13 results on '"Yunsheng Xu"'
Search Results
2. HPV E6 promotes cell proliferation of cervical cancer cell by accelerating accumulation of RBM15 dependently of autophagy inhibition
- Author
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Gang Nie, Bo Tang, Mingfen Lv, Danyang Li, Tian Li, Rongying Ou, Yunsheng Xu, and Juan Wen
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Cell Biology ,General Medicine - Published
- 2023
3. An Enzyme‐Engineered Nonporous Copper(I) Coordination Polymer Nanoplatform for Cuproptosis‐Based Synergistic Cancer Therapy
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Yuzhi Xu, Si‐Yang Liu, Leli Zeng, Hansu Ma, Yanfei Zhang, Huihui Yang, Yuchen Liu, Shuo Fang, Jing Zhao, Yunsheng Xu, Charles R. Ashby, Yulong He, Zong Dai, and Yihang Pan
- Subjects
Polymers ,Mechanical Engineering ,Hydrogen Peroxide ,Glutathione ,Mitochondrial Proteins ,Mice ,Glucose Oxidase ,Glucose ,Mechanics of Materials ,Neoplasms ,Cell Line, Tumor ,Animals ,Nanoparticles ,General Materials Science ,Copper - Abstract
Cuproptosis, a newly identified form of regulated cell death that is copper-dependent, offers great opportunities for exploring the use of copper-based nanomaterials inducing cuproptosis for cancer treatment. Here, a glucose oxidase (GOx)-engineered nonporous copper(I) 1,2,4-triazolate ([Cu(tz)]) coordination polymer (CP) nanoplatform, denoted as GOx@[Cu(tz)], for starvation-augmented cuproptosis and photodynamic synergistic therapy is developed. Importantly, the catalytic activity of GOx is shielded in the nonporous scaffold but can be "turned on" for efficient glucose depletion only upon glutathione (GSH) stimulation in cancer cells, thereby proceeding cancer starvation therapy. The depletion of glucose and GSH sensitizes cancer cells to the GOx@[Cu(tz)]-mediated cuproptosis, producing aggregation of lipoylated mitochondrial proteins, the target of copper-induced toxicity. The increased intracellular hydrogen peroxide (H
- Published
- 2023
4. Knockdown of circular RNA VANGL1 inhibits TGF‐β‐induced epithelial‐mesenchymal transition in melanoma cells by sponging miR‐150‐5p
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Shaolong Leng, Jin Wu, Chongchao Hou, Yunsheng Xu, Laiming Mo, Xue Xie, Hongfeng Zhou, and Ling Wang
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Epithelial-Mesenchymal Transition ,Skin Neoplasms ,Apoptosis ,Cell Movement ,Transforming Growth Factor beta ,Circular RNA ,Cell Line, Tumor ,miR-150 ,miR‐150‐5p ,melanoma ,medicine ,Humans ,circular RNA VANGL1 ,Epithelial–mesenchymal transition ,neoplasms ,Cell Proliferation ,TGF‐β ,Gene knockdown ,Chemistry ,Melanoma ,EMT ,Membrane Proteins ,RNA, Circular ,Original Articles ,Cell Biology ,medicine.disease ,Up-Regulation ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,Cell culture ,Direct binding ,Cancer research ,Molecular Medicine ,RNA, Long Noncoding ,Original Article ,Carrier Proteins ,Transforming growth factor - Abstract
Melanoma is one of the most aggressive and life‐threatening skin cancers, and in this research, we aimed to explore the functional role of circular RNA VANGL1 (circVANGL1) in melanoma progression. The expression levels of circVANGL1 were observed to be significantly increased in clinical melanoma tissues and cell lines. Moreover, circVANGL1 knockdown suppressed, while circVANGL1 overexpression promoted the proliferation, migration and invasion abilities of melanoma cells. Further investigations confirmed the direct binding relation between circVANGL1 and miR‐150‐5p in melanoma, and restoration of miR‐150‐5p blocked the effects of circVANGL1 overexpression in melanoma cells. We further found that circVANGL1 was up‐regulated by TGF‐β treatment, and the enhanced EMT of TGF‐β‐treated melanoma cells was blocked by circVANGL1 knockdown. In conclusion, these results indicated that circVANGL1 might serve as a promising therapeutic target for melanoma.
