1. Clinicopathological features of myofibromas and myofibromatosis affecting the oral and maxillofacial region: A systematic review.
- Author
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Silveira, Felipe Martins, Kirschnick, Laura Borges, Só, Bruna Barcelos, Schuch, Lauren Frenzel, Pereira Prado, Vanesa, Sicco, Estefania, Lima, Rafael Rodrigues, Bologna‐Molina, Ronell Eduardo, Mosqueda‐Taylor, Adalberto, Vasconcelos, Ana Carolina Uchoa, and Martins, Manoela Domingues
- Subjects
BENIGN tumors ,CLINICAL pathology ,GREY literature ,SMOOTH muscle ,ELECTRONIC information resource searching ,FACIAL injuries ,MANDIBULAR fractures - Abstract
Background: Myofibromas are rare benign neoplasms composed of myoid cells and myofibroblasts. This study aimed to systematically review case reports and a series of myofibromas (MF) and myofibromatosis (MFT) occurring in the oral and maxillofacial regions in order to describe their main clinicopathological features. Methods: This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. Electronic searches were conducted in 2023 in four databases: MEDLINE/PubMed, Web of Science, Scopus, and EMBASE. A manual search and a search in the grey literature were also conducted. The lesions were classified as MF or MFT according to their original report. Results: A total of 169 cases were included in this systematic review. Men were slightly more affected, with a painless nodule. When occurring in soft tissue, MF usually developed in the gingiva (mean age:29.23 ± 21.93 years) and when it was intra‐osseous, it occurred more frequently in the posterior mandible (mean age:14.33 ± 15.62 years). MFT occurred mainly in the mandible and was predominantly described as well‐circumscribed masses of spindle cells organized in fascicles with a prominent vascular activity in a hemangiopericytoma‐like pattern. The lesions were mainly positive for smooth muscle actin and vimentin immunomarkers. Surgical excision was the treatment of choice in the majority of cases and recurrence was observed in only three cases. Conclusion: MF and MFT affect more men, with an indolent clinical course. Intra‐osseous tumors and MFT seem to occur more frequently in younger individuals. These lesions seem to have a good prognosis and low recurrence. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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