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Immunohistochemical expression of cyclooxygenase-2 (COX-2) in oral nevi and melanoma.
- Source :
-
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2016 Jul; Vol. 45 (6), pp. 440-3. Date of Electronic Publication: 2015 Nov 26. - Publication Year :
- 2016
-
Abstract
- Background: Cyclooxygenase-2 (COX-2) catalyses the conversion of arachidonic acid to prostaglandin, and its overexpression has been demonstrated in different malignant tumors, including cutaneous melanoma. However, no data about the expression of this protein in oral melanocytic lesions are available to date. The aim of this study was to evaluate the immunohistochemical expression of COX-2 in oral nevi and melanomas, comparing the results with correspondent cutaneous lesions.<br />Methods: COX-2 was evaluated by immunohistochemistry in 49 oral melanocytic lesions, including 36 intramucosal nevi and 13 primary oral melanomas, and in four cutaneous nevi and eight melanomas.<br />Results: All cases of oral and cutaneous melanomas were positive for COX-2. On the other hand, all oral and cutaneous melanocytic nevi were negative.<br />Conclusion: COX-2 is highly positive in oral melanomas and negative in oral nevi and might represent a useful marker to distinguish melanocytic lesions of the oral cavity.<br /> (© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor biosynthesis
Female
Humans
Immunohistochemistry
Melanocytes enzymology
Melanocytes pathology
Melanoma diagnostic imaging
Melanoma pathology
Middle Aged
Mouth Mucosa diagnostic imaging
Mouth Mucosa enzymology
Mouth Mucosa pathology
Mouth Neoplasms diagnostic imaging
Mouth Neoplasms pathology
Nevus diagnostic imaging
Nevus pathology
Skin Neoplasms diagnostic imaging
Skin Neoplasms pathology
Young Adult
Melanoma, Cutaneous Malignant
Cyclooxygenase 2 biosynthesis
Melanoma enzymology
Mouth Neoplasms enzymology
Nevus enzymology
Skin Neoplasms enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0714
- Volume :
- 45
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 26608958
- Full Text :
- https://doi.org/10.1111/jop.12385