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- 2021
5. Correlation between structural evolution and rheological properties for polycarbonate in the molten state
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Mengdi Chen, Mingfu Zheng, Lu Zhang, Yunsheng Xu, Xianming Zhang, and Wenxing Chen
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Polymers and Plastics ,Materials Chemistry ,General Chemistry ,Surfaces, Coatings and Films - Published
- 2022
6. Comparative metabolomic and transcriptomic analyses revealed the differential accumulation of secondary metabolites during the ripening process of acerola cherry ( <scp> Malpighia emarginata </scp> ) fruit
- Author
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Mingfeng Xu, Chenjia Shen, Changfeng Xue, Yunsheng Xu, Jiangning Hu, Qin Zhu, and Beiwei Zhu
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Chalcone synthase ,food.ingredient ,Flavonoid ,Ascorbic Acid ,Biology ,Antioxidants ,food ,Metabolomics ,Gene Expression Regulation, Plant ,Food science ,Carotenoid ,chemistry.chemical_classification ,Nutrition and Dietetics ,food and beverages ,Fatty acid ,Ripening ,Metabolic pathway ,chemistry ,Fruit ,Malpighia emarginata ,biology.protein ,Transcriptome ,Agronomy and Crop Science ,Malpighiaceae ,Food Science ,Biotechnology - Abstract
Background Acerola cherry is a famous functional fruit containing plentiful antioxidants and other nutrients. However, studies on the variations among nutrients during the ripening process of acerola fruit are scare. Results Comparative metabolomic and transcriptomic analyses were performed and identified 31 331 unigenes and 1896 annotated metabolite features in acerola cherry fruit. K Kyoto Encyclopedia of Genes and Genomes enrichment analysis showed that several antioxidant and nutrient-related metabolic pathways, such as the flavonoids, vitamins, carotenoids, amino acids, and fatty acids metabolic pathways, were significantly changed during the ripening process. The metabolites related to the vitamin, carotenoid, and fatty acid metabolic pathways were downregulated during the ripening process. Several flavonoid biosynthesis-related genes (including dihydroflavonol 4-reductase, chalcone synthase, flavanone 3-hydroxylase, and anthocyanidin synthase), were significantly upregulated, suggesting their essential functions in the accumulation of flavonoids in mature fruit. Conclusion Most of the vitamin and carotenoid metabolism-related metabolites significantly accumulated in immature fruit, suggesting that immature acerola fruit is a good material for the extraction of vitamins and carotenoids. For macronutrients, most of the amino acids accumulated in mature fruit and most of the fatty acids greatly accumulated in immature fruit. Our data revealed the differential accumulation of antioxidants and nutrients during the ripening process of acerola cherry fruit. © 2021 Society of Chemical Industry.
