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86 results on '"Travis, Ruth C"'

1. Genetic predisposition to metabolically unfavourable adiposity and prostate cancer risk: A Mendelian randomization analysis

Author: Perez‐Cornago, Aurora, primary, Smith‐Byrne, Karl, additional, Hazelwood, Emma, additional, Watling, Cody Z., additional, Martin, Susan, additional, Frayling, Timothy, additional, Lewis, Sarah, additional, Martin, Richard M., additional, Yaghootkar, Hanieh, additional, Travis, Ruth C., additional, and Key, Timothy J., additional
Published: 2023
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2. Protein and amino acid intakes in relation to prostate cancer risk and mortality—A prospective study in the European Prospective Investigation into Cancer and Nutrition

Author: Schmidt, Julie A., primary, Huybrechts, Inge, additional, Overvad, Kim, additional, Eriksen, Anne Kirstine, additional, Tjønneland, Anne, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Schulze, Matthias B., additional, Pala, Valeria, additional, Sacerdote, Carlotta, additional, Tumino, Rosario, additional, Bueno‐de‐Mesquita, Bas, additional, Sánchez, Maria‐Jose, additional, Huerta, José M., additional, Barricarte, Aurelio, additional, Amiano, Pilar, additional, Agudo, Antonio, additional, Bjartell, Anders, additional, Stocks, Tanja, additional, Thysell, Elin, additional, Wennberg, Maria, additional, Weiderpass, Elisabete, additional, Travis, Ruth C., additional, Key, Timothy J., additional, and Perez‐Cornago, Aurora, additional
Published: 2022
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3. Circulating tryptophan metabolites and risk of colon cancer: Results from case‐control and prospective cohort studies

Author: Papadimitriou, Nikos, primary, Gunter, Marc J., additional, Murphy, Neil, additional, Gicquiau, Audrey, additional, Achaintre, David, additional, Brezina, Stefanie, additional, Gumpenberger, Tanja, additional, Baierl, Andreas, additional, Ose, Jennifer, additional, Geijsen, Anne J. M. R., additional, van Roekel, Eline H., additional, Gsur, Andrea, additional, Gigic, Biljana, additional, Habermann, Nina, additional, Ulrich, Cornelia M., additional, Kampman, Ellen, additional, Weijenberg, Matty P., additional, Ueland, Per Magne, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Krogh, Vittorio, additional, Bueno‐de‐Mesquita, Bas, additional, Ardanaz, Eva, additional, Travis, Ruth C., additional, Schulze, Matthias B., additional, Sánchez, Maria‐José, additional, Colorado‐Yohar, Sandra M., additional, Weiderpass, Elisabete, additional, Scalbert, Augustin, additional, and Keski‐Rahkonen, Pekka, additional
Published: 2021
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4. Prospective analyses of testosterone and sex hormone‐binding globulin with the risk of 19 types of cancer in men and postmenopausal women in UK Biobank

Author: Watts, Eleanor L., primary, Perez‐Cornago, Aurora, additional, Knuppel, Anika, additional, Tsilidis, Konstantinos K., additional, Key, Timothy J., additional, and Travis, Ruth C., additional
Published: 2021
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5. Circulating insulin‐like growth factor‐I, total and free testosterone concentrations and prostate cancer risk in 200 000 men in UK Biobank

Author: Watts, Eleanor L., primary, Fensom, Georgina K., additional, Smith Byrne, Karl, additional, Perez‐Cornago, Aurora, additional, Allen, Naomi E., additional, Knuppel, Anika, additional, Gunter, Marc J., additional, Holmes, Michael V., additional, Martin, Richard M., additional, Murphy, Neil, additional, Tsilidis, Konstantinos K., additional, Yeap, Bu B., additional, Key, Timothy J., additional, and Travis, Ruth C., additional
Published: 2020
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6. Blood Metal Levels and Amyotrophic Lateral Sclerosis Risk: A Prospective Cohort

Author: Peters, Susan, primary, Broberg, Karin, additional, Gallo, Valentina, additional, Levi, Michael, additional, Kippler, Maria, additional, Vineis, Paolo, additional, Veldink, Jan, additional, van den Berg, Leonard, additional, Middleton, Lefkos, additional, Travis, Ruth C., additional, Bergmann, Manuela M., additional, Palli, Domenico, additional, Grioni, Sara, additional, Tumino, Rosario, additional, Elbaz, Alexis, additional, Vlaar, Tim, additional, Mancini, Francesca, additional, Kühn, Tilman, additional, Katzke, Verena, additional, Agudo, Antonio, additional, Goñi, Fernando, additional, Gómez, Jesús‐Humberto, additional, Rodríguez‐Barranco, Miguel, additional, Merino, Susana, additional, Barricarte, Aurelio, additional, Trichopoulou, Antonia, additional, Jenab, Mazda, additional, Weiderpass, Elisabete, additional, and Vermeulen, Roel, additional
Published: 2020
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7. Metabolic syndrome biomarkers and prostate cancer risk in the UK Biobank

Author: Monroy‐Iglesias, Maria J., primary, Russell, Beth, additional, Crawley, Danielle, additional, Allen, Naomi E., additional, Travis, Ruth C., additional, Perez‐Cornago, Aurora, additional, Van Hemelrijck, Mieke, additional, and Beckmann, Kerri, additional
Published: 2020
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8. Theoretical potential for endometrial cancer prevention through primary risk factor modification: Estimates from the EPIC cohort

Author: Fortner, Renée T., primary, Hüsing, Anika, additional, Dossus, Laure, additional, Tjønneland, Anne, additional, Overvad, Kim, additional, Dahm, Christina C., additional, Arveux, Patrick, additional, Fournier, Agnès, additional, Kvaskoff, Marina, additional, Schulze, Matthias B., additional, Bergmann, Manuela, additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, La Vecchia, Carlo, additional, Masala, Giovanna, additional, Pala, Valeria, additional, Mattiello, Amalia, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, van Gils, Carla H., additional, Monninkhof, Evelyn M., additional, Bonet, Catalina, additional, Quirós, José Ramón, additional, Sanchez, Maria‐Jose, additional, Rodríguez‐Palacios, Daniel‐Ángel, additional, Gurrea, Aurelio B, additional, Amiano, Pilar, additional, Allen, Naomi E., additional, Travis, Ruth C., additional, Gunter, Marc J., additional, Viallon, Vivian, additional, Weiderpass, Elisabete, additional, Riboli, Elio, additional, and Kaaks, Rudolf, additional
Published: 2020
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9. Hormone‐related diseases and prostate cancer: An English national record linkage study

Author: Watts, Eleanor L., primary, Goldacre, Raphael, additional, Key, Timothy J., additional, Allen, Naomi E., additional, Travis, Ruth C., additional, and Perez‐Cornago, Aurora, additional
Published: 2019
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10. Exogenous hormone use and cutaneous melanoma risk in women: The European Prospective Investigation into Cancer and Nutrition

Author: Cervenka, Iris, primary, Al Rahmoun, Marie, additional, Mahamat‐Saleh, Yahya, additional, Fournier, Agnès, additional, Boutron‐Ruault, Marie‐Christine, additional, Severi, Gianluca, additional, Caini, Saverio, additional, Palli, Domenico, additional, Ghiasvand, Reza, additional, Veierod, Marit B., additional, Botteri, Edoardo, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Fortner, Renée T., additional, Kaaks, Rudolf, additional, Schulze, Matthias B., additional, Panico, Salvatore, additional, Trichopoulou, Antonia, additional, Dessinioti, Clio, additional, Niforou, Katerina, additional, Sieri, Sabina, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Bueno‐de‐Mesquita, Bas, additional, Sandanger, Torkjel M., additional, Colorado‐Yohar, Sandra, additional, Sánchez, Maria J., additional, Gil Majuelo, Leire, additional, Lujan‐Barroso, Leila, additional, Ardanaz, Eva, additional, Merino, Susana, additional, Isaksson, Karolin, additional, Butt, Salma, additional, Ljuslinder, Ingrid, additional, Jansson, Malin, additional, Travis, Ruth C., additional, Khaw, Kay‐Tee, additional, Weiderpass, Elisabete, additional, Dossus, Laure, additional, Rinaldi, Sabina, additional, and Kvaskoff, Marina, additional
Published: 2019
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11. Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study

Author: Dossus, Laure, Franceschi, Silvia, Biessy, Carine, Navionis, Anne-Sophie, Travis, Ruth C, Weiderpass, Elisabete, Scalbert, Augustin, Romieu, Isabelle, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Bonnet, Fabrice, Fournier, Agnès, Fortner, Renee T, Kaaks, Rudolf, Aleksandrova, Krasimira, Trichopoulou, Antonia, La Vecchia, Carlo, Peppa, Eleni, Tumino, Rosario, Panico, Salvatore, Palli, Domenico, Agnoli, Claudia, Vineis, Paolo, Bueno-de-Mesquita, Bas, Peeters, Petra H, Skeie, Guri, Zamora-Ros, Raul, Chirlaque, María-Dolores, Ardanaz, Eva, Sánchez, Maria-Jose, Quirós, Jose Ramón, Dorronsoro, Miren, Sandström, Maria, Nilsson, Lena Maria, Schmidt, Julie A, Khaw, Kay-Tee, Tsilidis, Konstantinos K, Aune, Dagfinn, Riboli, Elio, Rinaldi, Sabina, Institut National du Cancer, Dossus, Laure, Franceschi, Silvia, Biessy, Carine, Navionis, Anne-Sophie, Travis, Ruth C., Weiderpass, Elisabete, Scalbert, Augustin, Romieu, Isabelle, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Bonnet, Fabrice, Fournier, Agnè, Fortner, Renee T., Kaaks, Rudolf, Aleksandrova, Krasimira, Trichopoulou, Antonia, La Vecchia, Carlo, Peppa, Eleni, Tumino, Rosario, Panico, Salvatore, Palli, Domenico, Agnoli, Claudia, Vineis, Paolo, Bueno-de-Mesquita, H. Ba, Peeters, Petra H., Skeie, Guri, Zamora-Ros, Raul, Chirlaque, María-Dolore, Ardanaz, Eva, Sánchez, Maria-Jose, Ramón Quirós, Jose, Dorronsoro, Miren, Sandström, Maria, Nilsson, Lena Maria, Schmidt, Julie A., Khaw, Kay-Tee, Tsilidis, Konstantinos K., Aune, Dagfinn, Riboli, Elio, and Rinaldi, Sabina
Subjects: Adult, Male, Cancer Research, GENE POLYMORPHISM, BIOMARKERS, prospective cohort, Body Mass Index, POOLED ANALYSIS, Adipokines, Risk Factors, Journal Article, Biomarkers, Tumor, Càncer de tiroide, thyroid cancer, cytokine, Humans, BREAST-CANCER, Prospective Studies, Thyroid Neoplasms, Oncology & Carcinogenesis, Obesity, Aged, ENDOMETRIAL CANCER-RISK, Science & Technology, adipokine, Interleukin-6, VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762, Incidence, Public Health, Global Health, Social Medicine and Epidemiology, Middle Aged, INTERLEUKIN-10, C-REACTIVE PROTEIN, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, ADIPOSE-TISSUE, Oncology, inflammation, Case-Control Studies, Thyroid gland cancer, PLASMA ADIPONECTIN CONCENTRATIONS, Obesitat, Female, CIRCULATING ADIPONECTIN, Adiponectin, Life Sciences & Biomedicine, 1112 Oncology And Carcinogenesis
Abstract: Source at https://doi.org/10.1002/ijc.31172. Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C‐reactive protein, interleukin (IL)‐6, IL‐10 and tumor necrosis factor (TNF)‐α and the risk of TC. A case‐control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer‐free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (ORT3vs.T1 = 0.69, 95% CI: 0.49–0.98, Ptrend = 0.04) but not among men (ORT3vs.T1 = 1.36, 95% CI: 0.67–2.76, Ptrend = 0.37). Increasing levels of IL‐10 were positively associated with TC risk in both genders and significantly so in women (ORT3vs.T1 = 1.59, 95% CI: 1.13–2.25, Ptrend = 0.01) but not in men (ORT3vs.T1 = 1.78, 95% CI: 0.80–3.98, Ptrend = 0.17). Leptin, CRP, IL‐6 and TNF‐α were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL‐10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight.
Published: 2017

