathological properties of these two suture techniques in an experimental animal study. Material and Method: Ten pregnant Wistar-Albino rats had cesarean at term. The right uterine horns were repaired using the SLL suture technique, and the left ones were repaired using the DLU technique. The control subjects were the six uterine horns of three pregnant rats delivered vaginally. Each animal underwent a hysterectomy on day 15 of pregnancy, and each uterus was an experimental unit. The mean thickness of the endometrium and myometrium of the intervention groups with histopathological features and controls were compared. Result: In SLL and DLU groups, the endometrium (276.6±123.1 vs. 258.4±125.9 μm; p=0.748) and myometrium (531.7±189.2 vs. 505.9±182.1 μm; p=0.612) in scarred areas were similar. In nonscarred areas, the endometrium was measured as 239.9±68.9, 256.5±127.2, and 316.4±98.6 μm in SLL, DLU, and control group, respectively (p=0.347). The myometrium of non-scarred areas was also similar in all groups evaluated (387.2±119.9; 364.5±154.1 and 234.0±49.1 μm; p=0.265). The histopathological features of uteri repaired with two different techniques were also similar. Conclusion: The early histopathological properties of all uteri examined were similar after repairing with SLL or DLU techniques. These results indicate that the repair process does not differ in the early stages, regardless of the uterine closure technique used. [ABSTRACT FROM AUTHOR]

This study examines the histopathological changes in pulp tissue of teeth in periodontitis patients with deep pockets but no root damage. The study includes 68 teeth from 33 individuals diagnosed with stage 3 and 4 periodontitis (degree B and C) through clinical examination, periodontal assessment, and periapical radiography. The BRD criteria (Bacterial Invasion, Regenerative Parameters, and Degenerative Parameters) were used to evaluate sections (5μm). Participant demographics and histological parameters were expressed as percentages. Median periodontal values were presented, and Pearson's Correlation was analyzed. The study compared periodontal parameters with pulp histopathological data using a significance threshold of P<0.05. Of the patients who underwent extractions, 19 were female and 15 were male, with a mean age of 49.12±7.17 years (ranging from 18 to 65 years). All teeth had a mobility degree of three. There were 33 incisors and 35 single-rooted premolars. Degenerative parameters were observed in 95.6% of teeth, while regenerative parameters were observed in 47%.Bacterial invasion was observed in 5% of teeth. The study results suggest a relationship between pulp degeneration and the severity of periodontal disease. Pulp sensitivity had a moderately positive correlation with the severity of periodontal disease. A significant correlation was found between Clinical Attachment Level (CAL), which indicates the severity of periodontal destruction, and pulpal inflammation (rho=0.384 and P<0.05). Within the limits of this study, advanced periodontal disease has both regenerative and degenerative effects on the pulp. Therefore, when diagnosing and planning treatment for patients with advanced periodontitis, it is important to consider the presence of endodontic-periodontal lesions. It is also important to note that changes in the pulp of still vital teeth due to periodontal destruction can have an impact on the outcomes of periodontal treatment. [ABSTRACT FROM AUTHOR]

This study was conducted to identify the disease that caused mortality in rainbow trout (Oncorhynchus mykiss) farms in the Aegean and Mediterranean regions in March 2022. External examination of infected trout revealed bilateral exophthalmos, hemorrhage in the lower jaw, dropsy, anemia in the liver, yellow exudate accumulation in the digestive system, hemorrhage in the adipose tissue and anus area, and spleen enlargement. A Gram-positive bacterium, Staphylococcus warneri, was isolated from infected fish's liver and anterior kidney. S. warneri was identified using morphological features, some conventional biochemical tests, and molecular genetic methods utilizing the 16S rRNA and sodA gene regions. Histopathological examination showed infiltration in the liver tissue, hyperemia in the spleen tissue, and necrotic changes in the kidney tubular epithelium of infected fish. According to the disk diffusion method, doxycycline was determined to be the most sensitive antibiotic against the S. warneri isolate. Although S. warneri was isolated in previous studies on rainbow trout, its histopathological effects on organs were determined for the first time in this study. [ABSTRACT FROM AUTHOR]