- Published
- 2021
7. Functional properties of gonad protein isolates from three species of sea urchin: a comparative study
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Yunsheng Xu, Hai-Tao Wu, Jia-Run Han, Xiao-Fan Cui, Changfeng Xue, Tie-Tao Zhang, Yi-Nan Du, Jia-Nan Yan, Sheng-Yi Su, Wen-Hui Shang, and Beiwei Zhu
- Subjects
Gonad ,030309 nutrition & dietetics ,03 medical and health sciences ,chemistry.chemical_compound ,0404 agricultural biotechnology ,biology.animal ,medicine ,Animals ,Denaturation (biochemistry) ,Food science ,Sodium dodecyl sulfate ,Gonads ,Polyacrylamide gel electrophoresis ,Sea urchin ,Essential amino acid ,Strongylocentrotus ,chemistry.chemical_classification ,0303 health sciences ,biology ,urogenital system ,Proteins ,04 agricultural and veterinary sciences ,040401 food science ,Amino acid ,Isoelectric point ,medicine.anatomical_structure ,chemistry ,Sea Urchins ,Food Science - Abstract
Sea urchin Mesocentrotus nudus, Glyptocidaris crenularis, and Strongylocentrotus intermedius gonad protein isolates (mnGPIs, gcGPIs, and siGPIs) were extracted by isoelectric solubilization/precipitation (ISP) from the defatted gonads, and their functional properties were compared. Sodium dodecyl sulfate polyacrylamide gel electrophoresis results showed the similar protein pattern between each protein isolate and defatted gonad, indicating the high efficiency of ISP processing for protein recovery. Amino acid profileconfirmed that the mnGPIs and siGPIs could be potential sources of essential amino acid in nature. As regard to functional properties, mnGPIs showed higher water- and oil- holding capacities followed bysiGPIs and gcGPIs and all protein isolates presented great foaming property. As for emulsifying activity index (EAI), mnGPIs, gcGPIs, and siGPIs showed the minimum solubility and EAI at pH 5, 3, and 4, respectively, and behaved a pH-dependent manner. The gcGPIs revealed the highest EAI from pH 6 to 8 among the samples. In addition, circular dichroism showed increased content of β-sheet at the expense of α-helix and β-turn, suggesting the structure denaturation of the protein isolates. Indeed, no statistical difference was observed between secondary structure of mnGPIs and siGPIs. Moreover, ISP processing increased free sulfhydryl content of sea urchin protein isolates, but no difference was observed among the samples. Furthermore, siGPIs revealed the highest amount of total sulfhydryl and disulfide bonds, whereas both defatted gonads and protein isolates from G. crenularis presented the maximum surface hydrophobicity. These results suggest that gonad protein isolates from three species of sea urchin possess various functionalities and therefore can be potentially applied in food system. PRACTICAL APPLICATION: Sea urchin M. nudus, G. crenularis, and S. intermedius gonads are edible, whereas the functional properties of protein isolates from sea urchin gonad remain unknown. In this case, the extraction and comparison of three species of sea urchin gonad protein isolates will not only confirm functional properties but also screen food ingredients with suitable functions. In this study, functionalities of protein isolates derived from M. nudus, G. crenularis, and S. intermedius gonads would provide potential application in bakery food and meat products or as emulsifier candidates in food system.
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- 2020
8. Helicobacter pylori infection and the progression of atherosclerosis: A systematic review and meta‑analysis
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Hongshuo Shi, Guomin Si, Min Peng, Yujie Li, Chengda Dong, Yinghao Li, and Yunsheng Xu
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Helicobacter pylori infection ,medicine.medical_specialty ,Population ,Subgroup analysis ,Disease ,Pulse Wave Analysis ,Carotid Intima-Media Thickness ,Helicobacter Infections ,Risk Factors ,Internal medicine ,medicine ,Humans ,education ,Pulse wave velocity ,education.field_of_study ,Helicobacter pylori ,biology ,business.industry ,Gastroenterology ,General Medicine ,Middle Aged ,Atherosclerosis ,biology.organism_classification ,Cross-Sectional Studies ,Infectious Diseases ,Meta-analysis ,business ,Cohort study - Abstract
OBJECTIVE In recent years, many studies have tried to prove whether Helicobacter pylori (H. pylori) can promote the progression of atherosclerosis (AS), but the reported results are conflicting. Carotid intima-media thickness (CIMT), flow-mediated dilation (FMD), or pulse wave velocity (PWV) are the most commonly used indicators to evaluate the progress of AS. So, we collected and evaluated these three indicators to provide evidence-based medicine for the clinic. MATERIALS AND METHODS We included and evaluated studies on H. pylori infection and CIMT, FMD, or PWV from PubMed, Cochrane trials, and Embase databases before September 1, 2021, and language restrictions: English. Research types include cross-sectional studies, cohort studies, and case-control studies. The MINORS scale was used to evaluate the quality of these studies. For all studies, we choose a random-effects model and calculate the weighted mean difference (WMD) for analysis, and all our analyses use STATA software. RESULTS Meta-analysis shows that H. pylori infection can significantly increase CIMT (WMD = 0.059, 95% CI: 0.039, 0.079, p
