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Knockdown of circular RNA VANGL1 inhibits TGF‐β‐induced epithelial‐mesenchymal transition in melanoma cells by sponging miR‐150‐5p
- Source :
- Journal of Cellular and Molecular Medicine
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Melanoma is one of the most aggressive and life‐threatening skin cancers, and in this research, we aimed to explore the functional role of circular RNA VANGL1 (circVANGL1) in melanoma progression. The expression levels of circVANGL1 were observed to be significantly increased in clinical melanoma tissues and cell lines. Moreover, circVANGL1 knockdown suppressed, while circVANGL1 overexpression promoted the proliferation, migration and invasion abilities of melanoma cells. Further investigations confirmed the direct binding relation between circVANGL1 and miR‐150‐5p in melanoma, and restoration of miR‐150‐5p blocked the effects of circVANGL1 overexpression in melanoma cells. We further found that circVANGL1 was up‐regulated by TGF‐β treatment, and the enhanced EMT of TGF‐β‐treated melanoma cells was blocked by circVANGL1 knockdown. In conclusion, these results indicated that circVANGL1 might serve as a promising therapeutic target for melanoma.
- Subjects :
- Epithelial-Mesenchymal Transition
Skin Neoplasms
Apoptosis
Cell Movement
Transforming Growth Factor beta
Circular RNA
Cell Line, Tumor
miR-150
miR‐150‐5p
melanoma
medicine
Humans
circular RNA VANGL1
Epithelial–mesenchymal transition
neoplasms
Cell Proliferation
TGF‐β
Gene knockdown
Chemistry
Melanoma
EMT
Membrane Proteins
RNA, Circular
Original Articles
Cell Biology
medicine.disease
Up-Regulation
Gene Expression Regulation, Neoplastic
MicroRNAs
Cell culture
Direct binding
Cancer research
Molecular Medicine
RNA, Long Noncoding
Original Article
Carrier Proteins
Transforming growth factor
Subjects
Details
- ISSN :
- 15824934 and 15821838
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular and Molecular Medicine
- Accession number :
- edsair.doi.dedup.....b69cebc169baec29176da30be07432fb