Copyright of Harran University Journal of the Faculty of Veterinary Medicine / Harran Üniversitesi Veteriner Fakültesi Dergisi is the property of Harran University, Faculty of Veterinary Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Harran University Journal of the Faculty of Veterinary Medicine / Harran Üniversitesi Veteriner Fakültesi Dergisi is the property of Harran University, Faculty of Veterinary Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Pamukkale Medical Journal is the property of Pamukkale Journal of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Eurasian Journal of Veterinary Sciences is the property of Eurasian Journal of Veterinary Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of MN Opthalmology / MN Oftalmoloji is the property of Medical Network and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In this study, the histopathological diagnosis and treatment of an intermuscular lipoma were reported in a dog. In the clinical inspection, there was a large mass in the caudal of the left femur and that the animal had difficulty in moving. On palpation, the mass was solid and painful. A decision was made to totally extirpate the mass, which was suspected to be a tumor. A wide skin incision was made from the caudal part of the left femur; the mass was separated from the surrounding tissues by blunt dissection and extirpated. Histopathological examination revealed that the mass was an intermuscular lipoma. In the postoperative period, the patient recovered completely and returned to its normal life. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Faculty of Pharmacy of Ankara University / Ankara Üniversitesi Eczacilik Fakültesi Dergisi is the property of Ankara University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Innovations such as the widespread use of motorized microscopes, the automatic scanning of the tissue taken from the patient and transferring it to a single large image, and the production of deep/adversarial networks specific to segmentation have increased the hope of automatically producing outputs very close to expert labeling in the segmentation problem. Particularly, it is known that segmentation performances are improved by integrating attention modules into classical 3D-UNet or GAN architectures. In this study, the effects of four different attention modules (DAF, DAF3D, DANet and MSA) were analyzed in solving the histopathological image segmentation problem. While single (SLF) and multiple (MLF) layer features are used together in DAF and DAF3D modules, two different mechanisms, position attention module and channel attention module, are used in DANet and MSA modules. As a result of the experimental studies, it has been seen that the DAF3D attention module maximizes the segmentation accuracy (0.76 mIoU and 0.89 PA). At the same time, the method with the lowest segmentation cost (0.156 seconds for 1 image) among the approaches was again DAF3D. [ABSTRACT FROM AUTHOR]

Cadmium, which is one of the toxic metals widely used in many areas of the world, is taken into the body in different ways. In this study, the damage caused by cadmium in the brain and how this damage affects the levels of glial fibrial acidic protein, 8-Oxo-2'-deoxyguanosine (8-OHdG), neuronal nitric oxide synthase, Süperoksit dismutaz (SOD), Glutatyon (GSH), glutatyon peroksidaz (GPX), inducible nitric oxide synthase, and malondialdehid (MDA) expression in the brain tissue were investigated. A total of 16 male Wistar albino rats 200-220 g were used in the experimental study. Rats were divided into 2 groups. A single cadmium i.p. dose of 0.025 mmol/kg was given to rats in the cadmium group. Rat brain tissue samples were analyzed using biochemical analyses as well as histopathological and immunohistochemical methods. In the histopathological examination of the brain tissues, normal histological structure was observed in the brain samples belonging to the control group, while necrosis and degeneration of neurons in the brain, as well as hyperemia in the parenchyma and meningeal vessels were observed in the cadmium group. In immunohistochemical examinations, while glial fibrial acidic protein, 8-OHdG, and neuronal nitric oxide synthase expression was not observed in the brain samples of control group, severe expression of glial fibrial acidic protein, 8-OHdG, and neuronal nitric oxide synthase was observed in the brain tissue of the group receiving cadmium. In the biochemical analyses performed, it was observed that SOD, GSH, and GPx enzyme levels increased in cadmium groups, inducible nitric oxide synthase and MDA enzyme levels were decreased. As a result of this study, it is thought that markers' expression levels are important in understanding the oxidative stress in pathogenesis of cadmium toxicity and will provide a guide and important contributions to future studies. [ABSTRACT FROM AUTHOR]