- Published
- 2021
9. HPV16 E7‐induced upregulation of KDM2A promotes cervical cancer progression by regulating miR‐132–radixin pathway
- Author
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Linyu Zhu, Yiyi Lu, Jianrong Li, Yi Ren, Rongying Ou, Fengxing Tao, Wenfeng Li, Liang Zhao, Yunsheng Xu, and Qin He
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Transcriptional Activation ,0301 basic medicine ,Jumonji Domain-Containing Histone Demethylases ,Physiology ,Clinical Biochemistry ,Uterine Cervical Neoplasms ,KDM2A ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,Radixin ,Cell Line, Tumor ,Histone methylation ,microRNA ,Humans ,Medicine ,Epigenetics ,Promoter Regions, Genetic ,Cell Proliferation ,Cervical cancer ,biology ,business.industry ,F-Box Proteins ,Papillomavirus Infections ,Membrane Proteins ,Cell Biology ,medicine.disease ,Up-Regulation ,Gene Expression Regulation, Neoplastic ,Cytoskeletal Proteins ,MicroRNAs ,030104 developmental biology ,Tumor progression ,030220 oncology & carcinogenesis ,Disease Progression ,biology.protein ,Cancer research ,Female ,business - Abstract
Background Human papillomavirus (HPV) infection and viral proteins expression cause a number of epigenetic alterations leading to cervical carcinogenesis. The recent discovery of a large amount of histone methylation modifiers reveals important roles of these enzymes in regulating tumor progression. Methods The changes in expression of 48 histone methylation modifiers were assessed following knockdown of HPV16 E7 in CaSki cells. Lysine-specific demethylase 2A (KDM2A)-regulated microRNAs (miRNAs) in cervical cancer pathogenesis were disclosed using quantitative real-time polymerase chain reaction. The function of KDM2A-miRNAs on cervical cancer was investigated in vitro and in vivo. Results Upregulation of KDM2A induced by HPV16 E7 promotes cervical cancer cell proliferation and invasion and is correlated with poor prognosis in patients with cervical cancer. KDM2A physically interacts with the promoter of miR-132 and suppresses its expression by removing the mono or dimethyl group from H3K36 at the miR-132 locus. Functionally, miR-132 represses cancer cell proliferation and invasion by inhibiting radixin (RDX). Upregulated KDM2A promotes cervical cancer progression by repressing miR-132, which results in a derepression of RDX. Therefore, KDM2A functions as a tumor activator in cervical cancer pathogenesis by binding miR-132 promoter and abrogating its tumor suppressive function. Conclusion Our results suggest a function for KDM2A in cervical cancer progression and suggest its candidacy as a new prognostic biomarker and target for clinical management of cervical cancer.
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- 2018
10. Nanotheranostics: Dual-Stimuli Responsive Nanotheranostics for Multimodal Imaging Guided Trimodal Synergistic Therapy (Small 6/2017)
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Fan Wenpei, Chunlei Zhang, Sisi Huang, Yunsheng Xu, Jingjing Liu, Daxiang Cui, Zhiming Li, Wenxiu Hou, Jing Lin, Peng Huang, Yongxiang Luo, Chunxiao Li, and Shan Fang
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Multimodal imaging ,Stimuli responsive ,business.industry ,0206 medical engineering ,Nanotechnology ,02 engineering and technology ,General Chemistry ,DUAL (cognitive architecture) ,021001 nanoscience & nanotechnology ,020601 biomedical engineering ,Biomaterials ,Medicine ,General Materials Science ,0210 nano-technology ,business ,Neuroscience ,Biotechnology - Published
- 2017
11. Mutations of connexin 26 (GJB2) gene in a Chinese keratitis-ichthyosis-deafness syndrome patient with squamous cell carcinoma
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Yanli Wang, Shan Fang, Teng Ye, Haigang Zhu, Zhiming Li, Yunsheng Xu, Xueqi Zhang, Jingjing Liu, Qiuyun Ding, and Bingxu Li
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business.industry ,Keratitis–ichthyosis–deafness syndrome ,Point mutation ,Connexin ,Amino acid substitution ,Dermatology ,General Medicine ,medicine.disease ,Keratitis ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Gjb2 gene ,0302 clinical medicine ,030220 oncology & carcinogenesis ,medicine ,Carcinoma ,Cancer research ,Basal cell ,business - Published
- 2015
12. The concurrence of subacute cutaneous lupus erythematosus and hand-foot syndrome in a patient undergoing capecitabine chemotherapy
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Yunsheng Xu, Nanyan Jiang, and Zhiming Li
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medicine.medical_specialty ,Chemotherapy ,Unusual case ,business.industry ,medicine.medical_treatment ,Overlap syndrome ,Dermatology ,medicine.disease ,Hand-Foot Syndrome ,Surgery ,Subacute cutaneous lupus erythematosus ,Capecitabine ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,immune system diseases ,030220 oncology & carcinogenesis ,medicine ,skin and connective tissue diseases ,business ,Anti-SSA/Ro autoantibodies ,medicine.drug - Abstract
We describe an unusual case of subacute cutaneous lupus erythematosus concurrent with hand-foot syndrome, apparently associated with capecitabine treatment. We hypothesise that subacute cutaneous lupus erythematosus and hand-foot syndrome may occur in a novel overlap syndrome.