12. Intake of Individual Fatty Acids and Risk of Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition

Author: Perez‐Cornago, Aurora, Huybrechts, Inge, Appleby, Paul N., Schmidt, Julie A., Crowe, Francesca L., Overvad, Kim, Tjønneland, Anne, Kühn, Tilman, Katzke, Verena, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Grioni, Sara, Palli, Domenico, Sacerdote, Carlotta, Tumino, Rosario, Bueno‐de‐Mesquita, H. Bas, Larrañaga, Nerea, Sánchez, Maria‐Jose, Quirós, J. Ramón, Ardanaz, Eva, Chirlaque, María‐Dolores, Agudo, Antonio, Bjartell, Anders, Wallström, Peter, Chajes, Veronique, Tsilidis, Konstantinos K., Aune, Dagfinn, Riboli, Elio, Travis, Ruth C., and Key, Timothy J.
Subjects: Adult, Male, Prostatic Neoplasms/epidemiology, Àcids grassos, DIETARY-FAT, CALCIUM, ENERGY, SDG 3 - Good Health and Well-being, Risk Factors, Humans, COHORT, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, Prospective Studies, VALIDITY, Fatty acids, Nutrició, Aged, Dietary Fats/administration & dosage, Nutrition, Science & Technology, Prostate cancer, Càncer de pròstata, Fatty Acids, Prostatic Neoplasms, Fatty Acids/administration & dosage, ASSOCIATION, tumor subtypes, Middle Aged, prospective, prostate cancer, Dietary Fats, PHYSICAL-ACTIVITY, individual fatty acids, Oncology, Life Sciences & Biomedicine, Cancer Epidemiology
Abstract: The associations of individual dietary fatty acids with prostate cancer risk have not been examined comprehensively. We examined the prospective association of individual dietary fatty acids with prostate cancer risk overall, by tumor subtypes, and prostate cancer death. 142,239 men from the European Prospective Investigation into Cancer and Nutrition who were free from cancer at recruitment were included. Dietary intakes of individual fatty acids were estimated using center‐specific validated dietary questionnaires at baseline and calibrated with 24‐h recalls. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). After an average follow‐up of 13.9 years, 7,036 prostate cancer cases and 936 prostate cancer deaths were ascertained. Intakes of individual fatty acids were not related to overall prostate cancer risk. There was evidence of heterogeneity in the association of some short chain saturated fatty acids with prostate cancer risk by tumor stage (p heterogeneity, What's new? Are individual dietary fatty acids associated with prostate cancer development and progression? In this large, prospective study, the authors found that for prostate cancer overall, the answer is no. However, a higher intake of butyric acid may be associated with an increased risk of advanced‐stage prostate cancer, and higher intakes of eicosenoic and eicosapentaenoic acids may be positively associated with risk of lethal prostate cancer.
Published: 2019

13. Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition

Author: Sen, Abhijit, Papadimitriou, Nikos, Lagiou, Pagona, Perez-Cornago, Aurora, Travis, Ruth C, Key, Timothy J, Murphy, Neil, Gunter, Marc, Freisling, Heinz, Tzoulaki, Ioanna, Muller, David C, Cross, Amanda J, Lopez, David S, Bergmann, Manuela, Boeing, Heiner, Bamia, Christina, Kotanidou, Anastasia, Karakatsani, Anna, Tjønneland, Anne, Kyrø, Cecilie, Outzen, Malene, Redondo, María-Luisa, Cayssials, Valerie, Chirlaque, Maria-Dolores, Barricarte, Aurelio, Sánchez, Maria-Jose, Larrañaga, Nerea, Tumino, Rosario, Grioni, Sara, Palli, Domenico, Caini, Saverio, Sacerdote, Carlotta, Bueno-De-Mesquita, Bas, Kühn, Tilman, Kaaks, Rudolf, Nilsson, Lena Maria, Landberg, Rikard, Wallström, Peter, Drake, Isabel, Bech, Bodil Hammer, Overvad, Kim, Aune, Dagfinn, Khaw, Kay-Tee, Riboli, Elio, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Tsilidis, Konstantinos K, Imperial College Trust, Perez-Cornago, Aurora [0000-0002-5652-356X], Murphy, Neil [0000-0003-3347-8249], Kyrø, Cecilie [0000-0002-9083-8960], Palli, Domenico [0000-0002-5558-2437], Sacerdote, Carlotta [0000-0002-8008-5096], Kühn, Tilman [0000-0001-7702-317X], Kaaks, Rudolf [0000-0003-3751-3929], Drake, Isabel [0000-0002-6500-6310], Tsilidis, Konstantinos K [0000-0002-8452-8472], and Apollo - University of Cambridge Repository
Subjects: Adult, Male, tea, COMPONENTS KAHWEOL, coffee, PROGRESSION, Diet Surveys, DIET, Cohort Studies, Risk Factors, Humans, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, METAANALYSIS, CAFESTOL, Aged, Proportional Hazards Models, caffeinated, Science & Technology, Incidence, Prostatic Neoplasms, Middle Aged, prostate cancer, Europe, PHYSICAL-ACTIVITY, Oncology, decaffeinated, EPIC, FOLLOW-UP, Life Sciences & Biomedicine
Abstract: The epidemiological evidence regarding the association of coffee and tea consumption with prostate cancer risk is inconclusive, and few cohort studies have assessed these associations by disease stage and grade. We examined the associations of coffee (total, caffeinated and decaffeinated) and tea intake with prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition. Among 142,196 men, 7,036 incident prostate cancer cases were diagnosed over 14 years of follow-up. Data on coffee and tea consumption were collected through validated country-specific food questionnaires at baseline. We used Cox proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (CI). Models were stratified by center and age, and adjusted for anthropometric, lifestyle and dietary factors. Median coffee and tea intake were 375 mL/day and 106 mL/day, respectively, but large variations existed by country. Comparing the highest (median of 855 mL/day) versus lowest (median of 103 mL/day) consumers of coffee and tea (450 mL/day versus 12 mL/day) the HRs were 1.02 (95% CI, 0.94-1.09) and 0.98 (95% CI, 0.90-1.07) for risk of total prostate cancer, and 0.97 (95% CI, 0.79-1.21) and 0.89 (95% CI, 0.70-1.13) for risk of fatal disease, respectively. No evidence of association was seen for consumption of total, caffeinated or decaffeinated coffee or tea and risk of total prostate cancer or cancer by stage, grade or fatality in this large cohort. Further investigations are needed to clarify whether an association exists by different preparations or by concentrations and constituents of these beverages. This article is protected by copyright. All rights reserved.
Published: 2018

14. Genetic overlap between autoimmune diseases and non‐Hodgkin lymphoma subtypes

Author: Din, Lennox, primary, Sheikh, Mohammad, additional, Kosaraju, Nikitha, additional, Smedby, Karin Ekstrom, additional, Bernatsky, Sasha, additional, Berndt, Sonja I., additional, Skibola, Christine F., additional, Nieters, Alexandra, additional, Wang, Sophia, additional, McKay, James D., additional, Cocco, Pierluigi, additional, Maynadié, Marc, additional, Foretová, Lenka, additional, Staines, Anthony, additional, Mack, Thomas M., additional, de Sanjosé, Silvia, additional, Vyse, Timothy J., additional, Padyukov, Leonid, additional, Monnereau, Alain, additional, Arslan, Alan A., additional, Moore, Amy, additional, Brooks‐Wilson, Angela R., additional, Novak, Anne J., additional, Glimelius, Bengt, additional, Birmann, Brenda M., additional, Link, Brian K., additional, Stewart, Carolyn, additional, Vajdic, Claire M., additional, Haioun, Corinne, additional, Magnani, Corrado, additional, Conti, David V., additional, Cox, David G., additional, Casabonne, Delphine, additional, Albanes, Demetrius, additional, Kane, Eleanor, additional, Roman, Eve, additional, Muzi, Giacomo, additional, Salles, Gilles, additional, Giles, Graham G., additional, Adami, Hans‐Olov, additional, Ghesquières, Hervé, additional, De Vivo, Immaculata, additional, Clavel, Jacqueline, additional, Cerhan, James R., additional, Spinelli, John J., additional, Hofmann, Jonathan, additional, Vijai, Joseph, additional, Curtin, Karen, additional, Costenbader, Karen H., additional, Onel, Kenan, additional, Offit, Kenneth, additional, Teras, Lauren R., additional, Morton, Lindsay, additional, Conde, Lucia, additional, Miligi, Lucia, additional, Melbye, Mads, additional, Ennas, Maria Grazia, additional, Liebow, Mark, additional, Purdue, Mark P., additional, Glenn, Martha, additional, Southey, Melissa C., additional, Din, Morris, additional, Rothman, Nathaniel, additional, Camp, Nicola J., additional, Wong Doo, Nicole, additional, Becker, Nikolaus, additional, Pradhan, Nisha, additional, Bracci, Paige M., additional, Boffetta, Paolo, additional, Vineis, Paolo, additional, Brennan, Paul, additional, Kraft, Peter, additional, Lan, Qing, additional, Severson, Richard K., additional, Vermeulen, Roel C. H., additional, Milne, Roger L., additional, Kaaks, Rudolph, additional, Travis, Ruth C., additional, Weinstein, Stephanie J., additional, Chanock, Stephen J., additional, Ansell, Stephen M., additional, Slager, Susan L., additional, Zheng, Tongzhang, additional, Zhang, Yawei, additional, Benavente, Yolanda, additional, Taub, Zachary, additional, Madireddy, Lohith, additional, Gourraud, Pierre‐Antoine, additional, Oksenberg, Jorge R., additional, Cozen, Wendy, additional, Hjalgrim, Henrik, additional, and Khankhanian, Pouya, additional
Published: 2019
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15. Patterns in metabolite profile are associated with risk of more aggressive prostate cancer: A prospective study of 3,057 matched case–control sets from EPIC

Author: Schmidt, Julie A., primary, Fensom, Georgina K., additional, Rinaldi, Sabina, additional, Scalbert, Augustin, additional, Appleby, Paul N., additional, Achaintre, David, additional, Gicquiau, Audrey, additional, Gunter, Marc J., additional, Ferrari, Pietro, additional, Kaaks, Rudolf, additional, Kühn, Tilman, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, Peppa, Eleni, additional, Palli, Domenico, additional, Sieri, Sabina, additional, Tumino, Rosario, additional, Bueno‐de‐Mesquita, Bas, additional, Agudo, Antonio, additional, Sánchez, Maria‐Jose, additional, Chirlaque, María‐Dolores, additional, Ardanaz, Eva, additional, Larrañaga, Nerea, additional, Perez‐Cornago, Aurora, additional, Assi, Nada, additional, Riboli, Elio, additional, Tsilidis, Konstantinos K., additional, Key, Timothy J., additional, and Travis, Ruth C., additional
Published: 2019
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16. The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF‐I, IGF‐II, IGFBP‐1, IGFBP‐2 and IGFBP‐3 in a pooled analysis of 16,024 men from 22 studies

