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Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort
- Source :
- Duarte-Salles, T, Fedirko, V, Stepien, M, Aleksandrova, K, Bamia, C, Lagiou, P, Laursen, A S D, Hansen, L, Overvad, K, Tjønneland, A, Boutron-Ruault, M-C, Fagherazzi, G, His, M, Boeing, H, Katzke, V, Kühn, T, Trichopoulou, A, Valanou, E, Kritikou, M, Masala, G, Panico, S, Sieri, S, Ricceri, F, Tumino, R, Bueno-de-Mesquita, H B, Peeters, P H, Hjartåker, A, Skeie, G, Weiderpass, E, Ardanaz, E, Bonet, C, Chirlaque, M-D, Dorronsoro, M, Quirós, J R, Johansson, I, Ohlsson, B, Sjöberg, K, Wennberg, M, Khaw, K-T, Travis, R C, Wareham, N, Ferrari, P, Freisling, H, Romieu, I, Cross, A J, Gunter, M, Lu, Y & Jenab, M 2015, ' Dietary Fat, Fat Subtypes and Hepatocellular Carcinoma in a Large European Cohort ', International Journal of Cancer, vol. 137, no. 11, pp. 2715-28 . https://doi.org/10.1002/ijc.29643, International Journal of Cancer, 137(11), 2715. Wiley-Liss Inc., Duarte-Salles, T; Fedirko, V; Stepien, M; Aleksandrova, K; Bamia, C; Lagiou, P; et al.(2015). Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort.. International journal of cancer, 137(11), 2715-2728. doi: 10.1002/ijc.29643. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8fd1q079
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC = 122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68-1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk. What's new? The rise of hepatocellular carcinoma (HCC) incidence in high- and middle-income countries, where relatively high-fat diets are common, suggests a possible etiological role for dietary fat. In the present study, potential associations between HCC and total fat intake, intake of fat subtypes and intake of fat from different sources were explored with data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Total fat intake, where monounsaturated fats predominated, was inversely associated with HCC risk. By contrast, no risk associations were detected for polyunsaturated or saturated fat intake or fat source.
- Subjects :
- Male
Cancer Research
European populations
Risk Factors
Surveys and Questionnaires
Surveys and Questionnaire
Prospective Studies
INDEX
Incidence
Liver Neoplasms
hepatocellular carcinoma
Middle Aged
CANCER
NUTRITIONAL EPIDEMIOLOGY
MEDITERRANEAN DIET
Europe
Nutritional Statu
Oncology
Liver Neoplasm
dietary fat
Female
Case-Control Studie
Life Sciences & Biomedicine
Human
Adult
Risk
Carcinoma, Hepatocellular
cohort study
dietary fats
Aged
Case-Control Studies
Diet
Dietary Fats
Feeding Behavior
Humans
Life Style
Nutritional Status
Young Adult
FISH
INFLAMMATION
LIVER-DISEASE
Oncology & Carcinogenesis
METAANALYSIS
Science & Technology
Risk Factor
Carcinoma
Hepatocellular
ACIDS
digestive system diseases
Prospective Studie
Food Habit
RISK-FACTORS
European population
Food Habits
1112 Oncology And Carcinogenesis
Subjects
Details
- Language :
- English
- ISSN :
- 00207136
- Database :
- OpenAIRE
- Journal :
- Duarte-Salles, T, Fedirko, V, Stepien, M, Aleksandrova, K, Bamia, C, Lagiou, P, Laursen, A S D, Hansen, L, Overvad, K, Tjønneland, A, Boutron-Ruault, M-C, Fagherazzi, G, His, M, Boeing, H, Katzke, V, Kühn, T, Trichopoulou, A, Valanou, E, Kritikou, M, Masala, G, Panico, S, Sieri, S, Ricceri, F, Tumino, R, Bueno-de-Mesquita, H B, Peeters, P H, Hjartåker, A, Skeie, G, Weiderpass, E, Ardanaz, E, Bonet, C, Chirlaque, M-D, Dorronsoro, M, Quirós, J R, Johansson, I, Ohlsson, B, Sjöberg, K, Wennberg, M, Khaw, K-T, Travis, R C, Wareham, N, Ferrari, P, Freisling, H, Romieu, I, Cross, A J, Gunter, M, Lu, Y & Jenab, M 2015, ' Dietary Fat, Fat Subtypes and Hepatocellular Carcinoma in a Large European Cohort ', International Journal of Cancer, vol. 137, no. 11, pp. 2715-28 . https://doi.org/10.1002/ijc.29643, International Journal of Cancer, 137(11), 2715. Wiley-Liss Inc., Duarte-Salles, T; Fedirko, V; Stepien, M; Aleksandrova, K; Bamia, C; Lagiou, P; et al.(2015). Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort.. International journal of cancer, 137(11), 2715-2728. doi: 10.1002/ijc.29643. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8fd1q079
- Accession number :
- edsair.pmid.dedup....7d437695f2c1bcc4c1929c3dfc29e43a