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- 2014
13. Dual-Stimuli Responsive Nanotheranostics for Multimodal Imaging Guided Trimodal Synergistic Therapy
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Fan Wenpei, Chunxiao Li, Sisi Huang, Wenxiu Hou, Daxiang Cui, Zhiming Li, Jing Lin, Yongxiang Luo, Peng Huang, Chunlei Zhang, Jingjing Liu, Yunsheng Xu, and Shan Fang
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Indocyanine Green ,Materials science ,medicine.medical_treatment ,Photodynamic therapy ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,Multimodal Imaging ,01 natural sciences ,Theranostic Nanomedicine ,Biomaterials ,Mice ,chemistry.chemical_compound ,In vivo ,Cell Line, Tumor ,medicine ,Animals ,Humans ,General Materials Science ,Photons ,Nanotubes ,Modality (human–computer interaction) ,Cell Death ,General Chemistry ,Hydrogen-Ion Concentration ,Photothermal therapy ,Silicon Dioxide ,021001 nanoscience & nanotechnology ,Combined Modality Therapy ,0104 chemical sciences ,Drug Liberation ,Nanomedicine ,Microscopy, Fluorescence ,chemistry ,Heat generation ,Drug delivery ,Fluorouracil ,Gold ,0210 nano-technology ,Indocyanine green ,Biotechnology - Abstract
Multimodal imaging guided synergistic therapy promises more accurate diagnosis than any single imaging modality, and higher therapeutic efficiency than any single one or their simple "mechanical" combination. Herein, we report a dual-stimuli responsive nanotheranostic based on a hierarchical nanoplatform, composed of mesoporous silica-coated gold nanorods (GNR@SiO2), Indocyanine Green (ICG), and 5-fluorouracil (5-FU), for in vivo multimodal imaging guided synergistic therapy. The 5-FU loaded ICG-conjugated silica-coated gold nanorods (GNR@SiO2-5-FU-ICG) was able to response specifically to the two stimuli of pH change and near-infrared (NIR) light irradiation. Both the NIR light irradiation and acidic environment accelerated the 5-FU release. Meanwhile, the heat generation and singlet oxygen production can be induced by GNR@SiO2-5-FU-ICG upon light irradiation. Most intriguingly, the nanoplatform also promises multimodal imaging such as two-photon luminescence, fluorescence, photoacoustic, photothermal imaging, as well as trimodal synergistic therapy such as photothermal therapy (PTT), photodynamic therapy (PDT), and chemotherapy. The cancer theranostic capability of GNR@SiO2-5-FU-ICG was evaluated both in vitro and in vivo. The trimodal synergistic therapy with the guidance of multimodal imaging exhibited remarkably enhanced treatment efficacy. This concept of a hierarchical nanoplatform integrates multiple diagnostic/therapeutic modalities into one platform, which can potentially be applied as personalized nanomedicine with drug delivery, diagnosis, and treatment.
- Published
- 2016
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