Author: Watts, Eleanor L., primary, Perez‐Cornago, Aurora, additional, Appleby, Paul N., additional, Albanes, Demetrius, additional, Ardanaz, Eva, additional, Black, Amanda, additional, Bueno‐de‐Mesquita, H. Bas, additional, Chan, June M., additional, Chen, Chu, additional, Chubb, S.A. Paul, additional, Cook, Michael B., additional, Deschasaux, Mélanie, additional, Donovan, Jenny L., additional, English, Dallas R., additional, Flicker, Leon, additional, Freedman, Neal D., additional, Galan, Pilar, additional, Giles, Graham G., additional, Giovannucci, Edward L., additional, Gunter, Marc J., additional, Habel, Laurel A., additional, Häggström, Christel, additional, Haiman, Christopher, additional, Hamdy, Freddie C., additional, Hercberg, Serge, additional, Holly, Jeff M., additional, Huang, Jiaqi, additional, Huang, Wen‐Yi, additional, Johansson, Mattias, additional, Kaaks, Rudolf, additional, Kubo, Tatsuhiko, additional, Lane, J. Athene, additional, Layne, Tracy M., additional, Le Marchand, Loic, additional, Martin, Richard M., additional, Metter, E. Jeffrey, additional, Mikami, Kazuya, additional, Milne, Roger L., additional, Morris, Howard A., additional, Mucci, Lorelei A., additional, Neal, David E., additional, Neuhouser, Marian L., additional, Oliver, Steven E., additional, Overvad, Kim, additional, Ozasa, Kotaro, additional, Pala, Valeria, additional, Pernar, Claire H., additional, Pollak, Michael, additional, Rowlands, Mari‐Anne, additional, Schaefer, Catherine A., additional, Schenk, Jeannette M., additional, Stattin, Pär, additional, Tamakoshi, Akiko, additional, Thysell, Elin, additional, Touvier, Mathilde, additional, Trichopoulou, Antonia, additional, Tsilidis, Konstantinos K., additional, Van Den Eeden, Stephen K., additional, Weinstein, Stephanie J., additional, Wilkens, Lynne, additional, Yeap, Bu B., additional, Key, Timothy J., additional, Allen, Naomi E., additional, and Travis, Ruth C., additional
Published: 2019
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17. Intake of individual fatty acids and risk of prostate cancer in the European prospective investigation into cancer and nutrition

Author: Perez‐Cornago, Aurora, primary, Huybrechts, Inge, additional, Appleby, Paul N., additional, Schmidt, Julie A., additional, Crowe, Francesca L., additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Kühn, Tilman, additional, Katzke, Verena, additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, Peppa, Eleni, additional, Grioni, Sara, additional, Palli, Domenico, additional, Sacerdote, Carlotta, additional, Tumino, Rosario, additional, Bueno‐de‐Mesquita, H. Bas, additional, Larrañaga, Nerea, additional, Sánchez, Maria‐Jose, additional, Quirós, J. Ramón, additional, Ardanaz, Eva, additional, Chirlaque, María‐Dolores, additional, Agudo, Antonio, additional, Bjartell, Anders, additional, Wallström, Peter, additional, Chajes, Veronique, additional, Tsilidis, Konstantinos K., additional, Aune, Dagfinn, additional, Riboli, Elio, additional, Travis, Ruth C., additional, and Key, Timothy J., additional
Published: 2019
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18. Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium

Author: Fortner, Renée T., primary, Poole, Elizabeth M., additional, Wentzensen, Nicolas A., additional, Trabert, Britton, additional, White, Emily, additional, Arslan, Alan A., additional, Patel, Alpa V., additional, Setiawan, V. Wendy, additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, Adami, Hans‐Olov, additional, Black, Amanda, additional, Bernstein, Leslie, additional, Brinton, Louise A., additional, Buring, Julie, additional, Clendenen, Tess V., additional, Fournier, Agnès, additional, Fraser, Gary, additional, Gapstur, Susan M., additional, Gaudet, Mia M., additional, Giles, Graham G., additional, Gram, Inger T., additional, Hartge, Patricia, additional, Hoffman‐Bolton, Judith, additional, Idahl, Annika, additional, Kaaks, Rudolf, additional, Kirsh, Victoria A., additional, Knutsen, Synnove, additional, Koh, Woon‐Puay, additional, Lacey, James V., additional, Lee, I‐Min, additional, Lundin, Eva, additional, Merritt, Melissa A., additional, Milne, Roger L., additional, Onland‐Moret, N. Charlotte, additional, Peters, Ulrike, additional, Poynter, Jenny N., additional, Rinaldi, Sabina, additional, Robien, Kim, additional, Rohan, Thomas, additional, Sánchez, Maria‐José, additional, Schairer, Catherine, additional, Schouten, Leo J., additional, Tjonneland, Anne, additional, Townsend, Mary K., additional, Travis, Ruth C., additional, Trichopoulou, Antonia, additional, Brandt, Piet A., additional, Vineis, Paolo, additional, Wilkens, Lynne, additional, Wolk, Alicja, additional, Yang, Hannah P., additional, Zeleniuch‐Jacquotte, Anne, additional, and Tworoger, Shelley S., additional
Published: 2019
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19. Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study

Author: Brunner, Clair, Davies, Neil M., Martin, Richard M., Eeles, Rosalind, Easton, Doug, Kote‐Jarai, Zsofia, Al Olama, Ali Amin, Benlloch, Sara, Muir, Kenneth, Giles, Graham, Wiklund, Fredrik, Gronberg, Henrik, Haiman, Christopher A., Schleutker, Johanna, Nordestgaard, Børge G., Travis, Ruth C., Neal, David, Donovan, Jenny, Hamdy, Freddie C., Pashayan, Nora, Khaw, Kay‐Tee, Stanford, Janet L., Blot, William J., Thibodeau, Stephen, Maier, Christiane, Kibel, Adam S., Cybulski, Cezary, Cannon‐Albright, Lisa, Brenner, Hermann, Park, Jong, Kaneva, Radka, Batra, Jyotsna, Teixeira, Manuel R., Pandha, Hardev, and Zuccolo, Luisa
Subjects: Aged, 80 and over, Male, Alcohol Drinking, alcohol, Aldehyde Dehydrogenase, Mitochondrial, Incidence, Prostatic Neoplasms, Retinal Dehydrogenase, Aldehyde Dehydrogenase, Middle Aged, prostate cancer, Polymorphism, Single Nucleotide, Survival Analysis, Aldehyde Dehydrogenase 1 Family, Linkage Disequilibrium, Case-Control Studies, Disease Progression, Humans, Regression Analysis, alcohol metabolising genes, Neoplasm Grading, Mendelian randomisation, Cancer Epidemiology, Aged
Abstract: Prostate cancer is the most common cancer in men in developed countries, and is a target for risk reduction strategies. The effects of alcohol consumption on prostate cancer incidence and survival remain unclear, potentially due to methodological limitations of observational studies. In this study, we investigated the associations of genetic variants in alcohol‐metabolising genes with prostate cancer incidence and survival. We analysed data from 23,868 men with prostate cancer and 23,051 controls from 25 studies within the international PRACTICAL Consortium. Study‐specific associations of 68 single nucleotide polymorphisms (SNPs) in 8 alcohol‐metabolising genes (Alcohol Dehydrogenases (ADHs) and Aldehyde Dehydrogenases (ALDHs)) with prostate cancer diagnosis and prostate cancer‐specific mortality, by grade, were assessed using logistic and Cox regression models, respectively. The data across the 25 studies were meta‐analysed using fixed‐effect and random‐effects models. We found little evidence that variants in alcohol metabolising genes were associated with prostate cancer diagnosis. Four variants in two genes exceeded the multiple testing threshold for associations with prostate cancer mortality in fixed‐effect meta‐analyses. SNPs within ALDH1A2 associated with prostate cancer mortality were rs1441817 (fixed effects hazard ratio, HRfixed = 0.78; 95% confidence interval (95%CI):0.66,0.91; p values = 0.002); rs12910509, HRfixed = 0.76; 95%CI:0.64,0.91; p values = 0.003); and rs8041922 (HRfixed = 0.76; 95%CI:0.64,0.91; p values = 0.002). These SNPs were in linkage disequilibrium with each other. In ALDH1B1, rs10973794 (HRfixed = 1.43; 95%CI:1.14,1.79; p values = 0.002) was associated with prostate cancer mortality in men with low‐grade prostate cancer. These results suggest that alcohol consumption is unlikely to affect prostate cancer incidence, but it may influence disease progression., What's new? Alcohol may spur prostate cancer progression, though it does not appear to affect incidence, according to new analysis. Variation in genes involved in alcohol metabolism affect how much the body is exposed to carcinogenic metabolites. These authors examined 68 genetic variants in alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes, seeking a link with prostate cancer risk. While they found no evidence that these variants alter prostate cancer incidence, they did show that SNPs in the ALDH1A2 gene affect prostate cancer mortality. From a public health standpoint, these results suggest reducing alcohol consumption could slow prostate cancer disease progression.
Published: 2017

20. Circulating insulin‐like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition

Author: Bradbury, Kathryn E., primary, Appleby, Paul N., additional, Tipper, Sarah J., additional, Travis, Ruth C., additional, Allen, Naomi E., additional, Kvaskoff, Marina, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Halkjær, Jytte, additional, Cervenka, Iris, additional, Mahamat‐Saleh, Yahya, additional, Bonnet, Fabrice, additional, Kaaks, Rudolf, additional, Fortner, Renée T., additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, La Vecchia, Carlo, additional, Stratigos, Alexander J., additional, Palli, Domenico, additional, Grioni, Sara, additional, Matullo, Giuseppe, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Peeters, Petra H., additional, Bueno‐de‐Mesquita, H. Bas, additional, Ghiasvand, Reza, additional, Veierød, Marit B., additional, Weiderpass, Elisabete, additional, Bonet, Catalina, additional, Molina, Elena, additional, Huerta, José M., additional, Larrañaga, Nerea, additional, Barricarte, Aurelio, additional, Merino, Susana, additional, Isaksson, Karolin, additional, Stocks, Tanja, additional, Ljuslinder, Ingrid, additional, Hemmingsson, Oskar, additional, Wareham, Nick, additional, Khaw, Kay‐Tee, additional, Gunter, Marc J., additional, Rinaldi, Sabina, additional, Tsilidis, Konstantinos K., additional, Aune, Dagfinn, additional, Riboli, Elio, additional, and Key, Timothy J., additional
Published: 2018
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21. CA19‐9 and apolipoprotein‐A2 isoforms as detection markers for pancreatic cancer: a prospective evaluation

Author: Honda, Kazufumi, primary, Katzke, Verena A., additional, Hüsing, Anika, additional, Okaya, Shinobu, additional, Shoji, Hirokazu, additional, Onidani, Kaoru, additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Overvad, Kim, additional, Weiderpass, Elisabete, additional, Vineis, Paolo, additional, Muller, David, additional, Tsilidis, Kostas, additional, Palli, Domenico, additional, Pala, Valeria, additional, Tumino, Rosario, additional, Naccarati, Alessio, additional, Panico, Salvatore, additional, Aleksandrova, Krasimira, additional, Boeing, Heiner, additional, Bueno‐de‐Mesquita, H. Bas, additional, Peeters, Petra H., additional, Trichopoulou, Antonia, additional, Lagiou, Pagona, additional, Khaw, Kay‐Tee, additional, Wareham, Nick, additional, Travis, Ruth C., additional, Merino, Susana, additional, Duell, Eric J., additional, Rodríguez‐Barranco, Miguel, additional, Chirlaque, María Dolores, additional, Barricarte, Aurelio, additional, Rebours, Vinciane, additional, Boutron‐Ruault, Marie‐Chiristine, additional, Romana Mancini, Francesca, additional, Brennan, Paul, additional, Scelo, Ghislaine, additional, Manjer, Jonas, additional, Sund, Malin, additional, Öhlund, Daniel, additional, Canzian, Federico, additional, and Kaaks, Rudolf, additional
Published: 2018
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22. Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition

Author: Sen, Abhijit, primary, Papadimitriou, Nikos, additional, Lagiou, Pagona, additional, Perez-Cornago, Aurora, additional, Travis, Ruth C., additional, Key, Timothy J., additional, Murphy, Neil, additional, Gunter, Marc, additional, Freisling, Heinz, additional, Tzoulaki, Ioanna, additional, Muller, David C., additional, Cross, Amanda J., additional, Lopez, David S., additional, Bergmann, Manuela, additional, Boeing, Heiner, additional, Bamia, Christina, additional, Kotanidou, Anastasia, additional, Karakatsani, Anna, additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Outzen, Malene, additional, Redondo, María-Luisa, additional, Cayssials, Valerie, additional, Chirlaque, Maria-Dolores, additional, Barricarte, Aurelio, additional, Sánchez, Maria-Jose, additional, Larrañaga, Nerea, additional, Tumino, Rosario, additional, Grioni, Sara, additional, Palli, Domenico, additional, Caini, Saverio, additional, Sacerdote, Carlotta, additional, Bueno-de-Mesquita, Bas, additional, Kühn, Tilman, additional, Kaaks, Rudolf, additional, Nilsson, Lena Maria, additional, Landberg, Rikard, additional, Wallström, Peter, additional, Drake, Isabel, additional, Bech, Bodil Hammer, additional, Overvad, Kim, additional, Aune, Dagfinn, additional, Khaw, Kay-Tee, additional, Riboli, Elio, additional, Trichopoulos, Dimitrios, additional, Trichopoulou, Antonia, additional, and Tsilidis, Konstantinos K., additional
Published: 2018
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23. Fiber intake modulates the association of alcohol intake with breast cancer

Author: Romieu, Isabelle, Ferrari, Pietro, Chajès, Veronique, de Batlle, Jordi, Biessy, Carine, Scoccianti, Chiara, Dossus, Laure, Boutron, Marie Christine, Bastide, Nadia, Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Kaaks, Rudolf, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Vineis, Paolo, Bueno de Mesquita, H. B. As, Gils, Carla H, Peeters, Petra H, Lund, Eiliv, Skeie, Guri, Weiderpass, Elisabete, Quirós, J. Ramón, Chirlaque, María Dolores, Ardanaz, Eva, Sánchez, María José, Duell, Eric J, Amiano Etxezarreta, Pilar, Borgquist, Signe, Hallmans, Göran, Johansson, Ingegerd, Nilsson, Lena Maria, Khaw, Kay Tee, Wareham, Nick, Key, Timothy J, Travis, Ruth C, Murphy, Neil, Wark, Petra A, Riboli, Elio, PANICO, SALVATORE, University Medical Center Utrecht, Imperial College Trust, Romieu, Isabelle, Ferrari, Pietro, Chajès, Veronique, de Batlle, Jordi, Biessy, Carine, Scoccianti, Chiara, Dossus, Laure, Boutron, Marie Christine, Bastide, Nadia, Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Kaaks, Rudolf, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrio, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Bueno de Mesquita, H. B. A, Gils, Carla H, Peeters, Petra H, Lund, Eiliv, Skeie, Guri, Weiderpass, Elisabete, Quirós, J. Ramón, Chirlaque, María Dolore, Ardanaz, Eva, Sánchez, María José, Duell, Eric J, Amiano Etxezarreta, Pilar, Borgquist, Signe, Hallmans, Göran, Johansson, Ingegerd, Nilsson, Lena Maria, Khaw, Kay Tee, Wareham, Nick, Key, Timothy J, Travis, Ruth C, Murphy, Neil, Wark, Petra A, and Riboli, Elio
Subjects: Adult, Dietary Fiber, Cancer Research, Alcohol Drinking, Breast Neoplasms, Article, breast cancer, Risk Factors, Vegetables, Journal Article, Humans, Oncology & Carcinogenesis, Prospective Studies, Life Style, Aged, Proportional Hazards Models, Medicine(all), Ethanol, VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762, alcohol, Estrogens, Middle Aged, Diet, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762, nutrition, Oncology, Female, epidemiology, 1112 Oncology And Carcinogenesis
Abstract: Accepted manuscript version. Published version available at https://doi.org/10.1002/ijc.30415. Alcohol intake has been related to an increased risk of breast cancer (BC) while dietary fiber intake has been inversely associated to BC risk. A beneficial effect of fibers on ethanol carcinogenesis through their impact on estrogen levels is still controversial. We investigated the role of dietary fiber as a modifying factor of the association of alcohol and BC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 334,850 women aged 35–70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average. Information on fiber and alcohol intake at baseline and average lifetime alcohol intake were calculated from country‐specific dietary and lifestyle questionnaires. Hazard ratios (HR) of developing invasive BC according to different levels of alcohol and fiber intake were computed. During 3,670,439 person‐years, 11,576 incident BC cases were diagnosed. For subjects with low intake of fiber (24.2 g/day) the risk of BC was 1.02 (0.99–1.05) (test for interaction p = 0.011). This modulating effect was stronger for fiber from vegetables. Our results suggest that fiber intake may modulate the positive association of alcohol intake and BC. Alcohol is well known to increase the risk for BC, while a fiber‐rich diet has the opposite effect. Here the authors find a significant interaction between both lifestyle factors indicating that high fiber intake can ease the adverse effects associated with alcohol consumption. Consequently, women with high alcohol intake and low fiber intake (
Published: 2016

24. Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis

Author: Taylor, Amy E, Martin, Richard M, Geybels, Milan S, Stanford, Janet L, Shui, Irene, Eeles, Rosalind, Easton, Doug, Kote-Jarai, Zsofia, Amin Al Olama, Ali, Benlloch, Sara, Muir, Kenneth, Giles, Graham G, Wiklund, Fredrik, Gronberg, Henrik, Haiman, Christopher A, Schleutker, Johanna, Nordestgaard, Børge G, Travis, Ruth C, Neal, David, Pashayan, Nora, Khaw, Kay-Tee, Blot, William, Thibodeau, Stephen, Maier, Christiane, Kibel, Adam S, Cybulski, Cezary, Cannon-Albright, Lisa, Brenner, Hermann, Park, Jong, Kaneva, Radka, Batra, Jyotsna, Teixeira, Manuel R, Pandha, Hardev, PRACTICAL Consortium, Donovan, Jenny, Munafò, Marcus R, Easton, Douglas [0000-0003-2444-3247], Amin Al Olama, Ali [0000-0002-7178-3431], Khaw, Kay-Tee [0000-0002-8802-2903], and Apollo - University of Cambridge Repository
Subjects: Male, Prostate cancer, Tobacco and Alcohol, coffee, Genetic Variation, Prostatic Neoplasms, Mendelian Randomization Analysis, Middle Aged, Brain and Behaviour, prostate cancer, Centre for Surgical Research, Mendelian Randomization, Risk Factors, Mendelian randomization, Disease Progression, Humans, ICEP, Alleles, Aged
Abstract: Coffee consumption has been shown in some studies to be associated with lower risk of prostate cancer. However, it is unclear if this association is causal or due to confounding or reverse causality. We conducted a Mendelian randomisation analysis to investigate the causal effects of coffee consumption on prostate cancer risk and progression. We used two genetic variants robustly associated with caffeine intake (rs4410790 and rs2472297) as proxies for coffee consumption in a sample of 46,687 men of European ancestry from 25 studies in the PRACTICAL consortium. Associations between genetic variants and prostate cancer case status, stage and grade were assessed by logistic regression and with all-cause and prostate cancer-specific mortality using Cox proportional hazards regression. There was no clear evidence that a genetic risk score combining rs4410790 and rs2472297 was associated with prostate cancer risk (OR per additional coffee increasing allele: 1.01, 95% CI: 0.98,1.03) or having high-grade compared to low-grade disease (OR: 1.01, 95% CI: 0.97,1.04). There was some evidence that the genetic risk score was associated with higher odds of having nonlocalised compared to localised stage disease (OR: 1.03, 95% CI: 1.01, 1.06). Amongst men with prostate cancer, there was no clear association between the genetic risk score and all-cause mortality (HR: 1.00, 95% CI: 0.97,1.04) or prostate cancer-specific mortality (HR: 1.03, 95% CI: 0.98,1.08). These results, which should have less bias from confounding than observational estimates, are not consistent with a substantial effect of coffee consumption on reducing prostate cancer incidence or progression.
Published: 2017

25. Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study

Author: Duell, Eric J., Lujan-Barroso, Leila, Sala, Núria, Deitz McElyea, Samantha, Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Weiderpass, Elisabete, Busund, Lill-Tove, Moi, Line, Muller, David, Aune, Dagfinn, Naccarati, Alessio, Panico, Salavatore, Tagliabue, Giovanna, Tumino, Rosario, Palli, Domenico, Kaaks, Rudolf, Katzke, Verena A., Boeing, Heiner, Bueno-De-Mesquita, Hendrik Bastiaan, Peeters, Petra H., Trichopoulou, Antonia, Lagiou, Pagona, Kotanidou, Anastasia, Travis, Ruth C., Wareham, Nick, Khaw, Kay-Tee, Quirõs, Jose Ramõn, Rodríguez-Barranco, Miguel, Dorronsoro, Miren, Chirlaque, María Dolores, Ardanaz, Eva, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Brennan, Paul, Gunter, Marc, Scelo, Ghislaine, Cote, Greg, Sherman, Stuart, and Korc, Murray
Subjects: VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762, cohort studies, VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762, pancreatic cancer, biomarkers, microRNAs
Abstract: Accepted manuscript version. Published version available in International Journal of Cancer 2017, 141 (5):905–915 . Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subsequent PDAC risk. A panel of eight miRs (miR-10a, -10b, -21-3p, -21-5p, -30c, -106b, -155 and -212) based on previous evidence from our group was evaluated in 225 microscopically confirmed PDAC cases and 225 controls matched on center, sex, fasting status and age/date/time of blood collection. MiR levels in prediagnostic plasma samples were determined by quantitative RT-PCR. Logistic regression was used to model levels and PDAC risk, adjusting for covariates and to estimate area under the receiver operating characteristic curves (AUC). Plasma miR-10b, -21-5p, -30c and -106b levels were significantly higher in cases diagnosed within 2 years of blood collection compared to matched controls (all p-values
Published: 2017

26. Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels

Author: Bonilla, Carolina, Lewis, Sarah J, Rowlands, Mari-Anne, Gaunt, Tom R, Davey Smith, George, Gunnell, David, Palmer, Tom, Donovan, Jenny L, Hamdy, Freddie C, Neal, David E, Eeles, Rosalind, Easton, Doug, Kote-Jarai, Zsofia, Al Olama, Ali Amin, Benlloch, Sara, Muir, Kenneth, Giles, Graham G, Wiklund, Fredrik, Grönberg, Henrik, Haiman, Christopher A, Schleutker, Johanna, Nordestgaard, Børge G, Travis, Ruth C, Pashayan, Nora, Khaw, Kay-Tee, Stanford, Janet L, Blot, William J, Thibodeau, Stephen, Maier, Christiane, Kibel, Adam S, Cybulski, Cezary, Cannon-Albright, Lisa, Brenner, Hermann, Park, Jong, Kaneva, Radka, Batra, Jyotsna, Teixeira, Manuel R, Pandha, Hardev, PRACTICAL consortium, Lathrop, Mark, Martin, Richard M, Holly, Jeff MP, Easton, Douglas [0000-0003-2444-3247], Khaw, Kay-Tee [0000-0002-8802-2903], and Apollo - University of Cambridge Repository
Subjects: Male, Prostatic Neoplasms, ALSPAC, Mendelian Randomization Analysis, Middle Aged, prostate cancer, insulin-like growth factor-binding proteins, Polymorphism, Single Nucleotide, PRACTICAL, United Kingdom, UKHLS, Insulin-Like Growth Factor Binding Proteins, single nucleotide polymorphisms, IGFBP3, Somatomedins, insulin-like growth factors, Case-Control Studies, Mendelian randomization, Humans, ProtecT, Longitudinal Studies, Neoplasm Grading, Aged, Genome-Wide Association Study, Neoplasm Staging
Abstract: Circulating insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are associated with prostate cancer. Using genetic variants as instruments for IGF peptides, we investigated whether these associations are likely to be causal. We identified from the literature 56 single nucleotide polymorphisms (SNPs) in the IGF axis previously associated with biomarker levels (8 from a genome-wide association study [GWAS] and 48 in reported candidate genes). In ∼700 men without prostate cancer and two replication cohorts (N ∼ 900 and ∼9,000), we examined the properties of these SNPS as instrumental variables (IVs) for IGF-I, IGF-II, IGFBP-2 and IGFBP-3. Those confirmed as strong IVs were tested for association with prostate cancer risk, low (< 7) vs. high (≥ 7) Gleason grade, localised vs. advanced stage, and mortality, in 22,936 controls and 22,992 cases. IV analysis was used in an attempt to estimate the causal effect of circulating IGF peptides on prostate cancer. Published SNPs in the IGFBP1/IGFBP3 gene region, particularly rs11977526, were strong instruments for IGF-II and IGFBP-3, less so for IGF-I. Rs11977526 was associated with high (vs. low) Gleason grade (OR per IGF-II/IGFBP-3 level-raising allele 1.05; 95% CI: 1.00, 1.10). Using rs11977526 as an IV we estimated the causal effect of a one SD increase in IGF-II (∼265 ng/mL) on risk of high vs. low grade disease as 1.14 (95% CI: 1.00, 1.31). Because of the potential for pleiotropy of the genetic instruments, these findings can only causally implicate the IGF pathway in general, not any one specific biomarker.
Published: 2016

27. Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort

Author: Duarte Salles, Talita, Fedirko, Veronika, Stepien, Magdalena, Aleksandrova, Krasimira, Bamia, Christina, Lagiou, Pagona, Laursen, Anne Sofie Dam, Hansen, Louise, Overvad, Kim, Tjønneland, Anne, Boutron Ruault, Marie Christine, Fagherazzi, Guy, His, Mathilde, Boeing, Heiner, Katzke, Verena, Kühn, Tilman, Trichopoulou, Antonia, Valanou, Elissavet, Kritikou, Maria, Masala, Giovanna, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Bueno de Mesquita, H. B. As, Peeters, Petra H, Hjartåker, Anette, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Bonet, Catalina, Chirlaque, Maria Dolores, Dorronsoro, Miren, Quirós, J. Ramón, Johansson, Ingegerd, Ohlsson, Bodil, Sjöberg, Klas, Wennberg, Maria, Khaw, Kay Tee, Travis, Ruth C, Wareham, Nick, Ferrari, Pietro, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J, Gunter, Marc, Lu, Yunxia, Jenab, Mazda, PANICO, SALVATORE, Duarte Salles, Talita, Fedirko, Veronika, Stepien, Magdalena, Aleksandrova, Krasimira, Bamia, Christina, Lagiou, Pagona, Laursen, Anne Sofie Dam, Hansen, Louise, Overvad, Kim, Tjønneland, Anne, Boutron Ruault, Marie Christine, Fagherazzi, Guy, His, Mathilde, Boeing, Heiner, Katzke, Verena, Kühn, Tilman, Trichopoulou, Antonia, Valanou, Elissavet, Kritikou, Maria, Masala, Giovanna, Panico, Salvatore, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Bueno de Mesquita, H. B. A, Peeters, Petra H, Hjartåker, Anette, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Bonet, Catalina, Chirlaque, Maria Dolore, Dorronsoro, Miren, Quirós, J. Ramón, Johansson, Ingegerd, Ohlsson, Bodil, Sjöberg, Kla, Wennberg, Maria, Khaw, Kay Tee, Travis, Ruth C, Wareham, Nick, Ferrari, Pietro, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J, Gunter, Marc, Lu, Yunxia, and Jenab, Mazda
Subjects: Male, Cancer Research, European populations, Risk Factors, Surveys and Questionnaires, Surveys and Questionnaire, Prospective Studies, INDEX, Incidence, Liver Neoplasms, hepatocellular carcinoma, Middle Aged, CANCER, NUTRITIONAL EPIDEMIOLOGY, MEDITERRANEAN DIET, Europe, Nutritional Statu, Oncology, Liver Neoplasm, dietary fat, Female, Case-Control Studie, Life Sciences & Biomedicine, Human, Adult, Risk, Carcinoma, Hepatocellular, cohort study, dietary fats, Aged, Case-Control Studies, Diet, Dietary Fats, Feeding Behavior, Humans, Life Style, Nutritional Status, Young Adult, FISH, INFLAMMATION, LIVER-DISEASE, Oncology & Carcinogenesis, METAANALYSIS, Science & Technology, Risk Factor, Carcinoma, Hepatocellular, ACIDS, digestive system diseases, Prospective Studie, Food Habit, RISK-FACTORS, European population, Food Habits, 1112 Oncology And Carcinogenesis
Abstract: The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC = 122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68-1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk. What's new? The rise of hepatocellular carcinoma (HCC) incidence in high- and middle-income countries, where relatively high-fat diets are common, suggests a possible etiological role for dietary fat. In the present study, potential associations between HCC and total fat intake, intake of fat subtypes and intake of fat from different sources were explored with data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Total fat intake, where monounsaturated fats predominated, was inversely associated with HCC risk. By contrast, no risk associations were detected for polyunsaturated or saturated fat intake or fat source.
Published: 2015

28. Circulating isoflavone and lignan concentrations and prostate cancer risk: a meta-analysis of individual participant data from seven prospective studies including 2,828 cases and 5,593 controls

Author: Perez-Cornago, Aurora, primary, Appleby, Paul N., additional, Boeing, Heiner, additional, Gil, Leire, additional, Kyrø, Cecilie, additional, Ricceri, Fulvio, additional, Murphy, Neil, additional, Trichopoulou, Antonia, additional, Tsilidis, Konstantinos K., additional, Khaw, Kay-Tee, additional, Luben, Robert N., additional, Gislefoss, Randi E, additional, Langseth, Hilde, additional, Drake, Isabel, additional, Sonestedt, Emily, additional, Wallström, Peter, additional, Stattin, Pär, additional, Johansson, Anders, additional, Landberg, Rikard, additional, Nilsson, Lena Maria, additional, Ozasa, Kotaro, additional, Tamakoshi, Akiko, additional, Mikami, Kazuya, additional, Kubo, Tatsuhiko, additional, Sawada, Norie, additional, Tsugane, Shoichiro, additional, Key, Timothy J., additional, Allen, Naomi E., additional, and Travis, Ruth C., additional
Published: 2018
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29. Pre‐diagnostic circulating insulin‐like growth factor‐I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition

Author: Lin, Crystal, primary, Travis, Ruth C., additional, Appleby, Paul N., additional, Tipper, Sarah, additional, Weiderpass, Elisabete, additional, Chang‐Claude, Jenny, additional, Gram, Inger T., additional, Kaaks, Rudolf, additional, Kiemeney, Lambertus A., additional, Ljungberg, Börje, additional, Tumino, Rosario, additional, Tjønneland, Anne, additional, Roswall, Nina, additional, Overvad, Kim, additional, Boutron‐Ruault, Marie‐Christine, additional, Manciniveri, Francesca Romana, additional, Severi, Gianluca, additional, Trichopoulou, Antonia, additional, Masala, Giovanna, additional, Sacerdote, Carlotta, additional, Agnoli, Claudia, additional, Panico, Salvatore, additional, Bueno‐de‐Mesquita, Bas, additional, Peeters, Petra H., additional, Salamanca‐Fernández, Elena, additional, Chirlaque, Maria‐Dolores, additional, Ardanaz, Eva, additional, Dorronsoro, Miren, additional, Menéndez, Virginia, additional, Luján‐Barroso, Leila, additional, Liedberg, Fredrik, additional, Freisling, Heinz, additional, Gunter, Marc, additional, Aune, Dagfinn, additional, Cross, Amanda J., additional, Riboli, Elio, additional, Key, Timothy J., additional, and Perez‐Cornago, Aurora, additional
Published: 2018
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30. Tumor-associated autoantibodies as early detection markers for ovarian cancer? A prospective evaluation

Author: Kaaks, Rudolf, primary, Fortner, Renée Turzanski, additional, Hüsing, Anika, additional, Barrdahl, Myrto, additional, Hopper, Marika, additional, Johnson, Theron, additional, Tjønneland, Anne, additional, Hansen, Louise, additional, Overvad, Kim, additional, Fournier, Agnès, additional, Boutron-Ruault, Marie-Christine, additional, Kvaskoff, Marina, additional, Dossus, Laure, additional, Johansson, Mattias, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Benetou, Vassiliki, additional, La Vecchia, Carlo, additional, Sieri, Sabina, additional, Mattiello, Amalia, additional, Palli, Domenico, additional, Tumino, Rosario, additional, Matullo, Giuseppe, additional, Onland-Moret, N. Charlotte, additional, Gram, Inger T., additional, Weiderpass, Elisabete, additional, Sánchez, Maria-Jose, additional, Navarro Sanchez, Carmen, additional, Duell, Eric J., additional, Ardanaz, Eva, additional, Larranaga, Nerea, additional, Lundin, Eva, additional, Idahl, Annika, additional, Jirström, Karin, additional, Nodin, Björn, additional, Travis, Ruth C., additional, Riboli, Elio, additional, Merritt, Melissa, additional, Aune, Dagfinn, additional, Terry, Kathryn, additional, Cramer, Daniel W., additional, and Anderson, Karen S., additional
Published: 2018
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31. Ovarian cancer early detection by circulating CA125 in the context of anti-CA125 autoantibody levels: Results from the EPIC cohort

Author: Fortner, Renée T., primary, Schock, Helena, additional, Le Cornet, Charlotte, additional, Hüsing, Anika, additional, Vitonis, Allison F., additional, Johnson, Theron S., additional, Fichorova, Raina N., additional, Fashemi, Titilayo, additional, Yamamoto, Hidemi S., additional, Tjønneland, Anne, additional, Hansen, Louise, additional, Overvad, Kim, additional, Boutron-Ruault, Marie-Christine, additional, Kvaskoff, Marina, additional, Severi, Gianluca, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Papatesta, Eleni-Maria, additional, La Vecchia, Carlo, additional, Palli, Domenico, additional, Sieri, Sabina, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Mattiello, Amalia, additional, Onland-Moret, N. Charlotte, additional, Peeters, Petra H., additional, Bueno-de-Mesquita, H. Bas, additional, Weiderpass, Elisabete, additional, Quirós, J. Ramón, additional, Duell, Eric J., additional, Sánchez, Maria-Jose, additional, Navarro, Carmen, additional, Ardanaz, Eva, additional, Larrañaga, Nerea, additional, Nodin, Björn, additional, Jirström, Karin, additional, Idahl, Annika, additional, Lundin, Eva, additional, Khaw, Kay-Tee, additional, Travis, Ruth C., additional, Gunter, Marc, additional, Johansson, Mattias, additional, Dossus, Laure, additional, Merritt, Melissa A., additional, Riboli, Elio, additional, Terry, Kathryn L., additional, Cramer, Daniel W., additional, and Kaaks, Rudolf, additional
Published: 2017
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32. Anti-Müllerian hormone and risk of ovarian cancer in nine cohorts

Author: Jung, Seungyoun, primary, Allen, Naomi, additional, Arslan, Alan A., additional, Baglietto, Laura, additional, Barricarte, Aurelio, additional, Brinton, Louise A., additional, Egleston, Brian L., additional, Falk, Roni T., additional, Fortner, Renée T., additional, Helzlsouer, Kathy J., additional, Gao, Yutang, additional, Idahl, Annika, additional, Kaaks, Rudolph, additional, Krogh, Vittorio, additional, Merritt, Melissa A., additional, Lundin, Eva, additional, Onland-Moret, N. Charlotte, additional, Rinaldi, Sabina, additional, Schock, Helena, additional, Shu, Xiao-Ou, additional, Sluss, Patrick M., additional, Staats, Paul N., additional, Sacerdote, Carlotta, additional, Travis, Ruth C., additional, Tjønneland, Anne, additional, Trichopoulou, Antonia, additional, Tworoger, Shelley S., additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, Zeleniuch-Jacquotte, Anne, additional, and Dorgan, Joanne F., additional
Published: 2017
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33. Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study