Copyright of Gazi Üniversitesi Fen Bilimleri Dergisi Part C: Tasarım ve Teknoloji is the property of Gazi University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Purpose: The primary aim of thşis study was to evaluate difference in the number of patients with tru-cut biopsies to diagnose breast lesions between non-pandemic and pandemic periods. Materials and Methods: In this study, the nonpandemic period and the pandemic period were compared, the periods for the pandemic times, between March 1, 2018, and 29 February 2020, and for the nonpandemic period, 1 March 2020 to 12 March 2022 to 12 March 2022. In each period, we have included all the tru-cut biopsies for suspected breast cancer. During the pandemic and non-pandemic period, the number of tru-cut biopsies BI-RADS and histopathological findings of the patients who experienced tru-cut biopsies were compared. Results: The number of tru-cut biopsies performed during the nonpandemic and pandemic period was similar (1596, 1599). In the pandemic period, tru-cut biopsy histopathologic reports revealed that benign and high-risk cases decreased statistically, while invasive carcinoma cases increased by 1.9 (95% CI 1.6-2.2) times. During the pandemic period, US-guided BI-RADS 3 and BI-RADS 4a cases decreased statistically significantly, BBI-RADS 4b cases increased 1.4 (95% CI 1.1-2.2) times, BI-RADS 4c cases 1.7 (95% CI 1.2-2.2), BI-RADS 5 cases increased 2.1 (95% CI 1.4-3.1) times Conclusion: There was no significant change in tru-cut biopsy numbers compared to the period of the pandemic and the non-pandemic period. However, the stage of the cancers captured during the period of the pandemic was higher.

Objectives: Veneral Disease Research Laboratory (VDRL) test is an important screening tool for syphilis in pregnancy (because of adverse pregnancy outcomes, particularly congenital syphilis {CS}) and can be combined with the placental histopathological examination in the diagnosis of CS. Thus, we aimed to compare VDRL test results from HIV-positive/HIV-negative pregnant women with relevant historical data and perinatal/placental histopathological findings. Methods: A prospective hospital-based cross-sectional survey of VDRL tests for two study groups (HIV-positive {tests} and HIVnegative {controls} pregnant women) at ante-natal care (ANC)/delivery. A convenient sampling method was used. Relevant (maternal/fetal) historical data were extracted from their case notes, and placentas of reactive VDRL cases were histopathologically examined. Results: We surveyed 145 pregnant women (49 tests and 96 controls). The VDRL tests, for both groups, were not strongly associated with maternal age (p-value = 0.097), booking for ANC (p-value = 0.770), gravidity (p-value = 0.331), and HIV/AIDS stage (for tests only). Notably, one subject from the tests had a reactive VDRL test, and she was in HIV/AIDS clinical stage 2, her baby had microcephaly (fetal head circumference of 31 cm), low birth weight (of 2.4 kilograms), and intermediate APGAR score. Histopathological examination of her placenta showed avascular villi, large hypercellular villi, and obliterative vasculopathy with an onion-skinning pattern in the placental disk. Conclusions: The obstetrical, fetal, and placental histopathological features of the reactive VDRL case were consistent with CS and syphilitic placentitis. Hence placental histopathological evaluation can play a critical role in the diagnosis of maternal/congenital syphilis. [ABSTRACT FROM AUTHOR]

