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Blood lipids and prostate cancer: a Mendelian randomization analysis
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Genetic risk scores were used as unconfounded instruments for specific lipid traits (Mendelian randomization) to assess whether circulating lipids causally influence prostate cancer risk. Data from 22,249 prostate cancer cases and 22,133 controls from 22 studies within the international PRACTICAL consortium were analyzed. Allele scores based on single nucleotide polymorphisms (SNPs) previously reported to be uniquely associated with each of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride (TG) levels, were first validated in an independent dataset, and then entered into logistic regression models to estimate the presence (and direction) of any causal effect of each lipid trait on prostate cancer risk. There was weak evidence for an association between the LDL genetic score and cancer grade: the odds ratio (OR) per genetically instrumented standard deviation (SD) in LDL, comparing high- (≥7 Gleason score) versus low-grade (
- Subjects :
- Male
Genetic Variation
Prostatic Neoplasms
Mendelian Randomization Analysis
prostate cancer
Lipids
Polymorphism, Single Nucleotide
statins
Cholesterol
Quantitative Trait, Heritable
Meta-Analysis as Topic
Case-Control Studies
Population Surveillance
Mendelian randomization
Odds Ratio
Humans
lipids (amino acids, peptides, and proteins)
Genetic Predisposition to Disease
Neoplasm Grading
Genetic Association Studies
Genome-Wide Association Study
Neoplasm Staging
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....3ddb2488d3c6e6c29111dbd83033ddbf
- Full Text :
- https://doi.org/10.17863/cam.930