Author: Brunner, Clair, Davies, Neil M, Martin, Richard M, Eeles, Rosalind, Easton, Doug, Kote-Jarai, Zsofia, Al Olama, Ali Amin, Benlloch, Sara, Muir, Kenneth, Giles, Graham, Wiklund, Fredrik, Gronberg, Henrik, Haiman, Christopher A, Schleutker, Johanna, Nordestgaard, Børge G, Travis, Ruth C, Neal, David, Donovan, Jenny, Hamdy, Freddie C, Pashayan, Nora, Khaw, Kay-Tee, Stanford, Janet L, Blot, William J, Thibodeau, Stephen, Maier, Christiane, Kibel, Adam S, Cybulski, Cezary, Cannon-Albright, Lisa, Brenner, Hermann, Park, Jong, Kaneva, Radka, Batra, Jyotsna, Teixeira, Manuel R, Pandha, Hardev, PRACTICAL Consortium, Zuccolo, Luisa, Easton, Douglas [0000-0003-2444-3247], Khaw, Kay-Tee [0000-0002-8802-2903], and Apollo - University of Cambridge Repository
Subjects: Aged, 80 and over, Male, Alcohol Drinking, alcohol, Aldehyde Dehydrogenase, Mitochondrial, Incidence, Prostatic Neoplasms, Retinal Dehydrogenase, Aldehyde Dehydrogenase, Middle Aged, prostate cancer, Polymorphism, Single Nucleotide, Survival Analysis, Aldehyde Dehydrogenase 1 Family, Linkage Disequilibrium, Case-Control Studies, Disease Progression, Humans, Regression Analysis, alcohol metabolising genes, Neoplasm Grading, Mendelian randomisation, Aged
Abstract: Prostate cancer is the most common cancer in men in developed countries, and is a target for risk reduction strategies. The effects of alcohol consumption on prostate cancer incidence and survival remain unclear, potentially due to methodological limitations of observational studies. In this study, we investigated the associations of genetic variants in alcohol-metabolising genes with prostate cancer incidence and survival. We analysed data from 23,868 men with prostate cancer and 23,051 controls from 25 studies within the international PRACTICAL Consortium. Study-specific associations of 68 single nucleotide polymorphisms (SNPs) in 8 alcohol-metabolising genes (Alcohol Dehydrogenases (ADHs) and Aldehyde Dehydrogenases (ALDHs)) with prostate cancer diagnosis and prostate cancer-specific mortality, by grade, were assessed using logistic and Cox regression models, respectively. The data across the 25 studies were meta-analysed using fixed-effect and random-effects models. We found little evidence that variants in alcohol metabolising genes were associated with prostate cancer diagnosis. Four variants in two genes exceeded the multiple testing threshold for associations with prostate cancer mortality in fixed-effect meta-analyses. SNPs within ALDH1A2 associated with prostate cancer mortality were rs1441817 (fixed effects hazard ratio, HRfixed = 0.78; 95% confidence interval (95%CI):0.66,0.91; p values = 0.002); rs12910509, HRfixed = 0.76; 95%CI:0.64,0.91; p values = 0.003); and rs8041922 (HRfixed = 0.76; 95%CI:0.64,0.91; p values = 0.002). These SNPs were in linkage disequilibrium with each other. In ALDH1B1, rs10973794 (HRfixed = 1.43; 95%CI:1.14,1.79; p values = 0.002) was associated with prostate cancer mortality in men with low-grade prostate cancer. These results suggest that alcohol consumption is unlikely to affect prostate cancer incidence, but it may influence disease progression.
Published: 2016
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34. Blood lipids and prostate cancer: a Mendelian randomization analysis

Author: Bull, Caroline J, Bonilla, Carolina, Holly, Jeff MP, Perks, Claire M, Davies, Neil, Haycock, Philip, Yu, Oriana Hoi Yun, Richards, J Brent, Eeles, Rosalind, Easton, Doug, Kote-Jarai, Zsofia, Amin Al Olama, Ali, Benlloch, Sara, Muir, Kenneth, Giles, Graham G, MacInnis, Robert J, Wiklund, Fredrik, Gronberg, Henrik, Haiman, Christopher A, Schleutker, Johanna, Nordestgaard, Børge G, Travis, Ruth C, Neal, David, Pashayan, Nora, Khaw, Kay-Tee, Stanford, Janet L, Blot, William J, Thibodeau, Stephen, Maier, Christiane, Kibel, Adam S, Cybulski, Cezary, Cannon-Albright, Lisa, Brenner, Hermann, Park, Jong, Kaneva, Radka, Batra, Jyotsna, Teixeira, Manuel R, Micheal, Agnieszka, Pandha, Hardev, Smith, George Davey, Lewis, Sarah J, Martin, Richard M, PRACTICAL Consortium, Easton, Douglas [0000-0003-2444-3247], Amin Al Olama, Ali [0000-0002-7178-3431], Khaw, Kay-Tee [0000-0002-8802-2903], and Apollo - University of Cambridge Repository
Subjects: Male, Genetic Variation, Prostatic Neoplasms, Mendelian Randomization Analysis, prostate cancer, Lipids, Polymorphism, Single Nucleotide, statins, Cholesterol, Quantitative Trait, Heritable, Meta-Analysis as Topic, Case-Control Studies, Population Surveillance, Mendelian randomization, Odds Ratio, Humans, lipids (amino acids, peptides, and proteins), Genetic Predisposition to Disease, Neoplasm Grading, Genetic Association Studies, Genome-Wide Association Study, Neoplasm Staging
Abstract: Genetic risk scores were used as unconfounded instruments for specific lipid traits (Mendelian randomization) to assess whether circulating lipids causally influence prostate cancer risk. Data from 22,249 prostate cancer cases and 22,133 controls from 22 studies within the international PRACTICAL consortium were analyzed. Allele scores based on single nucleotide polymorphisms (SNPs) previously reported to be uniquely associated with each of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride (TG) levels, were first validated in an independent dataset, and then entered into logistic regression models to estimate the presence (and direction) of any causal effect of each lipid trait on prostate cancer risk. There was weak evidence for an association between the LDL genetic score and cancer grade: the odds ratio (OR) per genetically instrumented standard deviation (SD) in LDL, comparing high- (≥7 Gleason score) versus low-grade (
Published: 2016
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35. Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort

Author: Molina-Montes, Esther, Sánchez, María José, Zamora-Ros, Raul, Bueno-de-Mesquita, H. Bas, Wark, Petra A., Obon-Santacana, Mireia, Kühn, Tilman, Katzke, Verena, Travis, Ruth C., Ye, Weimin, Sund, Malin, Naccarati, Alessio, Mattiello, Amalia, Krogh, Vittorio, Martorana, Caterina, Masala, Giovanna, Amiano, Pilar, Huerta, José María, Barricarte, Aurelio, Quirós, José Ramón, Weiderpass, Elisabete, Angell Åsli, Lene, Skeie, Guri, Ericson, Ulrika, Sonestedt, Emily, Peeters, Petra H., Romieu, Isabelle, Scalbert, Augustin, Overvad, Kim, Clemens, Matthias, Boeing, Heiner, Trichopoulou, Antonia, Peppa, Eleni, Vidalis, Pavlos, Khaw, Kay Tee, Wareham, Nick, Olsen, Anja, Tjønneland, Anne, Boutroun-Rualt, Marie Christine, Clavel-Chapelon, Françoise, Cross, Amanda J., Lu, Yunxia, Riboli, Elio, Duell, Eric J., Khaw, Kay-Tee [0000-0002-8802-2903], Wareham, Nicholas [0000-0003-1422-2993], and Apollo - University of Cambridge Repository
Subjects: Male, Cancer Research, Oncology and Carcinogenesis, pancreatic cancer, Cohort Studies, Rare Diseases, Complementary and Integrative Health, Journal Article, Humans, Oncology & Carcinogenesis, Prospective Studies, Life Style, Nutrition, Cancer, Proportional Hazards Models, VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762, Prevention, lignans, food and beverages, cohort, Middle Aged, Diet Records, Europe, Pancreatic Neoplasms, Multicenter Study, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762, Oncology, flavonoids, Female, Digestive Diseases, diet, Cancer Epidemiology
Abstract: Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow‐up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center‐stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable‐adjusted HR for a doubling of intake = 1.03, 95% CI: 0.95–1.11 and 1.02; 95% CI: 0.89–1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake = 0.96, 95% CI: 0.91–1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort., What's new? Flavonoids and lignans found in plant‐based foods are potent cancer chemopreventive agents but little is known about their effects on pancreatic cancer risk. Here the authors address this question in a large prospective epidemiological study using comprehensively derived dietary data. Their results support growing evidence that there is no association between food‐based consumption of both substances with pancreatic cancer risk.
Published: 2016

36. Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study

Author: Duell, Eric J., primary, Lujan‐Barroso, Leila, additional, Sala, Núria, additional, Deitz McElyea, Samantha, additional, Overvad, Kim, additional, Tjonneland, Anne, additional, Olsen, Anja, additional, Weiderpass, Elisabete, additional, Busund, Lill‐Tove, additional, Moi, Line, additional, Muller, David, additional, Vineis, Paolo, additional, Aune, Dagfinn, additional, Matullo, Giuseppe, additional, Naccarati, Alessio, additional, Panico, Salvatore, additional, Tagliabue, Giovanna, additional, Tumino, Rosario, additional, Palli, Domenico, additional, Kaaks, Rudolf, additional, Katzke, Verena A., additional, Boeing, Heiner, additional, Bueno‐de‐Mesquita, H. B(as), additional, Peeters, Petra H., additional, Trichopoulou, Antonia, additional, Lagiou, Pagona, additional, Kotanidou, Anastasia, additional, Travis, Ruth C., additional, Wareham, Nick, additional, Khaw, Kay‐Tee, additional, Ramon Quiros, Jose, additional, Rodríguez‐Barranco, Miguel, additional, Dorronsoro, Miren, additional, Chirlaque, María‐Dolores, additional, Ardanaz, Eva, additional, Severi, Gianluca, additional, Boutron‐Ruault, Marie‐Christine, additional, Rebours, Vinciane, additional, Brennan, Paul, additional, Gunter, Marc, additional, Scelo, Ghislaine, additional, Cote, Greg, additional, Sherman, Stuart, additional, and Korc, Murray, additional
Published: 2017
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37. Fruit and vegetable intake and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Perez‐Cornago, Aurora, primary, Travis, Ruth C., additional, Appleby, Paul N., additional, Tsilidis, Konstantinos K., additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Overvad, Kim, additional, Katzke, Verena, additional, Kühn, Tilman, additional, Trichopoulou, Antonia, additional, Peppa, Eleni, additional, Kritikou, Maria, additional, Sieri, Sabina, additional, Palli, Domenico, additional, Sacerdote, Carlotta, additional, Tumino, Rosario, additional, Bueno‐de‐Mesquita, H. B(as), additional, Agudo, Antonio, additional, Larrañaga, Nerea, additional, Molina‐Portillo, Elena, additional, Ardanaz, Eva, additional, Chirlaque, Maria‐Dolores, additional, Lasheras, Cristina, additional, Stattin, Pär, additional, Wennberg, Maria, additional, Drake, Isabel, additional, Malm, Johan, additional, Schmidt, Julie A., additional, Khaw, Kay‐Tee, additional, Gunter, Marc, additional, Freisling, Heinz, additional, Huybrechts, Inge, additional, Aune, Dagfinn, additional, Cross, Amanda J, additional, Riboli, Elio, additional, and Key, Timothy J., additional
Published: 2017
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38. Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