Copyright of Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Amaç: Şırnak’ta yapılan üst gastrointestinal endoskopi bulguları ve histopatoloji sonuçlarının değerlendirilerek, saptanan bulguların sıklığının belirlenmesi ve literatür verileri ile karşılaştırarak, bölgesel farklılıkların gösterilmesi amaçlanmıştır. Gereç ve Yöntemler: Ekim 2019 ve Ağustos 2021 tarihleri arasında Şırnak Devlet Hastanesi gastroenteroloji kliniği endoskopi ünitesinde yapılan üst gastrointestinal endoskopi raporları ve histopatoloji sonuçları hastane online datası ve hasta dosyalarından retrospektif olarak tarandı. Endikasyon nedenleri, endoskopik bulgular, histopatopatoloji sonuçları, hastaların demografik özelikleri kayıt altına alınarak SPPS 25 istatistik programı yardımı ile analiz edildi. Bulgular: Çalışmaya alınan 1842 hastanın %51 (n:940)’ i erkek; yaş ortalaması 42,57±18,14 (dağılım 18-120) yıl idi ve bu hastaların %70,1 (n:1292)’ inden biyopsi alındı. En sık endikasyon dispepsi ve reflü semptomları (%63,9) idi. En sık rastlanan bulgular özofagusta özofajit (%39,8), midede eritemli/antral gastrit (%63,1) ve duodenumda duodenit (%14,3) idi. Üst gastrointestinal sistem kanseri, Barrett özofagusu, üst gastrointestinal sistem polibi, çölyak hastalığı sıklıkları, sırasıyla, %2,2 (n:40), %0,8 (n: 14); %3,3 (n:61); % 1,1 (n:20) idi. Helicobacter pylori, kronik inflamasyon, nötrofil aktivitesi, glandüler atrofi ve intestinal metaplazi sıklığı sırasıyla, %63,8, %86,1, %64,7, %4,2 ve %6,6 idi. 5 (%0,4) hastada endoskopi ve biyopsi bulguları otoimmun gastrit ile uyumlu saptandı. Sonuç: Bu çalışma ile Şırnak ilinde üst gastrointestinal endoskopi ve patoloji verileri, bilindiği kadarıyla, ilk kez ve güncel olarak değerlendirildi. Bulguların sıklığında zamanla değişim olduğu ve bölgesel farklılıklar olduğu tespit edildi. Bu bulguların gelecekte yapılacak epidemiyolojik çalışmalara katkı sağlayacağı düşünülmektedir.

Copyright of Journal of Agriculture & Nature / Kahramanmaraş Sütçü İmam Üniversitesi Tarım & Doğa Dergisi is the property of Kahramanmaras Sutcu Imam Universitesi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In this study, the protective effects of Vit. C and E on the histopathological changes, antioxidant enzyme activities and changes in malondialdehyde (MDA) levels that can be caused by a carbamate pesticide bendiocarb (BND) in testicular tissue of rats were investigated. Rats were divided into eight groups: group 1 controls; group 2 Vit. C (100 mg kg-1 day-1); group 3 Vit E (100 mg kg-1 day-1); group 4 Vit C plus E; group 5 bendiocarb (0.8 mg kg-1 day-1); group 6 BND and Vit. C; group 7 BND and Vit. E; and group 8 BND and vitamin C and E. After 28 days of treated, when the bendiocarb treated group was compared to the control group, an increase in the MDA level was observed in the testicular tissues of the rats, while antioxidant enzyme activities [superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPx)] a statistically significant decrease in was observed. In histopathological examinations, it was determined that vitamin C and E decreased the pathological changes caused by BND in the testicular tissue of rats. [ABSTRACT FROM AUTHOR]

Copyright of Etlik Veteriner Mikrobiyoloji Dergisi is the property of Veteriner Kontrol Merkez Arastirma Enstitusu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Purpose: This study aimed to evaluate the relationship between strain elastography and immunohistochemical markers, the histologic grade, and molecular subtyping in invasive breast cancer. Materials and Methods: The relationships between the elastography index values and progesterone receptor, estrogen receptor, human epidermal growth factor receptor 2, Ki-67, the histologic grade, and molecular subtype in 171 patients who had not received neoadjuvant treatment and underwent breast-conserving surgery were evaluated. Strain elastosonography were used to evaluate elastography index. Results: The mean patient age was 46.871 ± 11.949 years. There were 135, 129, and 90 estrogen receptor-positive, progesterone receptor-positive, and human epidermal growth factor receptor 2-positive patients, respectively. Forty-seven patients had the worst histological grade. Based on molecular subtyping, human epidermal growth factor receptor 2-positive, luminal A, luminal B, and triplenegative classifications were made for 25 (14.5%), 29 (17.0%), 109 (63.7%), and 8 (4.7%) cases, respectively. There was no statistically significant correlation between the elastography index values and estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67, histologic grade, or molecular subtype among these breast resection cases. Conclusion: The elastography index value was insufficient to predict the specified histopathological parameters. [ABSTRACT FROM AUTHOR]