Author: Perez-Cornago, Aurora, primary, Appleby, Paul N., additional, Tipper, Sarah, additional, Key, Timothy J., additional, Allen, Naomi E., additional, Nieters, Alexandra, additional, Vermeulen, Roel, additional, Roulland, Sandrine, additional, Casabonne, Delphine, additional, Kaaks, Rudolf, additional, Fortner, Renee T., additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, La Vecchia, Carlo, additional, Klinaki, Eleni, additional, Hansen, Louise, additional, Tjønneland, Anne, additional, Bonnet, Fabrice, additional, Fagherazzi, Guy, additional, Boutron-Ruault, Marie-Christine, additional, Pala, Valeria, additional, Masala, Giovanna, additional, Sacerdote, Carlotta, additional, Peeters, Petra H., additional, Bueno-de-Mesquita, H. Bas, additional, Weiderpass, Elisabete, additional, Dorronsoro, Miren, additional, Quirós, J. Ramón, additional, Barricarte, Aurelio, additional, Gavrila, Diana, additional, Agudo, Antonio, additional, Borgquist, Signe, additional, Rosendahl, Ann H., additional, Melin, Beatrice, additional, Wareham, Nick, additional, Khaw, Kay-Tee, additional, Gunter, Marc, additional, Riboli, Elio, additional, Vineis, Paolo, additional, and Travis, Ruth C., additional
Published: 2016
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39. Acrylamide and glycidamide hemoglobin adduct levels and endometrial cancer risk: A nested case-control study in nonsmoking postmenopausal women from the EPIC cohort

Author: Obón-Santacana, Mireia, Freisling, Heinz, Peeters, Petra H., Lujan-Barroso, Leila, Ferrari, Pietro, Boutron-Ruault, Marie Christine, Mesrine, Sylvie, Baglietto, Laura, Turzanski-Fortner, Renee, Katzke, Verena A., Boeing, Heiner, Quirós, J. Ramón, Molina-Portillo, Elena, Larrañaga, Nerea, Chirlaque, María Dolores, Barricarte, Aurelio, Khaw, Kay Tee, Wareham, Nick, Travis, Ruth C., Merritt, Melissa A., Gunter, Marc J., Trichopoulou, Antonia, Lagiou, Pagona, Naska, Androniki, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Fiano, Valentina, Galassom, Rocco, Bueno-de-Mesquita, H. B., Onland-Moret, N. Charlotte, Idahl, Annika, Lundin, Eva, Weiderpass, Elisabete, Vesper, Hubert, Riboli, Elio, Duell, Eric J., and University Medical Center Utrecht
Subjects: Risk, Cancer Research, Glycidamide, BIOMARKERS, BREAST, Article, acrylamide, endometrial cancer, EPIC, glycidamide, hemoglobin adduct, Acrylamide, Biomarkers, Case-Control Studies, Endometrial Neoplasms, Epoxy Compounds, Female, Hemoglobins, Humans, Middle Aged, Postmenopause, Prospective Studies, Medicine (all), Oncology, Endometrial cancer, FOOD, Journal Article, Hemoglobin adduct, EXPOSURE, Oncology & Carcinogenesis, ASSOCIATIONS, Science & Technology, Research Support, Non-U.S. Gov't, OVARIAN, DIETARY ACRYLAMIDE, MODEL, Life Sciences & Biomedicine, 1112 Oncology And Carcinogenesis
Abstract: Acrylamide, classified in 1994 by IARC as "probably carcinogenic to humans," was discovered in 2002 in some heat-treated, carbohydrate-rich foods. Four prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The purpose of this nested case-control study, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, was to evaluate, for the first time, the association between hemoglobin adducts of acrylamide (HbAA) and glycidamide (HbGA) and the risk of developing EC in non-smoking postmenopausal women. Hemoglobin adducts were measured in red blood cells by HPLC/MS/MS. Four exposure variables were evaluated: HbAA, HbGA, their sum (HbAA+HbGA), and their ratio (HbGA/HbAA). The association between hemoglobin adducts and EC was evaluated using unconditional multivariable logistic regression models, and included 383 EC cases (171 were type-I EC), and 385 controls. Exposure variables were analyzed in quintiles based on control distributions. None of the biomarker variables had an effect on overall EC (HRHbAA;Q5vsQ1 : 0.84, 95%CI: 0.49-1.48; HRHbGA;Q5vsQ1 : 0.94, 95%CI: 0.54-1.63) or type-I EC risk. Additionally, none of the subgroups investigated (BMI 25 vs. ≥25 kg m(-2) , alcohol drinkers vs. never drinkers, oral contraceptive users vs. non-users) demonstrated effect measure modification. Hemoglobin adducts of acrylamide or glycidamide were not associated with EC or type-I EC risk in 768 nonsmoking postmenopausal women from the EPIC cohort.
Published: 2015

40. Reproductive and hormone-related risk factors for epithelial ovarian cancer by histologic pathways, invasiveness and histologic subtypes: results from the EPIC cohort

Author: Fortner, Renée T, Ose, Jennifer, Merritt, Melissa A., Schock, Helena, Tjønneland, Anne, Hansen, Louise, Overvad, Kim, Dossus, Laure, Clavel Chapelon, Françoise, Baglietto, Laura, Boeing, Heiner, Trichopoulou, Antonia, Benetou, Vassiliki, Lagiou, Pagona, Agnoli, Claudia, Mattiello, Amalia, Masala, Giovanna, Tumino, Rosario, Sacerdote, Carlotta, Bueno De Mesquita, H. B., Onland Moret, N. Charlotte, Peeters, Petra H., Weiderpass, Elisabete, Torhild Gram, Inger, Duell, Eric J, Larrañaga, Nerea, Ardanaz, Eva, Sánchez, María José, Chirlaque, M. D., Brändstedt, Jenny, Idahl, Annika, Lundin, Eva, Khaw, Kay Tee, Wareham, Nick, Travis, Ruth C., Rinaldi, Sabina, Romieu, Isabelle, Gunter, Marc J., Riboli, Elio, and Kaaks, Rudolf
Subjects: Adult, Cancer Research, endocrine system diseases, Term Birth, Carcinoma, Ovarian Epithelial, Article, Contraceptives, Oral, Hormonal, histologic subtype, dualistic model, AGE, ovarian cancer, reproductive factors, Medicine (all), Oncology, Pregnancy, Risk Factors, Humans, Neoplasms, Glandular and Epithelial, Prospective Studies, Oncology & Carcinogenesis, Aged, Ovarian Neoplasms, Science & Technology, ENDOMETRIAL CANCER, Middle Aged, female genital diseases and pregnancy complications, Europe, OBESITY, NUTRITION, Female, Life Sciences & Biomedicine, 1112 Oncology And Carcinogenesis
Abstract: Whether risk factors for epithelial ovarian cancer (EOC) differ by subtype (i.e., dualistic pathway of carcinogenesis, histologic subtype) is not well understood; however, data to date suggest risk factor differences. We examined associations between reproductive and hormone-related risk factors for EOC by subtype in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Among 334,126 women with data on reproductive and hormone-related risk factors (follow-up: 1992-2010), 1,245 incident cases of EOC with known histology and invasiveness were identified. Data on tumor histology, grade, and invasiveness, were available from cancer registries and pathology record review. We observed significant heterogeneity by the dualistic model (i.e., type I [low grade serous or endometrioid, mucinous, clear cell, malignant Brenner] vs. type II [high grade serous or endometrioid]) for full-term pregnancy (phet=0.02). Full-term pregnancy was more strongly inversely associated with type I than type II tumors (ever vs. never: type I: relative risk (RR) 0.47 [95% confidence interval (CI): 0.33-0.69]; type II, RR: 0.81 [0.61-1.06]). We observed no significant differences in risk in analyses by major histologic subtypes of invasive EOC (serous, mucinous, endometrioid, clear cell). None of the investigated factors were associated with borderline tumors. Established protective factors, including duration of oral contraceptive use and full term pregnancy, were consistently inversely associated with risk across histologic subtypes (e.g., ever full-term pregnancy: serous, RR: 0.73 [0.58-0.92]; mucinous, RR: 0.53 [0.30-0.95]; endometrioid, RR: 0.65 [0.40-1.06]; clear cell, RR: 0.34 [0.18-0.64]; phet=0.16). These results suggest limited heterogeneity between reproductive and hormone-related risk factors and EOC subtypes. What's new? Reproductive and hormone-related risk factors for epithelial ovarian cancer (EOC) have been extensively investigated. However, EOC is increasingly recognized as a heterogeneous disease and risk factor differences across EOC subtypes, as defined by the recently proposed dualistic pathway of ovarian carcinogenesis and histological characteristics, are not well understood. Here, the authors present a detailed prospective investigation on reproductive and hormone-related risk factors for borderline tumors and epithelial ovarian cancer by main histological subtypes and, for the first time, by the types defined by the dualistic pathway. The results suggest limited heterogeneity between reproductive and hormone-related risk factors and EOC subtypes.
Published: 2015

41. Alteration of amino acid and biogenic amine metabolism in hepatobiliary cancers: Findings from a prospective cohort study

Author: Stepien, Magdalena, primary, Duarte-Salles, Talita, additional, Fedirko, Veronika, additional, Floegel, Anne, additional, Barupal, Dinesh Kumar, additional, Rinaldi, Sabina, additional, Achaintre, David, additional, Assi, Nada, additional, Tjønneland, Anne, additional, Overvad, Kim, additional, Bastide, Nadia, additional, Boutron-Ruault, Marie-Christine, additional, Severi, Gianluca, additional, Kühn, Tilman, additional, Kaaks, Rudolf, additional, Aleksandrova, Krasimira, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Bamia, Christina, additional, Lagiou, Pagona, additional, Saieva, Calogero, additional, Agnoli, Claudia, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Naccarati, Alessio, additional, Bueno-de-Mesquita, H. Bas., additional, Peeters, Petra H., additional, Weiderpass, Elisabete, additional, Quirós, J. Ramón, additional, Agudo, Antonio, additional, Sánchez, María-José, additional, Dorronsoro, Miren, additional, Gavrila, Diana, additional, Barricarte, Aurelio, additional, Ohlsson, Bodil, additional, Sjöberg, Klas, additional, Werner, Mårten, additional, Sund, Malin, additional, Wareham, Nick, additional, Khaw, Kay-Tee, additional, Travis, Ruth C., additional, Schmidt, Julie A., additional, Gunter, Marc, additional, Cross, Amanda, additional, Vineis, Paolo, additional, Romieu, Isabelle, additional, Scalbert, Augustin, additional, and Jenab, Mazda, additional
Published: 2015
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42. ABO blood group alleles and prostate cancer risk: Results from the breast and prostate cancer cohort consortium (BPC3)

Author: Markt, Sarah C., primary, Shui, Irene M., additional, Unger, Robert H., additional, Urun, Yuksel, additional, Berg, Christine D., additional, Black, Amanda, additional, Brennan, Paul, additional, Bueno‐de‐Mesquita, H. Bas, additional, Gapstur, Susan M., additional, Giovannucci, Edward, additional, Haiman, Christopher, additional, Henderson, Brian, additional, Hoover, Robert N., additional, Hunter, David J., additional, Key, Timothy J., additional, Khaw, Kay‐Tee, additional, Canzian, Federico, additional, Larranga, Nerea, additional, Le Marchand, Loic, additional, Ma, Jing, additional, Naccarati, Alessio, additional, Siddiq, Afshan, additional, Stampfer, Meir J., additional, Stattin, Par, additional, Stevens, Victoria L., additional, Stram, Daniel O., additional, Tjønneland, Anne, additional, Travis, Ruth C., additional, Trichopoulos, Dimitrios, additional, Ziegler, Regina G., additional, Lindstrom, Sara, additional, Kraft, Peter, additional, Mucci, Lorelei A., additional, Choueiri, Toni K., additional, and Wilson, Kathryn M., additional
Published: 2015
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43. Alcohol intake and breast cancer in the European prospective investigation into cancer and nutrition