Intraabdominal adhesions are an important health problem that is seen in the postoperative period and negatively affects the quality of life. Chemical and thermal factors that occur in the peritoneal cavity and serosal surfaces, causing abdominal trauma, or infection and foreign body reactions may cause adhesion formation. Although the classification of intraabdominal adhesions is generally based on adhesion density and severity of prognosis, there is not yet a worldwide accepted standard classification system. Intraabdominal adhesions show clinical reflections with negative consequences such as pain, infertility, prolonged hospital stay after surgery and economic burden. In conclusion, adhesions encountered in the postoperative period are a serious problem and further studies should be adapted from laboratory environment to clinical research models in order to prevent adhesion formation. This review was prepared to review the literature on intraabdominal adhesion formation, histopathology, grading, prevention and clinical significance. [ABSTRACT FROM AUTHOR]

Copyright of MN Opthalmology / MN Oftalmoloji is the property of Medical Network and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Kanser tedavisinde kullanılan ilaçların etkileri yalnızca kanser hücrelerine özgü olmayıp sağlıklı hücreleri de olumsuz etkilemektedir. Bu çalışmada antikanser bir ilaç olan paklitaksel’in (PAX) böbrek dokusundaki olası zararlı etkilerine karşı antioksidan etkileriyle öne çıkan silimarin’in (SLY) olası koruyucu etkilerinin ortaya konulması amaçlandı. Toplam 28 adet Sprague-Dawley cinsi dişi sıçandan rastgele bir seçimle: Kontrol, PAX, SLY ve PAX + SLY olmak üzere dört grup (n=7) oluşturuldu. PAX grubuna 2 mg/kg intraperitoneal yolla PAX, SLY grubuna oral gavaj sonda ile 100 mg/kg SLY, PAX + SLY grubuna ise önceki gruplarla aynı doz ve yolla PAX ve SLY uygulandı. Deneysel işlemlerin sonunda hayvanlardan alınan kan ve böbrek dokularında yapılan biyokimyasal analizlerde PAX’ın, böbrek dokusunda oksidatif stresi, serumda ise kreatinin (Cr) ve kan üre azotu (blood urea nitrogen, BUN) seviyelerini artırdığı tespit edildi. Böbrek dokusunda yapılan histopatolojik incelemelerde PAX’ın renal korpüskül atrofisi, fırçamsı kenarda hasar, vakuolar dejenerasyon ve deskuamasyon gibi patolojik değişikliklere yol açtığı gözlendi. Antienflamatuar, antiapoptotik ve antioksidan etkilere sahip bir farmakolojik ajan olan SLY uygulanması ise, PAX kullanımı sonucu meydana bu gelen patolojik değişiklikleri büyük oranda engelledi. Mevcut çalışmada elde edilen sonuçlar PAX ile yapılacak tedavilerde böbrek dokusunda şekillenecek zararlı etkilere karşı koruyucu olarak SLY’nin kullanılabileceğini gösterdi.

Encephalitic listeriosis is the most significant purulent encephalitis in ruminants and is a very common endemic problem in sheep, cattle, and goats. In this study, it was aimed to compare the presence of Listeria (L.) monocytogenes revealed by immunohistochemical (IHC) and Real-Time PCR methods with histopathological findings obtained from the archive materials. The study material consisted of pons and medulla oblongata paraffin tissue of 100 ruminants (9 cattle, 4 calves, 44 sheep, 38 lambs, and 5 goats). Positivity was obtained by the IHC method in 46 (46%) and by the Real-Time PCR method in 21 (21%) of 100 cases. In the L. monocytogenesis antigen IHC scoring, more severe staining was observed in sheep and goats (P>0.05). In the IHC positive cases, microabscess was more severe in sheep and goats than in cattle and lambs (P<0.05). In addition, 19 patients had Coenurus cerebralis cysts, and 3 of them were found to be positive for the IHC agent of Listeria. It was concluded that IHC and PCR methods can be used to detect L. monocytogenes from paraffin blocks, but the IHC method is a more effective method than PCR in revealing the presence of antigen from paraffin blocks stored for many years. [ABSTRACT FROM AUTHOR]

Copyright of Eurasian Journal of Veterinary Sciences is the property of Eurasian Journal of Veterinary Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)