Author: Romieu, Isabelle, primary, Scoccianti, Chiara, additional, Chajès, Véronique, additional, de Batlle, Jordi, additional, Biessy, Carine, additional, Dossus, Laure, additional, Baglietto, Laura, additional, Clavel-Chapelon, Françoise, additional, Overvad, Kim, additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Kaaks, Rudolf, additional, Lukanova, Annekatrin, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Lagiou, Pagona, additional, Trichopoulos, Dimitrios, additional, Palli, Domenico, additional, Sieri, Sabina, additional, Tumino, Rosario, additional, Vineis, Paolo, additional, Panico, Salvatore, additional, Bueno-de-Mesquita, H. Bas, additional, van Gils, Carla H., additional, Peeters, Petra H., additional, Lund, Eiliv, additional, Skeie, Guri, additional, Weiderpass, Elisabete, additional, Quirós García, José Ramón, additional, Chirlaque, María-Dolores, additional, Ardanaz, Eva, additional, Sánchez, María-José, additional, Duell, Eric J., additional, Amiano, Pilar, additional, Borgquist, Signe, additional, Wirfält, Elisabet, additional, Hallmans, Göran, additional, Johansson, Ingegerd, additional, Nilsson, Lena Maria, additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Key, Timothy J., additional, Travis, Ruth C., additional, Murphy, Neil, additional, Wark, Petra A., additional, Ferrari, Pietro, additional, and Riboli, Elio, additional
Published: 2015
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44. Prediction of individual genetic risk to prostate cancer using a polygenic score

Author: Szulkin, Robert, primary, Whitington, Thomas, additional, Eklund, Martin, additional, Aly, Markus, additional, Eeles, Rosalind A., additional, Easton, Douglas, additional, Kote-Jarai, ZSofia, additional, Amin Al Olama, Ali, additional, Benlloch, Sara, additional, Muir, Kenneth, additional, Giles, Graham G., additional, Southey, Melissa C., additional, Fitzgerald, Liesel M., additional, Henderson, Brian E., additional, Schumacher, Fredrick, additional, Haiman, Christopher A., additional, Schleutker, Johanna, additional, Wahlfors, Tiina, additional, Tammela, Teuvo LJ, additional, Nordestgaard, Børge G., additional, Key, Tim J., additional, Travis, Ruth C., additional, Neal, David E., additional, Donovan, Jenny L., additional, Hamdy, Freddie C., additional, Pharoah, Paul, additional, Pashayan, Nora, additional, Khaw, Kay-Tee, additional, Stanford, Janet L., additional, Thibodeau, Stephen N., additional, McDonnell, Shannon K., additional, Schaid, Daniel J., additional, Maier, Christiane, additional, Vogel, Walther, additional, Luedeke, Manuel, additional, Herkommer, Kathleen, additional, Kibel, Adam S., additional, Cybulski, Cezary, additional, Lubiński, Jan, additional, Kluźniak, Wojciech, additional, Cannon-Albright, Lisa, additional, Brenner, Hermann, additional, Butterbach, Katja, additional, Stegmaier, Christa, additional, Park, Jong Y., additional, Sellers, Thomas, additional, Lim, Hui-Yi, additional, Slavov, Chavdar, additional, Kaneva, Radka, additional, Mitev, Vanio, additional, Batra, Jyotsna, additional, Clements, Judith A., additional, BioResource, The Australian Prostate Cancer, additional, Spurdle, Amanda, additional, Teixeira, Manuel R., additional, Paulo, Paula, additional, Maia, Sofia, additional, Pandha, Hardev, additional, Michael, Agnieszka, additional, Kierzek, Andrzej, additional, consortium, the PRACTICAL, additional, Gronberg, Henrik, additional, and Wiklund, Fredrik, additional
Published: 2015
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45. Alcohol consumption and the risk of renal cancers in the European prospective investigation into cancer and nutrition (EPIC)

Author: Wozniak, Magdalena B., primary, Brennan, Paul, additional, Brenner, Darren R., additional, Overvad, Kim, additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Boutron-Ruault, Marie-Christine, additional, Clavel-Chapelon, Françoise, additional, Fagherazzi, Guy, additional, Katzke, Verena, additional, Kühn, Tilman, additional, Boeing, Heiner, additional, Bergmann, Manuela M., additional, Steffen, Annika, additional, Naska, Androniki, additional, Trichopoulou, Antonia, additional, Trichopoulos, Dimitrios, additional, Saieva, Calogero, additional, Grioni, Sara, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Vineis, Paolo, additional, Bueno-de-Mesquita, H. Bas, additional, Peeters, Petra H., additional, Hjartåker, Anette, additional, Weiderpass, Elisabete, additional, Arriola, Larraitz, additional, Molina-Montes, Esther, additional, Duell, Eric J., additional, Santiuste, Carmen, additional, Alonso de la Torre, Ramón, additional, Barricarte Gurrea, Aurelio, additional, Stocks, Tanja, additional, Johansson, Mattias, additional, Ljungberg, Börje, additional, Wareham, Nick, additional, Khaw, Kay-Tee, additional, Travis, Ruth C., additional, Cross, Amanda J., additional, Murphy, Neil, additional, Riboli, Elio, additional, and Scelo, Ghislaine, additional
Published: 2015
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46. Risk of second primary malignancies in women with breast cancer: Results from the European prospective investigation into cancer and nutrition (EPIC)

Author: Ricceri, Fulvio, primary, Fasanelli, Francesca, additional, Giraudo, Maria Teresa, additional, Sieri, Sabina, additional, Tumino, Rosario, additional, Mattiello, Amalia, additional, Vagliano, Liliana, additional, Masala, Giovanna, additional, Quirós, J. Ramón, additional, Travier, Noemie, additional, Sánchez, María-José, additional, Larranaga, Nerea, additional, Chirlaque, María-Dolores, additional, Ardanaz, Eva, additional, Tjonneland, Anne, additional, Olsen, Anja, additional, Overvad, Kim, additional, Chang-Claude, Jenny, additional, Kaaks, Rudolf, additional, Boeing, Heiner, additional, Clavel-Chapelon, Françoise, additional, Kvaskoff, Marina, additional, Dossus, Laure, additional, Trichopoulou, Antonia, additional, Benetou, Vassiliki, additional, Adarakis, George, additional, Bueno-de-Mesquita, H. Bas, additional, Peeters, Petra H., additional, Sund, Malin, additional, Andersson, Anne, additional, Borgquist, Signe, additional, Butt, Salma, additional, Weiderpass, Elisabete, additional, Skeie, Guri, additional, Khaw, Kay-Tee, additional, Travis, Ruth C., additional, Rinaldi, Sabina, additional, Romieu, Isabelle, additional, Gunter, Marc, additional, Kadi, Mai, additional, Riboli, Elio, additional, Vineis, Paolo, additional, and Sacerdote, Carlotta, additional
Published: 2015
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47. Plasma fetuin-A concentration, genetic variation in theAHSGgene and risk of colorectal cancer

Author: Nimptsch, Katharina, primary, Aleksandrova, Krasimira, additional, Boeing, Heiner, additional, Janke, Jürgen, additional, Lee, Young-Ae, additional, Jenab, Mazda, additional, Kong, So Yeon, additional, Tsilidis, Konstantinos K., additional, Weiderpass, Elisabete, additional, Bueno-De-Mesquita, H. Bas, additional, Siersema, Peter D., additional, Jansen, Eugène H.J.M., additional, Trichopoulou, Antonia, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Wu, Chunsen, additional, Overvad, Kim, additional, Boutron-Ruault, Marie-Christine, additional, Racine, Antoine, additional, Freisling, Heinz, additional, Katzke, Verena, additional, Kaaks, Rudolf, additional, Lagiou, Pagona, additional, Trichopoulos, Dimitrios, additional, Severi, Gianluca, additional, Naccarati, Alessio, additional, Mattiello, Amalia, additional, Palli, Domenico, additional, Grioni, Sara, additional, Tumino, Rosario, additional, Peeters, Petra H., additional, Ljuslinder, Ingrid, additional, Nyström, Hanna, additional, Brändstedt, Jenny, additional, Sánchez, María-José, additional, Gurrea, Aurelio Barricarte, additional, Bonet, Catalina Bonet, additional, Chirlaque, María-Dolores, additional, Dorronsoro, Miren, additional, Quirós, José Ramón, additional, Travis, Ruth C., additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Riboli, Elio, additional, Gunter, Marc J., additional, and Pischon, Tobias, additional
Published: 2015
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48. Healthy lifestyle and risk of breast cancer among postmenopausal women in the European Prospective Investigation into Cancer and Nutrition cohort study

Author: McKenzie, Fiona, primary, Ferrari, Pietro, additional, Freisling, Heinz, additional, Chajès, Veronique, additional, Rinaldi, Sabina, additional, de Batlle, Jordi, additional, Dahm, Christina C, additional, Overvad, Kim, additional, Baglietto, Laura, additional, Dartois, Laureen, additional, Dossus, Laure, additional, Lagiou, Pagona, additional, Trichopoulos, Dimitrios, additional, Trichopoulou, Antonia, additional, Krogh, Vittorio, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Rosso, Stefano, additional, Bueno-de-Mesquita, H. Bas, additional, May, Anne, additional, Peeters, Petra H, additional, Weiderpass, Elisabete, additional, Buckland, Genevieve, additional, Sanchez, Maria-Jose, additional, Navarro, Carmen, additional, Ardanaz, Eva, additional, Andersson, Anne, additional, Sund, Malin, additional, Ericson, Ulrika, additional, Wirfält, Elisabet, additional, Key, Tim J, additional, Travis, Ruth C, additional, Gunter, Marc, additional, Riboli, Elio, additional, Vergnaud, Anne-Claire, additional, and Romieu, Isabelle, additional
Published: 2014
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49. Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: Multicentre, prospective cohort study

Author: Bamia, Christina, primary, Lagiou, Pagona, additional, Jenab, Mazda, additional, Trichopoulou, Antonia, additional, Fedirko, Veronika, additional, Aleksandrova, Krasimira, additional, Pischon, Tobias, additional, Overvad, Kim, additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Boutron-Ruault, Marie-Christine, additional, Fagherazzi, Guy, additional, Racine, Antoine, additional, Kuhn, Tilman, additional, Boeing, Heiner, additional, Floegel, Anna, additional, Benetou, Vasiliki, additional, Palli, Domenico, additional, Grioni, Sara, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Vineis, Paolo, additional, Bueno-de-Mesquita, H.Bas, additional, Dik, Vincent K., additional, Bhoo-Pathy, Nirmala, additional, Uiterwaal, Cuno S. P. M., additional, Weiderpass, Elisabete, additional, Lund, Eiliv, additional, Quirós, J. Ramón, additional, Zamora-Ros, Raul, additional, Molina-Montes, Esther, additional, Chirlaque, Maria-Dolores, additional, Ardanaz, Eva, additional, Dorronsoro, Miren, additional, Lindkvist, Björn, additional, Wallström, Peter, additional, Nilsson, Lena Maria, additional, Sund, Malin, additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Bradbury, Kathryn E., additional, Travis, Ruth C., additional, Ferrari, Pietro, additional, Duarte-Salles, Talita, additional, Stepien, Magdalena, additional, Gunter, Marc, additional, Murphy, Neil, additional, Riboli, Elio, additional, and Trichopoulos, Dimitrios, additional
Published: 2014
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50. A prospective study of one-carbon metabolism biomarkers and cancer of the head and neck and esophagus

Author: Fanidi, Anouar, primary, Relton, Caroline, additional, Ueland, Per Magne, additional, Midttun, Øivind, additional, Vollset, Stein Emil, additional, Travis, Ruth C., additional, Trichopoulou, Antonia, additional, Lagiou, Pagona, additional, Trichopoulos, Dimitrios, additional, Bueno-de-Mesquita, H Bas, additional, Ros, Martine, additional, Boeing, Heiner, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Palli, Domenico, additional, Sieri, Sabina, additional, Vineis, Paolo, additional, Sánchez, María-José, additional, Huerta, José María, additional, Barricarte Gurrea, Aurelio, additional, Luján-Barroso, Leila, additional, Quirós, J Ramón, additional, Tjønneland, Anne, additional, Halkjaer, Jytte, additional, Boutron-Ruault, Marie-Christine, additional, Clavel-Chapelon, Françoise, additional, Cadeau, Claire, additional, Weiderpass, Elisabete, additional, Johansson, Mikael, additional, Riboli, Elio, additional, Brennan, Paul, additional, and Johansson, Mattias, additional
Published: 2014
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